Hans Jürgen Hoffmann

CD4dimCD25bright Treg cell frequencies above a standardized gating threshold are similar in asthmatics and controls

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Hans Jürgen Hoffmann
  • Tine M Malling, Denmark
  • Ayfer Topcu, Denmark
  • Lars P. Ryder, Klinisk Immunologi, Rigshospitalet, Denmark
  • Kaspar Rene Nielsen, Institut for Klinisk Medicin - Klinisk Immunologi, Aalborg Sygehus, Denmark
  • Kim Varming, Denmark
  • Ronald Dahl
  • Øyvind Omland
  • ,
  • Torben Sigsgaard
  • The Department og Pulmunary Medicine
  • Arbejdsmedicinsk Klinik, Aalborg Sygehus
  • Klinisk Immunologi, Aalborg Sygehus
  • Institute of Environmental and Occupational Medicine
Thymus selected CD4(+)CD25(bright) natural regulatory Treg cells expressing FOXP3 may contribute to control of immune responses. No unique markers have been available to identify and characterize Treg. We present a gating strategy that allows enumeration of Treg on the basis of CD4 and CD25 and investigate whether asthmatics have fewer Treg than controls.
Original languageEnglish
JournalCytometry. Part A
Pages (from-to)371-8
Number of pages8
Publication statusPublished - 1 Jun 2007

    Research areas

  • Adult, Algorithms, Antigens, CD4, Asthma, Case-Control Studies, Cell Count, Cell Separation, Female, Flow Cytometry, Forkhead Transcription Factors, HLA-DR Antigens, Humans, Image Interpretation, Computer-Assisted, Immunophenotyping, Interleukin-2 Receptor alpha Subunit, Interleukin-7 Receptor alpha Subunit, Male, Reproducibility of Results, T-Lymphocytes, Regulatory

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