Research output per year
Research output per year
- 1 - 50 out of 53 results
Search results
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2023
An animal-free preclinical drug screening platform based on human precision-cut kidney slices
Mutsaers, H. A. M., Jensen, M. S., Kresse, J.-C., Tingskov, S. J., Madsen, M. G. & Nørregaard, R., Mar 2023, In: BMC Research Notes. 16, 1, 6 p., 39.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
Nørregaard, R., Mutsaers, H. A. M., Frøkiær, J. & Kwon, T. H., Oct 2023, In: Physiological Reviews. 103, 4, p. 2827-2872 46 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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Standardized Protocol for the Preparation of Precision-Cut Kidney Slices: A Translational Model of Renal Fibrosis
Jensen, M. S., Merrild, C., Nørregaard, R., Olinga, P. & Mutsaers, H. A. M., 2023, In: Methods in molecular biology (Clifton, N.J.). 2664, p. 123-134 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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The impact of fibrotic diseases on global mortality from 1990 to 2019
Mutsaers, H. A. M., Merrild, C., Nørregaard, R. & Plana-Ripoll, O., Nov 2023, In: Journal of Translational Medicine. 21, 1, 818.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review
Open Access -
Transcutaneous measurement of renal function in two rodent models of obstructive nephropathy
Jensen, M. S., de Araujo, I. B. B. A., Mutsaers, H. A. M. & Nørregaard, R., Jun 2023, In: BMC Research Notes. 16, 1, 8 p., 119.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2022
EP1 receptor antagonism mitigates early and late stage renal fibrosis
Kresse, J.-C., Mutsaers, H. A. M., Jensen, M. S., Tingskov, S. J., Gebauer Madsen, M., Nejsum, L. N., Prætorius Øhrwald, H. & Nørregaard, R., Mar 2022, In: Acta Physiologica (Print). 234, 3, 21 p., e13780.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
GLP-1-Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight
Monti, G., Gomes Moreira, D., Richner, M., Mutsaers, H. A. M., Ferreira, N. & Jan, A., Jul 2022, In: Cells. 11, 13, 2023.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access -
Prostaglandin E2 receptors as therapeutic targets in renal fibrosis
Mutsaers, H. A. M. & Nørregaard, R., Jan 2022, In: Kidney Research and Clinical Practice. 41, 1, p. 4-13 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access1 Citation (Scopus) -
2021
Editorial: Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets
Mutsaers, H. A. M., Nørregaard, R. & Olinga, P., Nov 2021, In: Frontiers in medicine. 8, 3 p., 793507.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
Open Access -
Local inhibition of indoleamine 2, 3-dioxygenase mitigates renal fibrosis
Jensen, C. G., Jensen, M. S., Tingskov, S. J., Olinga, P., Nørregaard, R. & Mutsaers, H. A. M., Aug 2021, In: Biomedicines. 9, 8, 856.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Tamoxifen attenuates renal fibrosis in human kidney slices and rats subjected to unilateral ureteral obstruction
Tingskov, S. J., Jensen, M. S., Pedersen, C. E. T., de Araujo, I. B. B. A., Mutsaers, H. A. M. & Nørregaard, R., Jan 2021, In: Biomedicine and Pharmacotherapy. 133, 111003.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2020
Estrogen regulates aquaporin-2 expression in the kidney
Tingskov, S. J., Mutsaers, H. A. M. & Nørregaard, R., 2020, Aquaporin Regulation. Litwack, G. (ed.). Elsevier, Vol. 112. p. 243-264 22 p. (Vitamins and hormones).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
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Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices
Bigaeva, E., Gore, E., Mutsaers, H. A. M., Oosterhuis, D., Kim, Y. O., Schuppan, D., Bank, R. A., Boersema, M. & Olinga, P., Jan 2020, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 1, 165582.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)32 Downloads (Pure) -
Host microbiota dictates the proinflammatory impact of LPS in the murine liver
Suriguga, S., Luangmonkong, T., Mutsaers, H. A. M., Groothuis, G. M. M. & Olinga, P., Sept 2020, In: Toxicology in Vitro. 67, 104920.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile28 Downloads (Pure) -
Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis
Bigaeva, E., Stribos, E. G. D., Mutsaers, H. A. M., Piersma, B., Leliveld, A. M., de Jong, I. J., Bank, R. A., Seelen, M. A., van Goor, H., Wollin, L., Olinga, P. & Boersema, M., Jan 2020, In: American Journal of Physiology - Renal Physiology. 318, 1, p. F117-F134 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
1 Citation (Scopus) -
Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs
Iswandana, R., Pham, B. T., Suriguga, S., Luangmonkong, T., van Wijk, L. A., Jansen, Y. J. M., Oosterhuis, D., Maria Mutsaers, H. A. & Olinga, P., 2020, In: Inflammatory Bowel Diseases. 26, 5, p. 678-686 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile17 Downloads (Pure) -
Phenformin attenuates renal injury in unilateral ureteral obstructed mice without affecting immune cell infiltration
