Frank Holden Mose

Effect of vitamin D supplementation on markers of vascular function: A systematic review and individual participant meta- analysis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Louise A. Beveridge, NHS Tayside
  • ,
  • Faisel Khan, Dundee University
  • ,
  • Allan D. Struthers, Dundee University
  • ,
  • Jane Armitage, Oxford University, Oxford, UK.
  • ,
  • Ilaria Barchetta, Sapienza University of Rome
  • ,
  • Iain Bressendorff, Gentofte Hospital
  • ,
  • Maria Gisella Cavallo, Sapienza University of Rome
  • ,
  • Robert Clarke, Oxford University, Oxford, UK.
  • ,
  • Rinkoo Dalan, Nanyang Technological University
  • ,
  • Gavin Dreyer, Barts Health NHS Trust
  • ,
  • Adam D. Gepner, University of Wisconsin School of Medicine and Public Health
  • ,
  • Nita G. Forouhi, University of Cambridge, School of Clinical Medicine.
  • ,
  • Ryan A. Harris, Medical College of Georgia
  • ,
  • Graham A. Hitman, Goldsmiths, University of London
  • ,
  • Thomas Larsen
  • ,
  • Rajesh Khadgawat, All India Institute of MedicalSciences
  • ,
  • Peter Marckmann, Zealand UniversityHospital
  • ,
  • Frank H. Mose
  • Stefan Pilz, Medical University of Graz
  • ,
  • Alexandra Scholze, Odense Universitetshospital
  • ,
  • Marina Shargorodsky, Tel Aviv University Medical School
  • ,
  • Seth I. Sokol, Jacobi Medical Center
  • ,
  • Hans Stricker, Ospedale La Carita
  • ,
  • Carmine Zoccali, Consiglio Nazionale delle Ricerche
  • ,
  • Miles D. Witham, Dundee University

Background--Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. Methods and Results--We conducted a systematic review and individual participant meta-analysis to examine the effect of vitamin D supplementation on flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo-controlled randomized trials of at least4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial-level metaanalysis was performed using random-effects models; individual participant meta-analyses used a 2-stage analytic strategy, examining effects in prespecified subgroups. 31trials (2751 participants) were included; 29 trials (2641participants) contributed data to trial-level meta-analysis, and24trials (2051 participants) contributed to individual-participant analyses. VitaminD3daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to12 months. Trial-level meta-analysis showed no significant effect of supplementation on macrovascularmeasures(flow-mediateddilatation,0.37%[95%confidenceinterval,-0.23to0.97]; carotid-femoralpulsewavevelocity, 0.00 m/s [95% confidence interval, -0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial-level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues. Conclusions--Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis.

Original languageEnglish
Article numbere008273
JournalJournal of the American Heart Association
Volume7
Issue11
ISSN2047-9980
DOIs
Publication statusPublished - 1 Jun 2018

    Research areas

  • Endothelial function, Paricalcitol, Systematic review, Vascular function, Vitamin D

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