Hans Jürgen Hoffmann

Immunotoxicity and environment: immunodysregulation and systemic inflammation in children

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Lilian Calderón-Garcidueñas, Denmark
  • Mercedes Macías-Parra, Denmark
  • Hans Jürgen Hoffmann
  • Gildardo Valencia-Salazar, Denmark
  • Carlos Henríquez-Roldán, Denmark
  • Norma Osnaya, Denmark
  • Ofelia Camacho-Del Monte, Denmark
  • Gerardo Barragán-Mejía, Denmark
  • Rodolfo Villarreal-Calderon, Denmark
  • Lina Romero, Denmark
  • Margarita Granada-Macías, Denmark
  • Ricardo Torres-Jardón, Denmark
  • Humberto Medina-Cortina, Denmark
  • Robert R Maronpot, Denmark
  • The Department og Pulmunary Medicine
Environmental pollutants, chemicals, and drugs have an impact on children's immune system development. Mexico City (MC) children exposed to significant concentrations of air pollutants exhibit chronic respiratory inflammation, systemic inflammation, neuroinflammation, and cognitive deficits. We tested the hypothesis that exposure to severe air pollution plays a role in the immune responses of asymptomatic, apparently healthy children. Blood measurements for markers of immune function, inflammatory mediators, and molecules interacting with the lipopolysaccharide recognition complex were obtained from two cohorts of matched children (aged 9.7 +/- 1.2 years) from southwest Mexico City (SWMC) (n = 66) and from a control city (n = 93) with criteria pollutant levels below current standards. MC children exhibited significant decreases in the numbers of natural killer cells (p = .003) and increased numbers of mCD14+ monocytes (p < .001) and CD8+ cells (p = .02). Lower concentrations of interferon gamma (p = .009) and granulocyte-macrophage colony-stimulating factor (p < .001), an endotoxin tolerance-like state, systemic inflammation, and an anti-inflammatory response were also present in the highly exposed children. C-reactive protein and the prostaglandin E metabolite levels were positively correlated with twenty-four- and forty-eight-hour cumulative concentrations of PM(2.5). Exposure to urban air pollution is associated with immunodysregulation and systemic inflammation in children and is a major health threat.
Original languageEnglish
JournalToxicologic Pathology
Pages (from-to)161-9
Number of pages8
Publication statusPublished - 2009

    Research areas

  • Air Pollutants, Air Pollution, Case-Control Studies, Child, Cohort Studies, Environmental Exposure, Female, Humans, Inflammation, Inhalation Exposure, Male, Mexico, Particle Size, Particulate Matter, Retrospective Studies, Urban Health

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