Hamidreza Ardalani

PhD Student

Hamidreza Ardalani

Profile

I received my M.Sc. degree in chemistry of medicinal plants where my research centered on effects of plant’s hormones on biochemical responses at IAU, Iran. Meantime, I was involved in the researches about the clinical efficacy of plant’s secondary metabolites on hyperlipidemia, hypertension and diabetes. As a research assistant, I conducted a study on metabolite profiling of endophytic fungi to discover antidiabetic and antibiotic compounds at University of Copenhagen, Denmark where I validated a high-resolution method to find the antibacterial bioactive compounds from fungus’s complex crude extract. Subsequently, I started my Ph.D. at Aarhus University, Denmark to study the uptake and metabolization of phytochemicals and pesticides in honey bees. Currently, I endeavor to clarify some agro-chemical inquiries with combination of state-of-the-art techniques such as chromatography, mass spectrometry, RT-qPCR and metabolomics in Fomsgaard’s lab at Department of Agroecology, Aarhus University, Denmark.

 

PhD project: Uptake and metabolisation of phytochemicals and pesticides in honey bees

Aims: Honey bees are ideal pollinators and subject to numerous stresses such as reduced flower diversity, new parasites, and chronical exposure to agrochemicals. In this project, I attempt to investigate the effects of plant secondary metabolites (PSMs) on the detoxification system of honey bees and the sacbrood virus (SBV) level when the bees are co-exposed to selected pesticides. The combination of analytical techniques (LC-Qtrap-MS, GC-TOF-MS, UPLC-Orbitrap-MS/MS, NMR), biological approaches (RT-qPCR), and metabolomics proceedings as a state-of-the-art will enrich a comprehensive ambience to clarify some agro-ecological questions. Investigation of how PSMs can up-regulate bees' systems to detoxify xenobiotics and identification of the enzymes which are involved in this process, can elucidate how bees face the toxicity of chemicals in an agricultural settings.

 

Research interests:

Metabolomics

Natural products chemistry

Chemical ecology

Toxicology

ID: 118840795