Research output per year
Research output per year
Personal profile
Research
I have previously work with cell-specific delivery of the CRIPSR/Cas system in lentivirus-derived particles. Currently, I'm leveraging my knowlegde of genome engineering in the exciting field of cell-based immunotherapy for cancer treatment.
Profile
I am a postdoc at the Department of Biomedicine in Martin Roelsgaard Jakobsen's research group. I hold a PhD in molecular medicine with a focus on genome editing and targeted delivery using lentiviral vectors.
Areas of expertise
- Genome engineering
- Immunology
- Cell therapy
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Collaborations and top research areas from the last five years
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Research output
- 7 Journal article
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Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles
Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G., Dec 2024, In: Molecular Therapy Nucleic Acids. 35, 4, 102318.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access4 Citations (Scopus) -
Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and in vivo gene modification
Haldrup, J., Andersen, S., Labial, A. R. L., Wolff, J. H., Frandsen, F. P., Skov, T. W., Rovsing, A. B., Nielsen, I., Jakobsen, T. S., Askou, A. L., Thomsen, M. K., Corydon, T. J., Thomsen, E. A. & Mikkelsen, J. G., Oct 2023, In: Nucleic Acids Research. 51, 18, p. 10059-10074 16 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access22 Citations (Scopus) -
Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells.
van der Sluis, R. M., García-Rodríguez, J. L., Nielsen, I. H., Gris-Oliver, A., Becker, J., Costa, B., Chaudhry, M. Z., Werner, M., Laustsen, A., Pedersen, J. G., Gammelgaard, K. R., Mogensen, T. H., Kalinke, U., Cicin-Sain, L., Bak, R. O., Kristensen, L. S. & Jakobsen, M. R., 25 Mar 2025, In: Cell Reports. 44, 3, 115413.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis
Thomsen, M. M., Skouboe, M. K., Møhlenberg, M., Zhao, J., de Keukeleere, K., Heinz, J. L., Werner, M., Hollensen, A. K., Lønskov, J., Nielsen, I., Carter-Timofte, M. E., Zhang, B., Mikkelsen, J. G., Fisker, N., Paludan, S. R., Assing, K. & Mogensen, T. H., 26 Jan 2024, In: Journal of Clinical Immunology. 44, 2, 56.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Resistance to vincristine in DLBCL by disruption of p53-induced cell cycle arrest and apoptosis mediated by KIF18B and USP28
Rovsing, A. B., Thomsen, E. A., Nielsen, I., Skov, T. W., Luo, Y., Dybkær, K. & Mikkelsen, J. G., Aug 2023, In: British Journal of Haematology. 202, 4, p. 825-839 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)7 Downloads (Pure)