Gerda Elisabeth Villadsen

Gastric emptying: a comparison of three methods

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  • Department of Orthodontics
  • Biomedical Radio Isotope Techniques
  • The Department of Hepatology and Gastroenterology V
  • The Department of Endocrinology and Diabetes
OBJECTIVE: A better understanding of the clinical relevance of delayed gastric emptying (e.g. in diabetes) requires a simple, easily accessible and inexpensive method for measuring it. Two "new" methods for measuring gastric emptying of liquids (the paracetamol absorption test and the 13C-acetate breath test) are compared with the gold standard (gastric emptying scintigraphy (GES)). MATERIAL AND METHODS: The three techniques were used simultaneously in 10 healthy subjects. A gastric emptying time-retention curve was drawn for each technique and the results were compared at the 75%, 50% and 25% retention quartiles. RESULTS: Agreement was found between the paracetamol absorption test and GES (p=0.95; Hotelling's T 2 test). Using the Wagner-Nelson one compartment correction produced a retention curve for the 13C-acetate breath test statistically significantly below GES (p<0.01). CONCLUSION: In healthy subjects, the paracetamol absorption test produced results comparable to those of liquid GES, but not to the results of the 13C-acetate breath test.
Udgivelsesdato: 2007-Oct
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume42
Issue10
Pages (from-to)1182-6
Number of pages4
ISSN0036-5521
DOIs
Publication statusPublished - 2007

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