Nørgård, M., Christensen, M., Mutsaers, H. A. M. & Nørregaard, R., Apr 2020, In: Pharmaceutics. 12, 4, 301.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Predictive value of precision-cut kidney slices as an ex vivo screening platform for therapeutics in human renal fibrosis
Bigaeva, E., Cavanzo, N. P., Stribos, E. G. D., de Jong, A. J., Biel, C., Mutsaers, H. A. M., Jensen, M. S., Nørregaard, R., Leliveld, A. M., de Jong, I. J., Hillebrands, J. L., van Goor, H., Boersema, M., Bank, R. A. & Olinga, P., May 2020, In: Pharmaceutics. 12, 5, 31 p., 459.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair
Schreurs, M., Suttorp, C. M., Mutsaers, H. A. M., Kuijpers-Jagtman, A. M., Von den Hoff, J. W., Ongkosuwito, E. M., Carvajal Monroy, P. L. & Wagener, F. A. D. T. G., Jan 2020, In: Medicinal Research Reviews. 40, 1, p. 9-26 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile32 Downloads (Pure) -
2019
Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices
Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T. H. & Nørregaard, R., Sept 2019, In: Acta Physiologica. 227, 1, 13 p., e13291.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)77 Downloads (Pure) -
A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J. & Olinga, P., Mar 2019, In: Nutrients. 11, 3, 507.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study
Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M. & Olinga, P., Sept 2019, In: Toxicology in Vitro. 59, p. 312-321 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile84 Downloads (Pure) -
2018
In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β
Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., de Jong, K. P., Mutsaers, H. A. M. & Olinga, P., Sept 2018, In: Toxicology and Applied Pharmacology. 355, p. 127-137 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus) -
Regional Differences in Human Intestinal Drug Metabolism
Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., Mutsaers, H. A. M. & Olinga, P., 1 Dec 2018, In: Drug Metabolism and Disposition. 46, 12, p. 1879-1885 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Targeting oxidative stress for the treatment of liver fibrosis
Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P. & Boersema, M., 2018, Reviews of Physiology, Biochemistry and Pharmacology. Springer, p. 71-102 32 p. (Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
6 Citations (Scopus) -
2017
Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis
Luangmonkong, T., Suriguga, S., Bigaeva, E., Boersema, M., Oosterhuis, D., de Jong, K. P., Schuppan, D., Mutsaers, H. A. M. & Olinga, P., Sept 2017, In: British Journal of Pharmacology. 174, 18, p. 3107-3117 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis
Stribos, E. G. D., Seelen, M. A., van Goor, H., Olinga, P. & Mutsaers, H. A. M., 2017, In: Frontiers in Physiology. 8, DEC, p. 1026 1026.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Non-invasive quantification of collagen turnover in renal transplant recipients
Stribos, E. G. D., Nielsen, S. H., Brix, S., Karsdal, M. A., Seelen, M. A., van Goor, H., Bakker, S. J. L., Olinga, P., Mutsaers, H. A. M. & Genovese, F., 2017, In: PLOS ONE. 12, 4, p. e0175898 e0175898.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2016
Editorial: Organ Fibrosis: Triggers, Pathways, and Cellular Plasticity
Mutsaers, H. A. M. & Olinga, P., 2016, In: Frontiers in medicine. 3, NOV, p. 55 55.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis
Westra, I. M., Mutsaers, H. A. M., Luangmonkong, T., Hadi, M., Oosterhuis, D., de Jong, K. P., Groothuis, G. M. M. & Olinga, P., Sept 2016, In: Toxicology in Vitro. 35, p. 77-85 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Organ- and species-specific biological activity of rosmarinic acid
Iswandana, R., Pham, B. T., van Haaften, W. T., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M. & Olinga, P., 1 Apr 2016, In: Toxicology in Vitro. 32, p. 261-268 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
29 Citations (Scopus) -
Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis
Stribos, E. G. D., Luangmonkong, T., Leliveld, A. M., De Jong, I. J., Van Son, W. J., Hillebrands, J. L., Seelen, M. A., Van Goor, H., Olinga, P. & Mutsaers, H. A. M., 1 Apr 2016, In: Translational Research. 170, p. 8-16.e1Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
26 Citations (Scopus) -
Renal fibrosis in precision-cut kidney slices
Stribos, E. G. D., Hillebrands, J.-L., Olinga, P. & Mutsaers, H. A. M., 5 Nov 2016, In: European Journal of Pharmacology. 790, p. 57-61 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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Uremic Solutes in Chronic Kidney Disease and Their Role in Progression
van den Brand, J. A. J. G., Mutsaers, H. A. M., van Zuilen, A. D., Blankestijn, P. J., van den Broek, P. H., Russel, F. G. M., Masereeuw, R. & Wetzels, J. F. M., 2016, In: PLOS ONE. 11, 12, p. e0168117 e0168117.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2015
