Department of Biology

Aarhus University Seal / Aarhus Universitets segl

Henrik Balslev

Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Scopoletin from Lasianthus lucidus Blume (Rubiaceae) : A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa. / Napiroon, Tiwtawat; Bacher, Markus; Balslev, Henrik; Tawaitakham, Kwankamol; Santimaleeworagun, Wichai; Vajrodaya, Srunya.

In: Journal of Applied Pharmaceutical Science, Vol. 8, No. 9, 01.01.2018, p. 1-6.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Napiroon, T, Bacher, M, Balslev, H, Tawaitakham, K, Santimaleeworagun, W & Vajrodaya, S 2018, 'Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa', Journal of Applied Pharmaceutical Science, vol. 8, no. 9, pp. 1-6. https://doi.org/10.7324/JAPS.2018.8901

APA

Napiroon, T., Bacher, M., Balslev, H., Tawaitakham, K., Santimaleeworagun, W., & Vajrodaya, S. (2018). Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa. Journal of Applied Pharmaceutical Science, 8(9), 1-6. https://doi.org/10.7324/JAPS.2018.8901

CBE

Napiroon T, Bacher M, Balslev H, Tawaitakham K, Santimaleeworagun W, Vajrodaya S. 2018. Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa. Journal of Applied Pharmaceutical Science. 8(9):1-6. https://doi.org/10.7324/JAPS.2018.8901

MLA

Vancouver

Napiroon T, Bacher M, Balslev H, Tawaitakham K, Santimaleeworagun W, Vajrodaya S. Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa. Journal of Applied Pharmaceutical Science. 2018 Jan 1;8(9):1-6. https://doi.org/10.7324/JAPS.2018.8901

Author

Napiroon, Tiwtawat ; Bacher, Markus ; Balslev, Henrik ; Tawaitakham, Kwankamol ; Santimaleeworagun, Wichai ; Vajrodaya, Srunya. / Scopoletin from Lasianthus lucidus Blume (Rubiaceae) : A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa. In: Journal of Applied Pharmaceutical Science. 2018 ; Vol. 8, No. 9. pp. 1-6.

Bibtex

@article{ba336d3fce374e6dbda4ad9b447956ce,
title = "Scopoletin from Lasianthus lucidus Blume (Rubiaceae): A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa",
abstract = "A bioassay-guided study of stem bark lipophilic extracts led to the isolation of a bioactive compound from Lasianthus lucidus Blume species related to traditional medicine for treatment of wound infections, bleeding, and fevers. Scopoletin (7-hydroxy-6-methoxycoumarin) could be isolated from stem bark extract yielding 1.4 μmol/g by dry weight. The minimum inhibitory concentrations of extracts and scopoletin proved to be effective against both strains of Pseudomonas aeruginosa ATCC 27853 (AmpC β-lactamase producing strain) and P. aeruginosa DMSC 37166 (clinical strain). They revealed the highest antibacterial effect at 128 μg/ml and morphological changes on bacterial cells were demonstrated by Field Emission Scanning Electron Microscope. The lipophilic extracts and the purified scopoletin from L. lucidus have clear antibacterial activities, especially acting against P. aeruginosa strains. They produce cell lysis, inflated swelling cell walls and cell walls sinking into cells in the same way.",
keywords = "Ethnomedicines, Infectious diseases, Lasianthus, Scopoletin",
author = "Tiwtawat Napiroon and Markus Bacher and Henrik Balslev and Kwankamol Tawaitakham and Wichai Santimaleeworagun and Srunya Vajrodaya",
year = "2018",
month = jan,
day = "1",
doi = "10.7324/JAPS.2018.8901",
language = "English",
volume = "8",
pages = "1--6",
journal = "Journal of Applied Pharmaceutical Science",
issn = "2231-3354",
publisher = "MediPoeia",
number = "9",

}

RIS

TY - JOUR

T1 - Scopoletin from Lasianthus lucidus Blume (Rubiaceae)

T2 - A potential antimicrobial against multidrug-resistant Pseudomonas aeruginosa

AU - Napiroon, Tiwtawat

AU - Bacher, Markus

AU - Balslev, Henrik

AU - Tawaitakham, Kwankamol

AU - Santimaleeworagun, Wichai

AU - Vajrodaya, Srunya

PY - 2018/1/1

Y1 - 2018/1/1

N2 - A bioassay-guided study of stem bark lipophilic extracts led to the isolation of a bioactive compound from Lasianthus lucidus Blume species related to traditional medicine for treatment of wound infections, bleeding, and fevers. Scopoletin (7-hydroxy-6-methoxycoumarin) could be isolated from stem bark extract yielding 1.4 μmol/g by dry weight. The minimum inhibitory concentrations of extracts and scopoletin proved to be effective against both strains of Pseudomonas aeruginosa ATCC 27853 (AmpC β-lactamase producing strain) and P. aeruginosa DMSC 37166 (clinical strain). They revealed the highest antibacterial effect at 128 μg/ml and morphological changes on bacterial cells were demonstrated by Field Emission Scanning Electron Microscope. The lipophilic extracts and the purified scopoletin from L. lucidus have clear antibacterial activities, especially acting against P. aeruginosa strains. They produce cell lysis, inflated swelling cell walls and cell walls sinking into cells in the same way.

AB - A bioassay-guided study of stem bark lipophilic extracts led to the isolation of a bioactive compound from Lasianthus lucidus Blume species related to traditional medicine for treatment of wound infections, bleeding, and fevers. Scopoletin (7-hydroxy-6-methoxycoumarin) could be isolated from stem bark extract yielding 1.4 μmol/g by dry weight. The minimum inhibitory concentrations of extracts and scopoletin proved to be effective against both strains of Pseudomonas aeruginosa ATCC 27853 (AmpC β-lactamase producing strain) and P. aeruginosa DMSC 37166 (clinical strain). They revealed the highest antibacterial effect at 128 μg/ml and morphological changes on bacterial cells were demonstrated by Field Emission Scanning Electron Microscope. The lipophilic extracts and the purified scopoletin from L. lucidus have clear antibacterial activities, especially acting against P. aeruginosa strains. They produce cell lysis, inflated swelling cell walls and cell walls sinking into cells in the same way.

KW - Ethnomedicines

KW - Infectious diseases

KW - Lasianthus

KW - Scopoletin

UR - http://www.scopus.com/inward/record.url?scp=85062068737&partnerID=8YFLogxK

U2 - 10.7324/JAPS.2018.8901

DO - 10.7324/JAPS.2018.8901

M3 - Journal article

AN - SCOPUS:85062068737

VL - 8

SP - 1

EP - 6

JO - Journal of Applied Pharmaceutical Science

JF - Journal of Applied Pharmaceutical Science

SN - 2231-3354

IS - 9

ER -