Henrik Wiggers

Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Standard

Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism. / Tougaard, Rasmus Stilling; Søvsø Szocska Hansen, Esben; Laustsen, Christoffer; Nørlinger, Thomas; Mikkelsen, Emmeli; Lindhardt, Jakob; Schroeder, Marie; Nielsen, Per Mose; Bertelsen, Lotte Bonde; Bøtker, Hans Erik; Kim, Won Yong; Wiggers, Henrik; Stødkilde-Jørgensen, Hans.

2017. Abstract from ISMRM 2017 Annual Meeting & Exhibition, Honolulu, United State, Honolulu, United States.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Harvard

Tougaard, RS, Søvsø Szocska Hansen, E, Laustsen, C, Nørlinger, T, Mikkelsen, E, Lindhardt, J, Schroeder, M, Nielsen, PM, Bertelsen, LB, Bøtker, HE, Kim, WY, Wiggers, H & Stødkilde-Jørgensen, H 2017, 'Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism', ISMRM 2017 Annual Meeting & Exhibition, Honolulu, United State, Honolulu, United States, 22/04/2017 - 27/04/2017.

APA

CBE

Tougaard RS, Søvsø Szocska Hansen E, Laustsen C, Nørlinger T, Mikkelsen E, Lindhardt J, Schroeder M, Nielsen PM, Bertelsen LB, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H. 2017. Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism. Abstract from ISMRM 2017 Annual Meeting & Exhibition, Honolulu, United State, Honolulu, United States.

MLA

Tougaard, Rasmus Stilling et al. Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism. ISMRM 2017 Annual Meeting & Exhibition, Honolulu, United State, 22 Apr 2017, Honolulu, United States, Conference abstract for conference, 2017.

Vancouver

Author

Bibtex

@conference{2b32358f54294ba78530d16978cfb5ec,
title = "Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism",
abstract = "Standardized large animal models for cardiac hyperpolarized MR metabolic studies are becoming increasingly important as translation into human trials progresses. We employed a porcine (n=17) model of fasting/feeding to study these two states and to examine normal feeding as a standardized model for increasing hyperpolarized [1-13C]Pyruvate signal in the heart. All metabolic ratios were higher in fed animals with no additional variance. This indicates the role of pyruvate uptake to be more important in pigs than in rodents, underlining the need for large animals in metabolic research, and also suggests feeding to be a feasible, standardized model for increasing signal.",
author = "Tougaard, {Rasmus Stilling} and {S{\o}vs{\o} Szocska Hansen}, Esben and Christoffer Laustsen and Thomas N{\o}rlinger and Emmeli Mikkelsen and Jakob Lindhardt and Marie Schroeder and Nielsen, {Per Mose} and Bertelsen, {Lotte Bonde} and B{\o}tker, {Hans Erik} and Kim, {Won Yong} and Henrik Wiggers and Hans St{\o}dkilde-J{\o}rgensen",
year = "2017",
language = "Dansk",
note = "null ; Conference date: 22-04-2017 Through 27-04-2017",

}

RIS

TY - ABST

T1 - Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism

AU - Tougaard, Rasmus Stilling

AU - Søvsø Szocska Hansen, Esben

AU - Laustsen, Christoffer

AU - Nørlinger, Thomas

AU - Mikkelsen, Emmeli

AU - Lindhardt, Jakob

AU - Schroeder, Marie

AU - Nielsen, Per Mose

AU - Bertelsen, Lotte Bonde

AU - Bøtker, Hans Erik

AU - Kim, Won Yong

AU - Wiggers, Henrik

AU - Stødkilde-Jørgensen, Hans

PY - 2017

Y1 - 2017

N2 - Standardized large animal models for cardiac hyperpolarized MR metabolic studies are becoming increasingly important as translation into human trials progresses. We employed a porcine (n=17) model of fasting/feeding to study these two states and to examine normal feeding as a standardized model for increasing hyperpolarized [1-13C]Pyruvate signal in the heart. All metabolic ratios were higher in fed animals with no additional variance. This indicates the role of pyruvate uptake to be more important in pigs than in rodents, underlining the need for large animals in metabolic research, and also suggests feeding to be a feasible, standardized model for increasing signal.

AB - Standardized large animal models for cardiac hyperpolarized MR metabolic studies are becoming increasingly important as translation into human trials progresses. We employed a porcine (n=17) model of fasting/feeding to study these two states and to examine normal feeding as a standardized model for increasing hyperpolarized [1-13C]Pyruvate signal in the heart. All metabolic ratios were higher in fed animals with no additional variance. This indicates the role of pyruvate uptake to be more important in pigs than in rodents, underlining the need for large animals in metabolic research, and also suggests feeding to be a feasible, standardized model for increasing signal.

M3 - Konferenceabstrakt til konference

Y2 - 22 April 2017 through 27 April 2017

ER -