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Ditlev Egeskov Brodersen

Professor

Ditlev E. Brodersen

Microbial survival mechanisms

We are interested in uncovering fundamental, molecular mechanisms underlying central survival mechanisms in both bacteria and archaea with the aim of understanding how microorganisms respond to nutritional stress, antibiotics, and other changes in their environment. Knowledge of these mechanisms can be used to develop new antimicrobial drugs. We use bioinformatics analysis of bacterial (meta) genomes, classical biochemistry as well as hybrid methods in structural biology (x-ray crystallography, electron microscopy, and small-angle x-ray scattering) and microbiology (physiology and growth) in our work.

Current projects:

  • Mechanism of activation and activity of bacterial RNase (VapBC, RelBE, HicAB) and kinase (HipBA) toxin-antitoxin systems.
  • Understanding how phosphonate compounds are utilised as sources of phosphorous via the carbon-phosphorus lyase pathway in E. coli.
  • Understanding the interplay between toxin-antitoxin systems and CRISPR-Cas immunity in bacteria and archaea.
  • Regulation of (p)ppGpp synthesis and the effects of the alarmone during stress in bacteria.

More about the research in the lab.

 

Teaching

  • Lecturer and course responsible teacher on the bachelor course "Biomolecular Structure and Function" (10 ECTS, 2017-)
  • Organiser of a PhD course in structural biology (Parma University, Italy, 2017-2019)
  • Lecturer and teacher on the Master's/PhD course "Structural biology" (10 ECTS, 2011-2017)
  • Development of modern, research-based teaching methods.
  • Development of educational IT, founder of the learning platform, curriculearn.dk
  • Use of modern technology in teaching.

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