Esben Thyssen Vestergaard

Circulating acylghrelin levels are suppressed by insulin and increase in response to hypoglycemia in healthy adult volunteers

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Context: Ghrelin has glucoregulatory and orexigenic actions, but its role in acute hypoglycemia remains uncertain. Objective: To investigate circulating levels of acylghrelin (AG) and unacylated ghrelin (UAG) in response to hyperinsulinemia and to hypoglycemia. Design: A randomized, single blind, placebo controlled crossover study including three study days. Setting: The study was performed at a university hospital clinical research center. Patients and interventions: Nine healthy men completed three study days: I) saline control (CTR), II) hyperinsulinaemic euglycemia (HE) (bolus insulin 0.1 IE/kg i.v. and glucose 20% i.v. for 105 minutes, plasma glucose ≈ 5 m¬mol/l), and III) hyperinsulinaemic hypoglycemia (HH) (bolus insulin 0.1 IE/kg i.v.). Results: HH and HE suppressed AG concentrations at t=45-60 min as compared to CTR (P<0.05). At t=90 min a rebound increase in AG was observed in response to HH as compared to both HE and CTR (P<0.05). UAG also decreased during HH and HE at t=45 min (P<0.05), whereas the AG-to-UAG ratio remained unaffected. Conclusions: This study demonstrates that AG and UAG are directly suppressed by hyperinsulinemia and that AG concentrations increase after a latency of ≈ 1 h in response to hypoglycemia, suggesting a potential counterregulatory role of AG.

Original languageEnglish
JournalEuropean journal of endocrinology / European Federation of Endocrine Societies
Pages (from-to)357-62
Publication statusPublished - 19 Jan 2015

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