Esben Thyssen Vestergaard

Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men. / Vestergaard, Esben Thyssen; Zubanovic, Natasa Brkovic; Rittig, Nikolaj; Moller, Niels; Kuhre, Rune Ehrenreich; Holst, Jens J.; Rehfeld, Jens F.; Thomsen, Henrik Holm.

In: Diabetes, Obesity and Metabolism, Vol. 23, No. 8, 08.2021, p. 1834-1842.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Vestergaard, ET, Zubanovic, NB, Rittig, N, Moller, N, Kuhre, RE, Holst, JJ, Rehfeld, JF & Thomsen, HH 2021, 'Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men', Diabetes, Obesity and Metabolism, vol. 23, no. 8, pp. 1834-1842. https://doi.org/10.1111/dom.14402

APA

CBE

MLA

Vancouver

Author

Vestergaard, Esben Thyssen ; Zubanovic, Natasa Brkovic ; Rittig, Nikolaj ; Moller, Niels ; Kuhre, Rune Ehrenreich ; Holst, Jens J. ; Rehfeld, Jens F. ; Thomsen, Henrik Holm. / Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men. In: Diabetes, Obesity and Metabolism. 2021 ; Vol. 23, No. 8. pp. 1834-1842.

Bibtex

@article{73aae694b1694943a988210a9c60223e,
title = "Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men",
abstract = "Aim: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration. Methods: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 along with appetite sensation scores assessed by visual analogue scale. Results: KE ingestion resulted in an average peak beta-hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were −52.1 (−79.4, –24.8) for KE and −48.4 (−75.4, −21.5) pg/mL for GLU intake (P <.01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP-1, GIP, gastrin and cholecystokinin were not affected by KE ingestion. Conclusion: Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP-1.",
keywords = "appetite control, clinical trial, dietary intervention, GLP-1, randomized trial, WEIGHT-LOSS, INSULIN SENSITIVITY, GLUCOSE, HYDROXYBUTYRATE, CHOLECYSTOKININ, SECRETION, HORMONE, GASTRIN, DIET, Appetite, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Humans, Male, Ketosis, Ghrelin",
author = "Vestergaard, {Esben Thyssen} and Zubanovic, {Natasa Brkovic} and Nikolaj Rittig and Niels Moller and Kuhre, {Rune Ehrenreich} and Holst, {Jens J.} and Rehfeld, {Jens F.} and Thomsen, {Henrik Holm}",
year = "2021",
month = aug,
doi = "10.1111/dom.14402",
language = "English",
volume = "23",
pages = "1834--1842",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

AU - Vestergaard, Esben Thyssen

AU - Zubanovic, Natasa Brkovic

AU - Rittig, Nikolaj

AU - Moller, Niels

AU - Kuhre, Rune Ehrenreich

AU - Holst, Jens J.

AU - Rehfeld, Jens F.

AU - Thomsen, Henrik Holm

PY - 2021/8

Y1 - 2021/8

N2 - Aim: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration. Methods: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 along with appetite sensation scores assessed by visual analogue scale. Results: KE ingestion resulted in an average peak beta-hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were −52.1 (−79.4, –24.8) for KE and −48.4 (−75.4, −21.5) pg/mL for GLU intake (P <.01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP-1, GIP, gastrin and cholecystokinin were not affected by KE ingestion. Conclusion: Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP-1.

AB - Aim: To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG) and glucagon-like peptide-1 (GLP-1) secretion, and to compare responses with those elicited by isocaloric glucose (GLU) administration. Methods: We examined 10 healthy young men on three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric and isocaloric 50% GLU and taste-matched isovolumetric PBO vehicle was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 along with appetite sensation scores assessed by visual analogue scale. Results: KE ingestion resulted in an average peak beta-hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by approximately 25% following both KE and GLU intake compared with PBO. In the case of AG, the differences were −52.1 (−79.4, –24.8) for KE and −48.4 (−75.4, −21.5) pg/mL for GLU intake (P <.01). Concentrations of AG remained lower with KE but returned to baseline and were comparable with PBO levels after GLU intake. GLP-1, GIP, gastrin and cholecystokinin were not affected by KE ingestion. Conclusion: Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonaemia are more probable to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP or GLP-1.

KW - appetite control

KW - clinical trial

KW - dietary intervention

KW - GLP-1

KW - randomized trial

KW - WEIGHT-LOSS

KW - INSULIN SENSITIVITY

KW - GLUCOSE

KW - HYDROXYBUTYRATE

KW - CHOLECYSTOKININ

KW - SECRETION

KW - HORMONE

KW - GASTRIN

KW - DIET

KW - Appetite

KW - Gastric Inhibitory Polypeptide

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Male

KW - Ketosis

KW - Ghrelin

U2 - 10.1111/dom.14402

DO - 10.1111/dom.14402

M3 - Journal article

C2 - 33852195

VL - 23

SP - 1834

EP - 1842

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 8

ER -