Hans Jürgen Hoffmann

The role of innate immunity in occupational allergy: recent findings

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The role of innate immunity in occupational allergy: recent findings. / Sigsgaard, Torben; Hoffmann, Hans Jürgen; Thorne, Peter S.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 8, No. 2, 2008, p. 120-5.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sigsgaard, T, Hoffmann, HJ & Thorne, PS 2008, 'The role of innate immunity in occupational allergy: recent findings', Current Opinion in Allergy and Clinical Immunology, vol. 8, no. 2, pp. 120-5. https://doi.org/10.1097/ACI.0b013e3282f82492

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Author

Sigsgaard, Torben ; Hoffmann, Hans Jürgen ; Thorne, Peter S. / The role of innate immunity in occupational allergy: recent findings. In: Current Opinion in Allergy and Clinical Immunology. 2008 ; Vol. 8, No. 2. pp. 120-5.

Bibtex

@article{95887bd0eb2511dd8f9a000ea68e967b,
title = "The role of innate immunity in occupational allergy: recent findings",
abstract = "PURPOSE OF REVIEW: Discovery of a system of pattern recognition receptors has opened an entirely new field in inflammation research. This paper reviews studies from the last 18 months focusing on mechanisms of immune stimulation after exposure to microbial components and other exposures that induce or modulate innate immune responses. RECENT FINDINGS: Perhaps the most studied pattern recognition receptor response pathway is endotoxin upregulation of cytokine production via lipopolysaccharide binding protein (LBP), soluble and membrane bound CD14, v-myb-dependent gene 2 (MD-2) and toll-like receptor (TLR) 4. This interaction, and that of synthetic TLR2-agonist (Pam3Cys4) with toll-like receptors TLR1 and TLR2, has recently been characterized at the structural level, and has been confirmed by a blunted response in knockout mice. Dectin-1 recognizes the hyphal form, but not the spores of Aspergillus fumigatus, giving the first known function of the dectin receptor. Martinez has hypothesized that inconsistencies relating to the protective effect of lipopolysaccharide exposure on allergy might be explained by a gene-environment interaction. SUMMARY: We are on the brink of understanding the complex nature and interaction of the pattern recognition receptors and the cellular events following their binding of ligands. Further elucidation of gene-environment interactions will probably lead to important discoveries in the near future.",
author = "Torben Sigsgaard and Hoffmann, {Hans J{\"u}rgen} and Thorne, {Peter S}",
year = "2008",
doi = "10.1097/ACI.0b013e3282f82492",
language = "English",
volume = "8",
pages = "120--5",
journal = "Current Opinion in Allergy and Clinical Immunology",
issn = "1528-4050",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "2",

}

RIS

TY - JOUR

T1 - The role of innate immunity in occupational allergy: recent findings

AU - Sigsgaard, Torben

AU - Hoffmann, Hans Jürgen

AU - Thorne, Peter S

PY - 2008

Y1 - 2008

N2 - PURPOSE OF REVIEW: Discovery of a system of pattern recognition receptors has opened an entirely new field in inflammation research. This paper reviews studies from the last 18 months focusing on mechanisms of immune stimulation after exposure to microbial components and other exposures that induce or modulate innate immune responses. RECENT FINDINGS: Perhaps the most studied pattern recognition receptor response pathway is endotoxin upregulation of cytokine production via lipopolysaccharide binding protein (LBP), soluble and membrane bound CD14, v-myb-dependent gene 2 (MD-2) and toll-like receptor (TLR) 4. This interaction, and that of synthetic TLR2-agonist (Pam3Cys4) with toll-like receptors TLR1 and TLR2, has recently been characterized at the structural level, and has been confirmed by a blunted response in knockout mice. Dectin-1 recognizes the hyphal form, but not the spores of Aspergillus fumigatus, giving the first known function of the dectin receptor. Martinez has hypothesized that inconsistencies relating to the protective effect of lipopolysaccharide exposure on allergy might be explained by a gene-environment interaction. SUMMARY: We are on the brink of understanding the complex nature and interaction of the pattern recognition receptors and the cellular events following their binding of ligands. Further elucidation of gene-environment interactions will probably lead to important discoveries in the near future.

AB - PURPOSE OF REVIEW: Discovery of a system of pattern recognition receptors has opened an entirely new field in inflammation research. This paper reviews studies from the last 18 months focusing on mechanisms of immune stimulation after exposure to microbial components and other exposures that induce or modulate innate immune responses. RECENT FINDINGS: Perhaps the most studied pattern recognition receptor response pathway is endotoxin upregulation of cytokine production via lipopolysaccharide binding protein (LBP), soluble and membrane bound CD14, v-myb-dependent gene 2 (MD-2) and toll-like receptor (TLR) 4. This interaction, and that of synthetic TLR2-agonist (Pam3Cys4) with toll-like receptors TLR1 and TLR2, has recently been characterized at the structural level, and has been confirmed by a blunted response in knockout mice. Dectin-1 recognizes the hyphal form, but not the spores of Aspergillus fumigatus, giving the first known function of the dectin receptor. Martinez has hypothesized that inconsistencies relating to the protective effect of lipopolysaccharide exposure on allergy might be explained by a gene-environment interaction. SUMMARY: We are on the brink of understanding the complex nature and interaction of the pattern recognition receptors and the cellular events following their binding of ligands. Further elucidation of gene-environment interactions will probably lead to important discoveries in the near future.

U2 - 10.1097/ACI.0b013e3282f82492

DO - 10.1097/ACI.0b013e3282f82492

M3 - Journal article

C2 - 18317019

VL - 8

SP - 120

EP - 125

JO - Current Opinion in Allergy and Clinical Immunology

JF - Current Opinion in Allergy and Clinical Immunology

SN - 1528-4050

IS - 2

ER -