Chronic kidney disease and fibrosis: The role of uremic retention solutes
Mutsaers, H. A. M., Stribos, E. G. D., Glorieux, G., Vanholder, R. & Olinga, P., 2015, In: Frontiers in medicine. 2, AUG, 60.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access44 Citations (Scopus) -
Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology
Mutsaers, H. A. M., Caetano-Pinto, P., Seegers, A. E. M., Dankers, A. C. A., van den Broek, P. H. H., Wetzels, J. F. M., van den Brand, J. A. J. G., van den Heuvel, L. P., Hoenderop, J. G., Wilmer, M. J. G. & Masereeuw, R., 1 Oct 2015, In: Toxicology in Vitro. 29, 7, p. 1868-1877 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
35 Citations (Scopus) -
The authors reply
Mutsaers, H. A. M., Masereeuw, R. & Olinga, P., 3 Sept 2015, In: Kidney International. 88, 3, p. 637 1 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
Open Access -
The influence of dietary protein intake on mammalian tryptophan and phenolic metabolites
Poesen, R., Mutsaers, H. A. M., Windey, K., Van Den Broek, P. H., Verweij, V., Augustijns, P., Kuypers, D., Jansen, J., Evenepoel, P., Verbeke, K., Meijers, B. & Masereeuw, R., 15 Oct 2015, In: PLOS ONE. 10, 10, 0140820.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access57 Citations (Scopus) -
2014
Altered tryptophan metabolism and CKD-associated fatigue
Mutsaers, H. A. M., Masereeuw, R. & Olinga, P., 5 Nov 2014, In: Kidney International. 86, 5, p. 1061-1062 2 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
Open Access11 Citations (Scopus) -
A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue
Jansen, J., Schophuizen, C. M. S., Wilmer, M. J., Lahham, S. H. M., Mutsaers, H. A. M., Wetzels, J. F. M., Bank, R. A., Van den Heuvel, L. P., Hoenderop, J. G. & Masereeuw, R., 15 Apr 2014, In: Experimental Cell Research. 323, 1, p. 87-99 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
69 Citations (Scopus) -
Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions
Mutsaers, H. A. M., Levtchenko, E. N., Martinerie, L., Pertijs, J. C. L. M., Allegaert, K., Devriendt, K., Masereeuw, R., Monnens, L. A. H. & Lombès, M., Jul 2014, In: Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1361-E1367Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access4 Citations (Scopus) -
The Kidney and Uremic Toxin Removal: Glomerulus or Tubule?
Masereeuw, R., Mutsaers, H. A. M., Toyohara, T., Abe, T., Jhawar, S., Sweet, D. H. & Lowenstein, J., Mar 2014, In: Seminars in Nephrology. 34, 2, p. 191-208 18 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
94 Citations (Scopus) -
2013
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)
Dankers, A. C. A., Mutsaers, H. A. M., Dijkman, H. B. P. M., van den Heuvel, L. P., Hoenderop, J. G., Sweep, F. C. G. J., Russel, F. G. M. & Masereeuw, R., Oct 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 10, p. 1715-1722 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access36 Citations (Scopus) -
Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity
Moghadasali, R., Mutsaers, H. A. M., Azarnia, M., Aghdami, N., Baharvand, H., Torensma, R., Wilmer, M. J. G. & Masereeuw, R., Jul 2013, In: Experimental and Toxicologic Pathology. 65, 5, p. 595-600 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access45 Citations (Scopus) -
Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3-4 Chronic Kidney Disease Patients
Mutsaers, H. A. M., Engelke, U. F. H., Wilmer, M. J. G., Wetzels, J. F. M., Wevers, R. A., van den Heuvel, L. P., Hoenderop, J. G. & Masereeuw, R., 7 Aug 2013, In: PLOS ONE. 8, 8, e71199.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access50 Citations (Scopus) -
Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration
Mutsaers, H. A. M., Wilmer, M. J. G., Reijnders, D., Jansen, J., van den Broek, P. H. H., Forkink, M., Schepers, E., Glorieux, G., Vanholder, R., van den Heuvel, L. P., Hoenderop, J. G. & Masereeuw, R., Jan 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 1, p. 142-150 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access93 Citations (Scopus) -
2012
Beware of Janus-faced riddles.
Mutsaers, R., 10 Dec 2012, In: The Medical journal of Australia. 197, 11, p. 672 1 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Cryptography in modern-day medical science
Mutsaers, H. A. M., 2012, In: Medical Journal of Australia. 197, 6, p. 353 1 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Dexamethasone enhances oxidative stress-induced cell death in murine neural stem cells
Mutsaers, H. A. M. & Tofighi, R., Aug 2012, In: Neurotoxicity Research. 22, 2, p. 127-137 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
39 Citations (Scopus) -
2011
Basolateral transport of the uraemic toxin p-cresyl sulfate: Role for organic anion transporters?
Mutsaers, H. A. M., Wilmer, M. J. G., Van Den Heuvel, L. P., Hoenderop, J. G. & Masereeuw, R., Dec 2011, In: Nephrology Dialysis Transplantation. 26, 12, p. 4149 1 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
Open Access17 Citations (Scopus)