Henrik Wiggers

Automatic extraction of myocardial mass and volumes using parametric images from dynamic nongated PET

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Automatic extraction of myocardial mass and volumes using parametric images from dynamic nongated PET. / Harms, Hendrik Johannes; Hansson, Nils Henrik Stubkjær; Tolbod, Lars Poulsen; Kim, Won Yong; Jakobsen, Steen; Bouchelouche, Kirsten; Wiggers, Henrik; Frøkiaer, Jørgen; Sörensen, Jens.

In: Journal of Nuclear Medicine, Vol. 57, No. 9, 28.04.2016, p. 1382-87.

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@article{4e4af289fc7d46a898c98e3a56ac7aad,
title = "Automatic extraction of myocardial mass and volumes using parametric images from dynamic nongated PET",
abstract = "Dynamic cardiac positron emission tomography (PET) is used to quantify molecular processes in vivo. However, measurements of left-ventricular (LV) mass and volumes require electrocardiogram (ECG)-gated PET data. The aim of this study was to explore the feasibility of measuring LV geometry using non-gated dynamic cardiac PET.METHODS: Thirty-five patients with aortic-valve stenosis and 10 healthy controls (HC) underwent a 27-min (11)C-acetate PET/CT scan and cardiac magnetic resonance imaging (CMR). HC were scanned twice to assess repeatability. Parametric images of uptake rate K1 and the blood pool were generated from non-gated dynamic data. Using software-based structure recognition the LV wall was automatically segmented from K1 images to derive mLV and wall thickness (WT). End-systolic (ESV) and end-diastolic (EDV) volumes were calculated using blood pool images and used to obtain stroke volume (SV) and LV ejection fraction (LVEF). PET measurements were compared with CMR.RESULTS: High and linear correlations were found for LV mass (r=0.95), ESV (r=0.93) and EDV (r=0.90), and slightly lower for SV (r=0.74), LVEF (r=0.81) and WT(r=0.78). Bland Altman analyses showed significant differences for mLV and WT only and an overestimation for LVEF at lower values. Intra- and inter-observer correlations were >0.95 for all PET measurements. PET repeatability accuracy in HC was comparable to CMR.CONCLUSION: LV mass and volumes are accurately and automatically generated from dynamic (11)C-acetate PET without ECG-gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.",
author = "Harms, {Hendrik Johannes} and Hansson, {Nils Henrik Stubkj{\ae}r} and Tolbod, {Lars Poulsen} and Kim, {Won Yong} and Steen Jakobsen and Kirsten Bouchelouche and Henrik Wiggers and J{\o}rgen Fr{\o}kiaer and Jens S{\"o}rensen",
note = "Copyright {\circledC} 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",
year = "2016",
month = "4",
day = "28",
doi = "10.2967/jnumed.115.170613",
language = "English",
volume = "57",
pages = "1382--87",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "SOC NUCLEAR MEDICINE INC",
number = "9",

}

RIS

TY - JOUR

T1 - Automatic extraction of myocardial mass and volumes using parametric images from dynamic nongated PET

AU - Harms, Hendrik Johannes

AU - Hansson, Nils Henrik Stubkjær

AU - Tolbod, Lars Poulsen

AU - Kim, Won Yong

AU - Jakobsen, Steen

AU - Bouchelouche, Kirsten

AU - Wiggers, Henrik

AU - Frøkiaer, Jørgen

AU - Sörensen, Jens

N1 - Copyright © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

PY - 2016/4/28

Y1 - 2016/4/28

N2 - Dynamic cardiac positron emission tomography (PET) is used to quantify molecular processes in vivo. However, measurements of left-ventricular (LV) mass and volumes require electrocardiogram (ECG)-gated PET data. The aim of this study was to explore the feasibility of measuring LV geometry using non-gated dynamic cardiac PET.METHODS: Thirty-five patients with aortic-valve stenosis and 10 healthy controls (HC) underwent a 27-min (11)C-acetate PET/CT scan and cardiac magnetic resonance imaging (CMR). HC were scanned twice to assess repeatability. Parametric images of uptake rate K1 and the blood pool were generated from non-gated dynamic data. Using software-based structure recognition the LV wall was automatically segmented from K1 images to derive mLV and wall thickness (WT). End-systolic (ESV) and end-diastolic (EDV) volumes were calculated using blood pool images and used to obtain stroke volume (SV) and LV ejection fraction (LVEF). PET measurements were compared with CMR.RESULTS: High and linear correlations were found for LV mass (r=0.95), ESV (r=0.93) and EDV (r=0.90), and slightly lower for SV (r=0.74), LVEF (r=0.81) and WT(r=0.78). Bland Altman analyses showed significant differences for mLV and WT only and an overestimation for LVEF at lower values. Intra- and inter-observer correlations were >0.95 for all PET measurements. PET repeatability accuracy in HC was comparable to CMR.CONCLUSION: LV mass and volumes are accurately and automatically generated from dynamic (11)C-acetate PET without ECG-gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.

AB - Dynamic cardiac positron emission tomography (PET) is used to quantify molecular processes in vivo. However, measurements of left-ventricular (LV) mass and volumes require electrocardiogram (ECG)-gated PET data. The aim of this study was to explore the feasibility of measuring LV geometry using non-gated dynamic cardiac PET.METHODS: Thirty-five patients with aortic-valve stenosis and 10 healthy controls (HC) underwent a 27-min (11)C-acetate PET/CT scan and cardiac magnetic resonance imaging (CMR). HC were scanned twice to assess repeatability. Parametric images of uptake rate K1 and the blood pool were generated from non-gated dynamic data. Using software-based structure recognition the LV wall was automatically segmented from K1 images to derive mLV and wall thickness (WT). End-systolic (ESV) and end-diastolic (EDV) volumes were calculated using blood pool images and used to obtain stroke volume (SV) and LV ejection fraction (LVEF). PET measurements were compared with CMR.RESULTS: High and linear correlations were found for LV mass (r=0.95), ESV (r=0.93) and EDV (r=0.90), and slightly lower for SV (r=0.74), LVEF (r=0.81) and WT(r=0.78). Bland Altman analyses showed significant differences for mLV and WT only and an overestimation for LVEF at lower values. Intra- and inter-observer correlations were >0.95 for all PET measurements. PET repeatability accuracy in HC was comparable to CMR.CONCLUSION: LV mass and volumes are accurately and automatically generated from dynamic (11)C-acetate PET without ECG-gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.

U2 - 10.2967/jnumed.115.170613

DO - 10.2967/jnumed.115.170613

M3 - Journal article

VL - 57

SP - 1382

EP - 1387

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 9

ER -