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Esben Meldgaard Høgh Quistgaard

Structural insights into substrate recognition in proton-dependent oligopeptide transporters

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Structural insights into substrate recognition in proton-dependent oligopeptide transporters. / Guettou, Fatma; Quistgaard, Esben M; Trésaugues, Lionel; Moberg, Per; Jegerschöld, Caroline; Zhu, Lin; Jong, Agnes Jin Oi; Nordlund, Pär; Löw, Christian.

In: E M B O Reports, Vol. 14, No. 9, 09.2013, p. 804-10.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Guettou, F, Quistgaard, EM, Trésaugues, L, Moberg, P, Jegerschöld, C, Zhu, L, Jong, AJO, Nordlund, P & Löw, C 2013, 'Structural insights into substrate recognition in proton-dependent oligopeptide transporters', E M B O Reports, vol. 14, no. 9, pp. 804-10. https://doi.org/10.1038/embor.2013.107

APA

Guettou, F., Quistgaard, E. M., Trésaugues, L., Moberg, P., Jegerschöld, C., Zhu, L., Jong, A. J. O., Nordlund, P., & Löw, C. (2013). Structural insights into substrate recognition in proton-dependent oligopeptide transporters. E M B O Reports, 14(9), 804-10. https://doi.org/10.1038/embor.2013.107

CBE

Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJO, Nordlund P, Löw C. 2013. Structural insights into substrate recognition in proton-dependent oligopeptide transporters. E M B O Reports. 14(9):804-10. https://doi.org/10.1038/embor.2013.107

MLA

Vancouver

Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L et al. Structural insights into substrate recognition in proton-dependent oligopeptide transporters. E M B O Reports. 2013 Sep;14(9):804-10. https://doi.org/10.1038/embor.2013.107

Author

Guettou, Fatma ; Quistgaard, Esben M ; Trésaugues, Lionel ; Moberg, Per ; Jegerschöld, Caroline ; Zhu, Lin ; Jong, Agnes Jin Oi ; Nordlund, Pär ; Löw, Christian. / Structural insights into substrate recognition in proton-dependent oligopeptide transporters. In: E M B O Reports. 2013 ; Vol. 14, No. 9. pp. 804-10.

Bibtex

@article{26619824616c40a0a33490d8e2a63460,
title = "Structural insights into substrate recognition in proton-dependent oligopeptide transporters",
abstract = "Short-chain peptides are transported across membranes through promiscuous proton-dependent oligopeptide transporters (POTs)--a subfamily of the major facilitator superfamily (MFS). The human POTs, PEPT1 and PEPT2, are also involved in the absorption of various drugs in the gut as well as transport to target cells. Here, we present a structure of an oligomeric POT transporter from Shewanella oneidensis (PepTSo2), which was crystallized in the inward open conformation in complex with the peptidomimetic alafosfalin. All ligand-binding residues are highly conserved and the structural insights presented here are therefore likely to also apply to human POTs.",
keywords = "Alanine, Amino Acid Sequence, Bacterial Proteins, Molecular Docking Simulation, Molecular Sequence Data, Protein Binding, Shewanella, Symporters, Journal Article",
author = "Fatma Guettou and Quistgaard, {Esben M} and Lionel Tr{\'e}saugues and Per Moberg and Caroline Jegersch{\"o}ld and Lin Zhu and Jong, {Agnes Jin Oi} and P{\"a}r Nordlund and Christian L{\"o}w",
year = "2013",
month = sep,
doi = "10.1038/embor.2013.107",
language = "English",
volume = "14",
pages = "804--10",
journal = "E M B O Reports",
issn = "1469-221X",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Structural insights into substrate recognition in proton-dependent oligopeptide transporters

AU - Guettou, Fatma

AU - Quistgaard, Esben M

AU - Trésaugues, Lionel

AU - Moberg, Per

AU - Jegerschöld, Caroline

AU - Zhu, Lin

AU - Jong, Agnes Jin Oi

AU - Nordlund, Pär

AU - Löw, Christian

PY - 2013/9

Y1 - 2013/9

N2 - Short-chain peptides are transported across membranes through promiscuous proton-dependent oligopeptide transporters (POTs)--a subfamily of the major facilitator superfamily (MFS). The human POTs, PEPT1 and PEPT2, are also involved in the absorption of various drugs in the gut as well as transport to target cells. Here, we present a structure of an oligomeric POT transporter from Shewanella oneidensis (PepTSo2), which was crystallized in the inward open conformation in complex with the peptidomimetic alafosfalin. All ligand-binding residues are highly conserved and the structural insights presented here are therefore likely to also apply to human POTs.

AB - Short-chain peptides are transported across membranes through promiscuous proton-dependent oligopeptide transporters (POTs)--a subfamily of the major facilitator superfamily (MFS). The human POTs, PEPT1 and PEPT2, are also involved in the absorption of various drugs in the gut as well as transport to target cells. Here, we present a structure of an oligomeric POT transporter from Shewanella oneidensis (PepTSo2), which was crystallized in the inward open conformation in complex with the peptidomimetic alafosfalin. All ligand-binding residues are highly conserved and the structural insights presented here are therefore likely to also apply to human POTs.

KW - Alanine

KW - Amino Acid Sequence

KW - Bacterial Proteins

KW - Molecular Docking Simulation

KW - Molecular Sequence Data

KW - Protein Binding

KW - Shewanella

KW - Symporters

KW - Journal Article

U2 - 10.1038/embor.2013.107

DO - 10.1038/embor.2013.107

M3 - Journal article

C2 - 23867627

VL - 14

SP - 804

EP - 810

JO - E M B O Reports

JF - E M B O Reports

SN - 1469-221X

IS - 9

ER -