Ermelinda Porpiglia

Tenure Track Assistant Professor

Ermelinda Porpiglia

Tenure Track Assistant Professor

  • Department of Biomedicine - Forskning og uddannelse, Skou-bygningen
Postal address:
Høegh-Guldbergs Gade 10
1115, 132
8000
Aarhus C
Denmark

Email: eporpiglia@biomed.au.dk

Qualifications

Biomedical Sciences, PhD, University of Massachusetts Worcester

1 Sep 200431 Aug 2011

Award Date: 31 Aug 2011

Stem Cell Biology and Regenerative Medicine, Postdoctoral Training, Stanford University

15 Sep 20111 Sep 2016

Research outputs

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Frimand, Z., Das Barman, S., Kjær, T. R., Porpiglia, E. & de Morree, A., 9 Dec 2022, In: Journal of Visualized Experiments. 190, p. e64557

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Porpiglia, E., Mai, T., Kraft, P., Holbrook, C. A., de Morree, A., Gonzalez, V. D., Hilgendorf, K. I., Frésard, L., Trejo, A., Bhimaraju, S., Jackson, P. K., Fantl, W. J. & Blau, H. M., 1 Dec 2022, In: Cell Stem Cell. 29, 12, p. 1653-1668.e8 16 p.

Plasticity of muscle stem cells in homeostasis and aging

Porpiglia, E. & Blau, H. M., Dec 2022, In: Current Opinion in Genetics & Development. 77

Measuring trogocytosis between ovarian tumor and natural killer cells

Delgado-Gonzalez, A., Huang, Y-W., Porpiglia, E., Donoso, K., Gonzalez, V. D. & Fantl, W. J., 17 Jun 2022, In: STAR Protocols. 3, 2, 101425.

Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevance

Danielli, S., Porpiglia, E. & Schafer, B., 20 Apr 2022, bioRxiv.

High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Gonzalez, V. D., Huang, Y-W., Delgado-Gonzalez, A., Chen, S-Y., Donoso, K., Sachs, K., Gentles, A. J., Allard, G. M., Kolahi, K. S., Howitt, B. E., Porpiglia, E. & Fantl, W. J., 31 Aug 2021, In: Cell Reports. 36, 9, p. 109632

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Yucel, N., Wang, Y. X., Mai, T., Porpiglia, E., Lund, P. J., Markov, G., Garcia, B. A., Bendall, S. C., Angelo, M. & Blau, H. M., 25 Jun 2019, In: Cell Reports. 27, 13, p. 3939-3955.e6

High-resolution myogenic lineage mapping by single-cell mass cytometry

Porpiglia, E., Samusik, N., Ho, A. T. V., Cosgrove, B. D., