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Henrik Wiggers

Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan

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Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan. / Harms, Hans; Stubkjær Hansson, Nils Henrik; Kero, Tanja; Baron, Thomasz; Tolbod, Lars Poulsen; Kim, Won Yong; Frøkiær, Jørgen; Flachskampf, F.A.; Wiggers, Henrik; Sørensen, Jens.

In: Journal of Nuclear Cardiology, 26.06.2018, p. 1-8.

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Harms, Hans ; Stubkjær Hansson, Nils Henrik ; Kero, Tanja ; Baron, Thomasz ; Tolbod, Lars Poulsen ; Kim, Won Yong ; Frøkiær, Jørgen ; Flachskampf, F.A. ; Wiggers, Henrik ; Sørensen, Jens. / Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan. In: Journal of Nuclear Cardiology. 2018 ; pp. 1-8.

Bibtex

@article{5c01dd9bb2a84b0093a9c7f2086040f6,
title = "Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan",
abstract = "Background: Myocardial external efficiency (MEE) is defined as the ratio of kinetic energy associated with cardiac work [forward cardiac output (FCO)*mean systemic pressure] and the chemical energy from oxygen consumed (MVO2) by the left ventricular mass (LVM). We developed a fully automated method for estimating MEE based on a single 11C-acetate PET scan without ECG-gating. Methods and Results: Ten healthy controls, 34 patients with aortic valve stenosis (AVS), and 20 patients with mitral valve regurgitation (MVR) were recruited in a dual-center study. MVO2 was calculated using washout of 11C -acetate activity. FCO and LVM were calculated automatically using dynamic PET and parametric image formation. FCO and LVM were also obtained using cardiac magnetic resonance (CMR) in all subjects. The correlation between MEEPET-CMR and MEEPET was high (r = 0.85, P < 0.001) without significant bias. MEEPET was 23.6 ± 4.2% for controls and was lowered in AVS (17.2 ± 4.3%, P < 0.001) and in MVR (18.0 ± 5.2%, P = 0.004). MEEPET was strongly associated with both NYHA class (P < 0.001) and the magnitude of valvular dysfunction (mean aortic gradient: P < 0.001, regurgitant fraction: P = 0.009). Conclusion: A single 11C-acetate PET yields accurate and automated MEE results on different scanners. MEE might provide an unbiased measurement of the phenotypic response to valvular disease. ",
author = "Hans Harms and {Stubkj{\ae}r Hansson}, {Nils Henrik} and Tanja Kero and Thomasz Baron and Tolbod, {Lars Poulsen} and Kim, {Won Yong} and J{\o}rgen Fr{\o}ki{\ae}r and F.A. Flachskampf and Henrik Wiggers and Jens S{\o}rensen",
year = "2018",
month = jun,
day = "26",
doi = "10.1007/s12350-018-1338-0",
language = "Dansk",
pages = "1--8",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York LLC",

}

RIS

TY - JOUR

T1 - Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan

AU - Harms, Hans

AU - Stubkjær Hansson, Nils Henrik

AU - Kero, Tanja

AU - Baron, Thomasz

AU - Tolbod, Lars Poulsen

AU - Kim, Won Yong

AU - Frøkiær, Jørgen

AU - Flachskampf, F.A.

AU - Wiggers, Henrik

AU - Sørensen, Jens

PY - 2018/6/26

Y1 - 2018/6/26

N2 - Background: Myocardial external efficiency (MEE) is defined as the ratio of kinetic energy associated with cardiac work [forward cardiac output (FCO)*mean systemic pressure] and the chemical energy from oxygen consumed (MVO2) by the left ventricular mass (LVM). We developed a fully automated method for estimating MEE based on a single 11C-acetate PET scan without ECG-gating. Methods and Results: Ten healthy controls, 34 patients with aortic valve stenosis (AVS), and 20 patients with mitral valve regurgitation (MVR) were recruited in a dual-center study. MVO2 was calculated using washout of 11C -acetate activity. FCO and LVM were calculated automatically using dynamic PET and parametric image formation. FCO and LVM were also obtained using cardiac magnetic resonance (CMR) in all subjects. The correlation between MEEPET-CMR and MEEPET was high (r = 0.85, P < 0.001) without significant bias. MEEPET was 23.6 ± 4.2% for controls and was lowered in AVS (17.2 ± 4.3%, P < 0.001) and in MVR (18.0 ± 5.2%, P = 0.004). MEEPET was strongly associated with both NYHA class (P < 0.001) and the magnitude of valvular dysfunction (mean aortic gradient: P < 0.001, regurgitant fraction: P = 0.009). Conclusion: A single 11C-acetate PET yields accurate and automated MEE results on different scanners. MEE might provide an unbiased measurement of the phenotypic response to valvular disease.

AB - Background: Myocardial external efficiency (MEE) is defined as the ratio of kinetic energy associated with cardiac work [forward cardiac output (FCO)*mean systemic pressure] and the chemical energy from oxygen consumed (MVO2) by the left ventricular mass (LVM). We developed a fully automated method for estimating MEE based on a single 11C-acetate PET scan without ECG-gating. Methods and Results: Ten healthy controls, 34 patients with aortic valve stenosis (AVS), and 20 patients with mitral valve regurgitation (MVR) were recruited in a dual-center study. MVO2 was calculated using washout of 11C -acetate activity. FCO and LVM were calculated automatically using dynamic PET and parametric image formation. FCO and LVM were also obtained using cardiac magnetic resonance (CMR) in all subjects. The correlation between MEEPET-CMR and MEEPET was high (r = 0.85, P < 0.001) without significant bias. MEEPET was 23.6 ± 4.2% for controls and was lowered in AVS (17.2 ± 4.3%, P < 0.001) and in MVR (18.0 ± 5.2%, P = 0.004). MEEPET was strongly associated with both NYHA class (P < 0.001) and the magnitude of valvular dysfunction (mean aortic gradient: P < 0.001, regurgitant fraction: P = 0.009). Conclusion: A single 11C-acetate PET yields accurate and automated MEE results on different scanners. MEE might provide an unbiased measurement of the phenotypic response to valvular disease.

U2 - 10.1007/s12350-018-1338-0

DO - 10.1007/s12350-018-1338-0

M3 - Tidsskriftartikel

C2 - 29946824

SP - 1

EP - 8

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -