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Esben Meldgaard Høgh Quistgaard

Understanding transport by the major facilitator superfamily (MFS): Structures pave the way

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  • Esben M. Quistgaard
  • Christian Löw, European Molecular Biology Laboratory Hamburg
  • ,
  • Fatma Guettou, Karolinska Institutet
  • ,
  • Pär Nordlund, Nanyang Technological University

Members of the major facilitator superfamily (MFS) of transport proteins are essential for the movement of a wide range of substrates across biomembranes. As this transport requires a series of conformational changes, structures of MFS transporters captured in different conformational states are needed to decipher the transport mechanism. Recently, a large number of MFS transporter structures have been determined, which has provided us with an unprecedented opportunity to understand general aspects of the transport mechanism. We propose an updated model for the conformational cycle of MFS transporters, the 'clamp-and-switch model', and discuss the role of so-called 'gating residues' and the substrate in modulating these conformational changes.

Original languageEnglish
JournalNature Reviews. Molecular Cell Biology
Pages (from-to)123-132
Number of pages10
Publication statusPublished - 1 Feb 2016

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