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Esben Meldgaard Høgh Quistgaard

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

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DOI

Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein.

Original languageEnglish
JournalNature Structural and Molecular Biology
Volume20
Issue6
Pages (from-to)766-8
Number of pages3
ISSN1545-9993
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

    Research areas

  • Crystallography, X-Ray, Escherichia coli, Escherichia coli Proteins, Models, Molecular, Protein Conformation, Symporters, Journal Article, Research Support, Non-U.S. Gov't

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