Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Impedance planimetric characterization of esophagus in systemic sclerosis patients with severe involvement of esophagus. / Villadsen, Gerda Elisabeth; Storkholm, Jan Henrik; Hendel, L et al.
In: Digestive Diseases and Sciences, Vol. 42, No. 11, 11.1997, p. 2317-26.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Impedance planimetric characterization of esophagus in systemic sclerosis patients with severe involvement of esophagus
AU - Villadsen, Gerda Elisabeth
AU - Storkholm, Jan Henrik
AU - Hendel, L
AU - Vilstrup, H
AU - Gregersen, H
PY - 1997/11
Y1 - 1997/11
N2 - This study was designed to evaluate the distensibility and secondary peristalsis of the esophagus in patients suffering from systemic sclerosis with severe esophageal involvement. Balloon distension with impedance planimetric measurement of luminal cross-sectional area was done 7 and 15 cm above the lower esophageal sphincter in 13 patients and nine healthy controls. The controls were studied both with and without receiving the anticholinergic drug butylscopolamine. The cross-sectional area--pressure relations were nonlinear with the largest cross-sectional area in patients at both measuring sites when compared to controls (P <0.001). The anticholinergic drug butylscopolamine increased the cross-sectional area in controls (P <0.001). The cross-sectional area distensibility, defined as CSA0(-1) delta CSA delta P-1 did not differ between patients and controls. Balloon distensions elicited contractions proximal to the distension site. The amplitude and frequency of contractions at the distal distension site were significantly reduced in the patients when compared to the controls (P <0.05). In conclusion, the distal esophagus is most severely affected in patients with systemic sclerosis with increased cross-sectional area and impaired peristalsis.
AB - This study was designed to evaluate the distensibility and secondary peristalsis of the esophagus in patients suffering from systemic sclerosis with severe esophageal involvement. Balloon distension with impedance planimetric measurement of luminal cross-sectional area was done 7 and 15 cm above the lower esophageal sphincter in 13 patients and nine healthy controls. The controls were studied both with and without receiving the anticholinergic drug butylscopolamine. The cross-sectional area--pressure relations were nonlinear with the largest cross-sectional area in patients at both measuring sites when compared to controls (P <0.001). The anticholinergic drug butylscopolamine increased the cross-sectional area in controls (P <0.001). The cross-sectional area distensibility, defined as CSA0(-1) delta CSA delta P-1 did not differ between patients and controls. Balloon distensions elicited contractions proximal to the distension site. The amplitude and frequency of contractions at the distal distension site were significantly reduced in the patients when compared to the controls (P <0.05). In conclusion, the distal esophagus is most severely affected in patients with systemic sclerosis with increased cross-sectional area and impaired peristalsis.
KW - Adult
KW - Aged
KW - Butylscopolammonium Bromide
KW - Cholinergic Antagonists
KW - Esophageal Diseases
KW - Esophagus
KW - Female
KW - Humans
KW - Male
KW - Manometry
KW - Middle Aged
KW - Peristalsis
KW - Scleroderma, Systemic
M3 - Journal article
C2 - 9398812
VL - 42
SP - 2317
EP - 2326
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 11
ER -