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Finn Skou Pedersen

Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas

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Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. / Jørgensen, Judit Meszaros; Sørensen, Flemming B; Bendix, Knud; Nielsen, Johan L; Funder, Anette; Karkkainen, Marika J; Tainola, Tapio; Sørensen, Annette B; Pedersen, Finn S; D'Amore, Francesco.

In: Leukemia and Lymphoma, Vol. 50, No. 10, 2009, p. 1647-1660.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Jørgensen, JM, Sørensen, FB, Bendix, K, Nielsen, JL, Funder, A, Karkkainen, MJ, Tainola, T, Sørensen, AB, Pedersen, FS & D'Amore, F 2009, 'Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas', Leukemia and Lymphoma, vol. 50, no. 10, pp. 1647-1660. https://doi.org/10.1080/10428190903156729, https://doi.org/10.1080/10428190903156729

APA

Jørgensen, J. M., Sørensen, F. B., Bendix, K., Nielsen, J. L., Funder, A., Karkkainen, M. J., Tainola, T., Sørensen, A. B., Pedersen, F. S., & D'Amore, F. (2009). Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. Leukemia and Lymphoma, 50(10), 1647-1660. https://doi.org/10.1080/10428190903156729, https://doi.org/10.1080/10428190903156729

CBE

Jørgensen JM, Sørensen FB, Bendix K, Nielsen JL, Funder A, Karkkainen MJ, Tainola T, Sørensen AB, Pedersen FS, D'Amore F. 2009. Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. Leukemia and Lymphoma. 50(10):1647-1660. https://doi.org/10.1080/10428190903156729, https://doi.org/10.1080/10428190903156729

MLA

Jørgensen, Judit Meszaros et al. "Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas". Leukemia and Lymphoma. 2009, 50(10). 1647-1660. https://doi.org/10.1080/10428190903156729, https://doi.org/10.1080/10428190903156729

Vancouver

Jørgensen JM, Sørensen FB, Bendix K, Nielsen JL, Funder A, Karkkainen MJ et al. Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. Leukemia and Lymphoma. 2009;50(10):1647-1660. https://doi.org/10.1080/10428190903156729, https://doi.org/10.1080/10428190903156729

Author

Jørgensen, Judit Meszaros ; Sørensen, Flemming B ; Bendix, Knud ; Nielsen, Johan L ; Funder, Anette ; Karkkainen, Marika J ; Tainola, Tapio ; Sørensen, Annette B ; Pedersen, Finn S ; D'Amore, Francesco. / Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. In: Leukemia and Lymphoma. 2009 ; Vol. 50, No. 10. pp. 1647-1660.

Bibtex

@article{165c93e09c5611dea092000ea68e967b,
title = "Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas",
abstract = "The aim of the study was to investigate the expression of angio- and lymphangiogenic molecules (vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4) in non-Hodgkin lymphomas (NHL) treated in the pre-rituximab era. Pre-therapeutic lymph-node biopsies from 155 patients with NHL (64 follicular lymphomas (FLs), 47 de novo diffuse large B-cell lymphomas (DLBCL) and 44 peripheral T-cell lymphomas (PTCL)) were stained by in situ hybridization and immunohistochemistry. Tumor cell expression of VEGF, VEGF-C and their receptors was detected in most of the analyzed biopsies. In FL, diffuse intratumoral VEGF staining correlated with shorter overall survival (OS) (p = 0.008) and diffuse KDR staining was associated with a higher risk of histologic transformation (p = 0.05). In DLBCL, high KDR expression predicted poor treatment response (p = 0.03) and had a significant adverse impact on OS (p < 0.001). In PTCL, diffuse tissue distribution of VEGF mRNA correlated with an unfavorable 5-year OS (p = 0.004).",
author = "J{\o}rgensen, {Judit Meszaros} and S{\o}rensen, {Flemming B} and Knud Bendix and Nielsen, {Johan L} and Anette Funder and Karkkainen, {Marika J} and Tapio Tainola and S{\o}rensen, {Annette B} and Pedersen, {Finn S} and Francesco D'Amore",
year = "2009",
doi = "10.1080/10428190903156729",
language = "English",
volume = "50",
pages = "1647--1660",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor & Francis ",
number = "10",

}

RIS

TY - JOUR

T1 - Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas

AU - Jørgensen, Judit Meszaros

AU - Sørensen, Flemming B

AU - Bendix, Knud

AU - Nielsen, Johan L

AU - Funder, Anette

AU - Karkkainen, Marika J

AU - Tainola, Tapio

AU - Sørensen, Annette B

AU - Pedersen, Finn S

AU - D'Amore, Francesco

PY - 2009

Y1 - 2009

N2 - The aim of the study was to investigate the expression of angio- and lymphangiogenic molecules (vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4) in non-Hodgkin lymphomas (NHL) treated in the pre-rituximab era. Pre-therapeutic lymph-node biopsies from 155 patients with NHL (64 follicular lymphomas (FLs), 47 de novo diffuse large B-cell lymphomas (DLBCL) and 44 peripheral T-cell lymphomas (PTCL)) were stained by in situ hybridization and immunohistochemistry. Tumor cell expression of VEGF, VEGF-C and their receptors was detected in most of the analyzed biopsies. In FL, diffuse intratumoral VEGF staining correlated with shorter overall survival (OS) (p = 0.008) and diffuse KDR staining was associated with a higher risk of histologic transformation (p = 0.05). In DLBCL, high KDR expression predicted poor treatment response (p = 0.03) and had a significant adverse impact on OS (p < 0.001). In PTCL, diffuse tissue distribution of VEGF mRNA correlated with an unfavorable 5-year OS (p = 0.004).

AB - The aim of the study was to investigate the expression of angio- and lymphangiogenic molecules (vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4) in non-Hodgkin lymphomas (NHL) treated in the pre-rituximab era. Pre-therapeutic lymph-node biopsies from 155 patients with NHL (64 follicular lymphomas (FLs), 47 de novo diffuse large B-cell lymphomas (DLBCL) and 44 peripheral T-cell lymphomas (PTCL)) were stained by in situ hybridization and immunohistochemistry. Tumor cell expression of VEGF, VEGF-C and their receptors was detected in most of the analyzed biopsies. In FL, diffuse intratumoral VEGF staining correlated with shorter overall survival (OS) (p = 0.008) and diffuse KDR staining was associated with a higher risk of histologic transformation (p = 0.05). In DLBCL, high KDR expression predicted poor treatment response (p = 0.03) and had a significant adverse impact on OS (p < 0.001). In PTCL, diffuse tissue distribution of VEGF mRNA correlated with an unfavorable 5-year OS (p = 0.004).

U2 - 10.1080/10428190903156729

DO - 10.1080/10428190903156729

M3 - Journal article

C2 - 19701853

VL - 50

SP - 1647

EP - 1660

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 10

ER -