Esben Thyssen Vestergaard

Oral D/L-3-hydroxybutyrate stimulates cholecystokinin- and insulin secretion and slows gastric emptying in healthy males

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Oral D/L-3-hydroxybutyrate stimulates cholecystokinin- and insulin secretion and slows gastric emptying in healthy males. / Rittig, Nikolaj; Svart, Mads; Thomsen, Henrik Holm; Vestergaard, Esben Thyssen; Rehfeld, Jens Frederik; Hartmann, Bolette; Holst, Jens Juul; Johannsen, Mogens; Møller, Niels; Jessen, Niels.

In: The Journal of clinical endocrinology and metabolism, Vol. 105, No. 10, 2020.

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@article{4a98e4e214384621ba10bb8d2936de03,
title = "Oral D/L-3-hydroxybutyrate stimulates cholecystokinin- and insulin secretion and slows gastric emptying in healthy males",
abstract = "BACKGROUND: D-3-hydroxybutyrate (D-3-OHB) is a ketone body that serves as an alternative nutritional fuel but also as an important signalling metabolite. Oral ketone supplements containing D/L-3-OHB are becoming a popular approach to achieve ketosis.AIM: To explore the gut-derived effects of ketone supplements.METHODS: Eight healthy lean male volunteers were investigated on two separate occasions:i)Following an oral D/L-3-OHB consumption (oral) and,ii)following isoketonemic intravenous ketone (D/L-3-OHB) infusion (iv).An acetaminophen test was performed to evaluate gastric emptying and blood samples were obtained consecutively throughout the study period.RESULTS: We show that oral consumption of D/L-3-OHB stimulates cholecystokinin release (p=0.02), elevates insulin (p=0.03) and C-peptide (p<0.001) concentrations, and slows gastric emptying (p=0.01) compared with intravenous D/L-3-OHB administration. Measures of appetite and plasma concentrations of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were unaffected by interventions.CONCLUSION: Our findings show that D/L-3-OHB exert incretin effects and indicate luminal sensing in the gut endothelium. This adds to our understanding of ketones as signalling metabolites and displays the important difference between physiological ketosis and oral ketone supplements.",
author = "Nikolaj Rittig and Mads Svart and Thomsen, {Henrik Holm} and Vestergaard, {Esben Thyssen} and Rehfeld, {Jens Frederik} and Bolette Hartmann and Holst, {Jens Juul} and Mogens Johannsen and Niels M{\o}ller and Niels Jessen",
note = "{\textcopyright} Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2020",
doi = "10.1210/clinem/dgaa483",
language = "English",
volume = "105",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Oral D/L-3-hydroxybutyrate stimulates cholecystokinin- and insulin secretion and slows gastric emptying in healthy males

AU - Rittig, Nikolaj

AU - Svart, Mads

AU - Thomsen, Henrik Holm

AU - Vestergaard, Esben Thyssen

AU - Rehfeld, Jens Frederik

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Johannsen, Mogens

AU - Møller, Niels

AU - Jessen, Niels

N1 - © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2020

Y1 - 2020

N2 - BACKGROUND: D-3-hydroxybutyrate (D-3-OHB) is a ketone body that serves as an alternative nutritional fuel but also as an important signalling metabolite. Oral ketone supplements containing D/L-3-OHB are becoming a popular approach to achieve ketosis.AIM: To explore the gut-derived effects of ketone supplements.METHODS: Eight healthy lean male volunteers were investigated on two separate occasions:i)Following an oral D/L-3-OHB consumption (oral) and,ii)following isoketonemic intravenous ketone (D/L-3-OHB) infusion (iv).An acetaminophen test was performed to evaluate gastric emptying and blood samples were obtained consecutively throughout the study period.RESULTS: We show that oral consumption of D/L-3-OHB stimulates cholecystokinin release (p=0.02), elevates insulin (p=0.03) and C-peptide (p<0.001) concentrations, and slows gastric emptying (p=0.01) compared with intravenous D/L-3-OHB administration. Measures of appetite and plasma concentrations of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were unaffected by interventions.CONCLUSION: Our findings show that D/L-3-OHB exert incretin effects and indicate luminal sensing in the gut endothelium. This adds to our understanding of ketones as signalling metabolites and displays the important difference between physiological ketosis and oral ketone supplements.

AB - BACKGROUND: D-3-hydroxybutyrate (D-3-OHB) is a ketone body that serves as an alternative nutritional fuel but also as an important signalling metabolite. Oral ketone supplements containing D/L-3-OHB are becoming a popular approach to achieve ketosis.AIM: To explore the gut-derived effects of ketone supplements.METHODS: Eight healthy lean male volunteers were investigated on two separate occasions:i)Following an oral D/L-3-OHB consumption (oral) and,ii)following isoketonemic intravenous ketone (D/L-3-OHB) infusion (iv).An acetaminophen test was performed to evaluate gastric emptying and blood samples were obtained consecutively throughout the study period.RESULTS: We show that oral consumption of D/L-3-OHB stimulates cholecystokinin release (p=0.02), elevates insulin (p=0.03) and C-peptide (p<0.001) concentrations, and slows gastric emptying (p=0.01) compared with intravenous D/L-3-OHB administration. Measures of appetite and plasma concentrations of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were unaffected by interventions.CONCLUSION: Our findings show that D/L-3-OHB exert incretin effects and indicate luminal sensing in the gut endothelium. This adds to our understanding of ketones as signalling metabolites and displays the important difference between physiological ketosis and oral ketone supplements.

U2 - 10.1210/clinem/dgaa483

DO - 10.1210/clinem/dgaa483

M3 - Journal article

C2 - 32717058

VL - 105

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -