Aarhus University Seal / Aarhus Universitets segl

Hans Henrik Gad

  1. 2020
  2. Published

    Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. / Major, Jack; Crotta, Stefania; Llorian, Miriam; McCabe, Teresa M; Gad, Hans Henrik; Priestnall, Simon L; Hartmann, Rune; Wack, Andreas.

    In: Science (New York, N.Y.), Vol. 369, No. 6504, 08.2020, p. 712-717.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. E-pub ahead of print

    Inhibition of SARS-CoV-2 by type I and type III interferons. / Felgenhauer, Ulrike; Schoen, Andreas; Gad, Hans Henrik; Hartmann, Rune; Schaubmar, Andreas R; Failing, Klaus; Drosten, Christian; Weber, Friedemann.

    In: The Journal of Biological Chemistry, 25.06.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. E-pub ahead of print

    Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation. / Jørgensen, Sofie E; Christiansen, Mette; Høst, Christian; Glerup, Mia; Mahler, Birgitte; Lausten, Mira M; Gad, Hans Henrik; Hartmann, Rune; Herlin, Troels; Mogensen, Trine H.

    In: Rheumatology (Oxford, England), 18.06.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Length dependent activation of OAS proteins by dsRNA. / Wang, Yinbiao; Holleufer, Andreas; Gad, Hans Henrik; Hartmann, Rune.

    In: Cytokine, Vol. 126, 154867, 01.02.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    The IFNL4 Gene Is a Noncanonical Interferon Gene with a Unique but Evolutionarily Conserved Regulation. / Zhou, Hao; Møhlenberg, Michelle; Terczyńska-Dyla, Ewa; Winther, Kasper Grønbjerg; Hansen, Nanna Hougaard; Vad-Nielsen, Johan; Laloli, Laura; Dijkman, Ronald; Nielsen, Anders Lade; Gad, Hans Henrik; Hartmann, Rune.

    In: Journal of Virology, Vol. 94, No. 5, 2020, p. e01535-19.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. 2019
  8. Published

    Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza. / Thomsen, Michelle M; Jørgensen, Sofie E; Gad, Hans Henrik; Storgaard, Merete; Gjedsted, Jakob; Christiansen, Mette; Hartmann, Rune; Mogensen, Trine H.

    In: Medical Microbiology and Immunology, Vol. 208, No. 6, 12.2019, p. 869-876.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza. / Thomsen, Michelle M; Jørgensen, Sofie E; Storgaard, Merete; Kristensen, Lasse S; Gjedsted, Jakob; Christiansen, Mette; Gad, Hans Henrik; Hartmann, Rune; Mogensen, Trine H.

    In: European Journal of Immunology, Vol. 49, No. 11, 11.2019, p. 2111-2114.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debateResearchpeer-review

  10. Published

    Type I and type III interferons differ in their adjuvant activities for influenza vaccines. / Ye, Liang; Ohnemus, Annette; Ong, Li Ching; Gad, Hans Henrik; Hartmann, Rune; Lycke, Nils; Staeheli, Peter.

    In: Journal of Virology, Vol. 93, No. 23, e01262-19, 11.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    The Influence of the rs30461 Single Nucleotide Polymorphism on IFN-λ1 Activity and Secretion. / Møhlenberg, Michelle; Gad, Hans Henrik; Hartmann, Rune.

    In: Journal of Interferon & Cytokine Research, Vol. 39, No. 10, 10.2019, p. 661-667.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. / Ye, Liang; Schnepf, Daniel; Becker, Jan; Ebert, Karolina; Tanriver, Yakup; Bernasconi, Valentina; Gad, Hans Henrik; Hartmann, Rune; Lycke, Nils; Staeheli, Peter.

    In: Nature Immunology, Vol. 20, No. 5, 05.2019, p. 593-601.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. 2018
  14. Published

    Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ. / Jacobs, Sophie; Wavreil, Fanny; Schepens, Bert; Gad, Hans Henrik; Hartmann, Rune; Rocha-Pereira, Joana; Neyts, Johan; Saelens, Xavier; Michiels, Thomas.

    In: Journal of Interferon & Cytokine Research, Vol. 38, No. 11, 14.11.2018, p. 469–479.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Defective RNA sensing by RIG-I in severe influenza virus infection. / Jørgensen, Sofie Eg; Christiansen, Mette; Ryø, Laura Barrett; Gad, Hans Henrik; Gjedsted, Jakob; Staeheli, Peter; Mikkelsen, Jacob Giehm; Storgaard, Merete; Hartmann, Rune; Mogensen, Trine Hyrup.

    In: Clinical and Experimental Immunology, Vol. 192, No. 3, 06.2018, p. 366-376.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission. / Klinkhammer, Jonas; Schnepf, Daniel; Ye, Liang; Schwaderlapp, Marilena; Gad, Hans Henrik; Hartmann, Rune; Garcin, Dominique; Mahlakõiv, Tanel; Staeheli, Peter.

    In: eLife, Vol. 7, e33354, 13.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. / Bussey, Kendra A.; Lau, Ulrike; Schumann, Sophie; Gallo, Antonio; Osbelt, Lisa; Stempel, Markus; Arnold, Christine; Wissing, Josef; Gad, Hans Henrik; Hartmann, Rune; Brune, Wolfram; Jänsch, Lothar; Whitehouse, Adrian; Brinkmann, Melanie M.

    In: PLOS Pathogens, Vol. 14, No. 3, e1006937, 02.03.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. 2017
  19. Published

    Characterization of IFNL4 promoters from different species. / Zhou, Hao; Terczynska-Dyla, Ewa; Mohlenberg, Michelle; Gad, Hans Henrik; Hartmann, Rune.

    In: Cytokine, Vol. 100, 12.2017, p. 143.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  20. Published

    IFN-lambda enhances IgG1 antibody production after intranasal immunization by a TSLP-dependent mechanism. / Staeheli, Peter; Ye, Liang; Schnepf, Daniel; Becker, Jan; Ebert, Karolina; Bernasconi, Valentina; Gad, Hans A.; Tanriver, Yakup; Hartmann, Rune; Lycke, Nils.

    In: Cytokine, Vol. 100, 12.2017, p. 152-153.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  21. Published

    Mutation of arginine 285 in IRF3 to glutamine selectively impairs activation of IRF3 by STING and TRIF dependent pathways. / Andersen, Line Lykke; Dalskov, Louise Kragh; Gad, Hans Henrik; Mogensen, Trine Hyrup; Hartmann, Rune.

    In: Cytokine, Vol. 100, 12.2017, p. 31.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  22. Published

    Unique and Overlapping Actions of Type I and III IFNs in Influenza A Virus Infection and Implications for Therapy. / Davidson, Sophia; McCabe, Teresa M.; Crotta, Stefania; Gad, Hans Henrik; Hartmann, Rune; Hessel, Edith M.; Beinke, Soren; Wack, Andreas.

    In: Cytokine, Vol. 100, 12.2017, p. 123-124.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  23. 2016
  24. Published

    IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment. / Davidson, Sophia; McCabe, Teresa M.; Crotta, Stefania; Gad, Hans Henrik; Hessel, Edith M.; Beinke, Soren; Hartmann, Rune; Wack, Andreas.

    In: EMBO Molecular Medicine, Vol. 8, No. 9, 01.09.2016, p. 1099-1112.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik; Bak, Rasmus O; Jakobsen, Martin R; Jiang, Zhaozaho; Hansen, Anne Louise; Jensen, Simon K; Sun, Chenglong; Thomsen, Martin K; Laustsen, Anders; Nielsen, Camilla G; Severinsen, Kasper; Xiong, Yingluo; Burdette, Dara L; Hornung, Veit; Lebbink, Robert Jan; Duch, Mogens; Fitzgerald, Katherine A; Bahrami, Shervin; Mikkelsen, Jacob Giehm; Hartmann, Rune; Paludan, Søren R.

    In: Nature Communications, Vol. 7, 10680, 19.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. 2015
  27. Published

    Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells. / Lauber, Chris; Vieyres, Gabrielle; Terczynska-Dyla, Ewa; Kusuma, Angga; Dijkman, Ronald; Gad, Hans Henrik; Akhtar, Hashaam; Geffers, Robert; Vondran, Florian; Thiel, Volker; Kaderali, Lars; Pietschmann, Thomas; Hartmann, Rune.

    In: Genes and Immunity, Vol. 16, 16.09.2015, p. 414-421.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane. / Siupka, P; Hamming, O T; Kang, L; Gad, H H; Hartmann, R.

    In: Genes and Immunity, Vol. 16, No. 6, 09.2015, p. 405-413.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. / Ibsen, Mikkel Søes; Gad, Hans Henrik; Andersen, Line Lykke; Hornung, Veit; Julkunen, Ilkka; Sarkar, Saumendra N; Hartmann, Rune.

    In: Nucleic Acids Research, Vol. 43, No. 10, 26.05.2015, p. 5236-5248.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Rapid Uptake and Inhibition of Viral Propagation by Extracellular OAS1. / Thavachelvam, Karthiga; Gad, Hans Henrik; Ibsen, Mikkel Søes; Desprès, Philippe; Hokland, Marianne; Hartmann, Rune; Kristiansen, Helle.

    In: Journal of Interferon & Cytokine Research, Vol. 35, No. 2, 05.05.2015, p. 359-366.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S; Kofod-Olsen, Emil; Narita, Ryo; Jørgensen, Sofie E; Skipper, Kristian A; Höning, Klara; Gad, Hans Henrik; Østergaard, Lars; Ørntoft, Torben F; Hornung, Veit; Paludan, Søren R; Mikkelsen, Jacob Giehm; Fujita, Takashi; Christiansen, Mette; Hartmann, Rune; Mogensen, Trine H.

    In: Journal of Experimental Medicine, Vol. 212, No. 9, 2015, p. 1371-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. 2014
  33. Published

    The 2'-5'-Oligoadenylate Synthetase 3 Enzyme Potently Synthesizes the 2'-5'-Oligoadenylates Required for RNase L Activation. / Ibsen, Mikkel Søes; Gad, Hans Henrik; Thavachelvam, Karthiga; Boesen, Thomas; Desprès, Philippe; Hartmann, Rune.

    In: Journal of Virology, Vol. 88, No. 24, 15.12.2014, p. 14222-14231.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. 2012
  35. Published

    Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. / Bouraï, Mehdi; Lucas-Hourani, Marianne; Gad, Hans Henrik; Drosten, Christian; Jacob, Yves; Tafforeau, Lionel; Cassonnet, Patricia; Jones, Louis M; Judith, Delphine; Couderc, Thérèse; Lecuit, Marc; André, Patrice; Kümmerer, Beate Mareike; Lotteau, Vincent; Desprès, Philippe; Tangy, Frédéric; Vidalain, Pierre-Olivier.

    In: Indian Journal of Virology, Vol. 86, No. 6, 2012, p. 3121-34.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    The E2-E166K substitution restores Chikungunya virus growth in OAS3 expressing cells by acting on viral entry. / Gad, Hans Henrik; Paulous, Sylvie; Belarbi, Essia; Diancourt, Laure; Drosten, Christian; Kümmerer, Beate M; Plate, Aileen E; Caro, Valérie; Desprès, Philippe.

    In: Virology: Research and Treatment, Vol. 434, No. 1, 2012, p. 27-37.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. 2011
  38. Published

    The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. / Kristiansen, Helle; Gad, Hans Henrik; Larsen, Signe Eskildsen; Despres, Philippe; Hartmann, Rune.

    In: Journal of Interferon & Cytokine Research, Vol. 31, No. 1, 12.01.2011, p. 41-47.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. 2010
  40. Published

    The structure of human interferon lambda and what it has taught us. / Gad, Hans Henrik; Hamming, Ole Jensen; Hartmann, Rune.

    In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 30, No. 8, 01.08.2010, p. 565-71.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. Published

    Selection of a novel and highly specific tumor necrosis factor alpha (TNFalpha) antagonist : insight from the crystal structure of the antagonist-TNFalpha complex. / Byla, Povilas; Andersen, Mikkel H; Holtet, Thor L; Jacobsen, Helle; Munch, Mette; Gad, Hans Henrik; Thøgersen, Hans Christian; Gad, Hans Henrik; Hartmann, Rune.

    In: Journal of Biological Chemistry, Vol. 285, No. 16, 16.04.2010, p. 12096-12100.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. Published

    Lambda Interferons: New Cytokines with Old Functions. / Hamming, Ole Jensen; Gad, Hans Henrik; Hartmann, Rune.

    In: Pharmaceuticals, Vol. 3, No. 4, 2010, p. 795.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. 2009
  44. Published

    Human interferon-lambda3 is a potent member of the type III interferon family. / Dellgren, C; Gad, Hans Henrik; Hamming, O J; Melchjorsen, J; Hartmann, R.

    In: Genes and Immunity, Vol. 87, No. 10, 2009.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    Interferon-{lambda} Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family. / Gad, Hans Henrik; Dellgren, Christoffer; Hamming, Ole J; Vends, Susanne; Paludan, Søren Riis; Hartmann, Rune.

    In: Journal of Biological Chemistry, Vol. 284, No. 31, 2009, p. 20869-75.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review