Ina Skyt

Painful stimulation and transient blocking of nerve transduction due to local anesthesia evoke perceptual distortions of the face in healthy volunteers

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Painful stimulation and transient blocking of nerve transduction due to local anesthesia evoke perceptual distortions of the face in healthy volunteers. / Skyt, Ina ; Dagsdóttir, Lilja; Vase, Lene; Baad-Hansen, Lene; Castrillon, Eduardo; Roepstorff, Andreas; Jensen, Troels Staehelin; Svensson, Peter.

In: Journal of Pain, Vol. 16, No. 4, 2015, p. 335-345.

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@article{c736e443c18349d9b65d6b4cdc7f39f0,
title = "Painful stimulation and transient blocking of nerve transduction due to local anesthesia evoke perceptual distortions of the face in healthy volunteers",
abstract = "Anecdotally, orofacial pain patients sometimes report that the painful face area feels 'swollen'. Because there are no clinical signs of swelling, such illusions may represent perceptual distortions. In this study, we examine whether nociceptive stimulation can lead to perceptual distortion of the face in a way similar to that of local anesthesia. Sixteen healthy participants received injections of 0.4 mL hypertonic saline to induce short-term nociceptive stimulation, 0.4 mL Mepivacain (local anesthetics) to transiently block nerve transduction and 0.4 mL isotonic saline as a control condition. Injections were performed in both the infraorbital and the mental nerve region. Perceptual distortions were conceptualized as perceived changes in magnitude of the injected areas and the lips, and it was measured using 1) a verbal subjective rating scale and 2) a warping procedure. Prior to the study, participants filled in several psychological questionnaires. This study shows that both nociceptive stimulation (p<0.05) and transient blocking of nerve transduction (p<0.05) can lead to perceptual distortion of the face. A test-retest experiment including nine new healthy subjects supported the results. Perceptual distortions were positively correlated with the psychological variable dissociation in several conditions (p<0.05). Perceptual distortions may therefore be influenced by somatosensory changes and psychological mechanisms.PERSPECTIVE: Knowledge of the factors that influence the perception of the face is important to understand the possible implications of perceptual distortions in orofacial pain disorders (and possibly other chronic pain states). Such information may ultimately open up for new treatment strategies for persistent orofacial pain.",
author = "Ina Skyt and Lilja Dagsd{\'o}ttir and Lene Vase and Lene Baad-Hansen and Eduardo Castrillon and Andreas Roepstorff and Jensen, {Troels Staehelin} and Peter Svensson",
note = "Copyright {\circledC} 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.",
year = "2015",
doi = "10.1016/j.jpain.2015.01.006",
language = "English",
volume = "16",
pages = "335--345",
journal = "Journal of Pain",
issn = "1526-5900",
publisher = "Churchill Livingstone",
number = "4",

}

RIS

TY - JOUR

T1 - Painful stimulation and transient blocking of nerve transduction due to local anesthesia evoke perceptual distortions of the face in healthy volunteers

AU - Skyt, Ina

AU - Dagsdóttir, Lilja

AU - Vase, Lene

AU - Baad-Hansen, Lene

AU - Castrillon, Eduardo

AU - Roepstorff, Andreas

AU - Jensen, Troels Staehelin

AU - Svensson, Peter

N1 - Copyright © 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Anecdotally, orofacial pain patients sometimes report that the painful face area feels 'swollen'. Because there are no clinical signs of swelling, such illusions may represent perceptual distortions. In this study, we examine whether nociceptive stimulation can lead to perceptual distortion of the face in a way similar to that of local anesthesia. Sixteen healthy participants received injections of 0.4 mL hypertonic saline to induce short-term nociceptive stimulation, 0.4 mL Mepivacain (local anesthetics) to transiently block nerve transduction and 0.4 mL isotonic saline as a control condition. Injections were performed in both the infraorbital and the mental nerve region. Perceptual distortions were conceptualized as perceived changes in magnitude of the injected areas and the lips, and it was measured using 1) a verbal subjective rating scale and 2) a warping procedure. Prior to the study, participants filled in several psychological questionnaires. This study shows that both nociceptive stimulation (p<0.05) and transient blocking of nerve transduction (p<0.05) can lead to perceptual distortion of the face. A test-retest experiment including nine new healthy subjects supported the results. Perceptual distortions were positively correlated with the psychological variable dissociation in several conditions (p<0.05). Perceptual distortions may therefore be influenced by somatosensory changes and psychological mechanisms.PERSPECTIVE: Knowledge of the factors that influence the perception of the face is important to understand the possible implications of perceptual distortions in orofacial pain disorders (and possibly other chronic pain states). Such information may ultimately open up for new treatment strategies for persistent orofacial pain.

AB - Anecdotally, orofacial pain patients sometimes report that the painful face area feels 'swollen'. Because there are no clinical signs of swelling, such illusions may represent perceptual distortions. In this study, we examine whether nociceptive stimulation can lead to perceptual distortion of the face in a way similar to that of local anesthesia. Sixteen healthy participants received injections of 0.4 mL hypertonic saline to induce short-term nociceptive stimulation, 0.4 mL Mepivacain (local anesthetics) to transiently block nerve transduction and 0.4 mL isotonic saline as a control condition. Injections were performed in both the infraorbital and the mental nerve region. Perceptual distortions were conceptualized as perceived changes in magnitude of the injected areas and the lips, and it was measured using 1) a verbal subjective rating scale and 2) a warping procedure. Prior to the study, participants filled in several psychological questionnaires. This study shows that both nociceptive stimulation (p<0.05) and transient blocking of nerve transduction (p<0.05) can lead to perceptual distortion of the face. A test-retest experiment including nine new healthy subjects supported the results. Perceptual distortions were positively correlated with the psychological variable dissociation in several conditions (p<0.05). Perceptual distortions may therefore be influenced by somatosensory changes and psychological mechanisms.PERSPECTIVE: Knowledge of the factors that influence the perception of the face is important to understand the possible implications of perceptual distortions in orofacial pain disorders (and possibly other chronic pain states). Such information may ultimately open up for new treatment strategies for persistent orofacial pain.

U2 - 10.1016/j.jpain.2015.01.006

DO - 10.1016/j.jpain.2015.01.006

M3 - Journal article

VL - 16

SP - 335

EP - 345

JO - Journal of Pain

JF - Journal of Pain

SN - 1526-5900

IS - 4

ER -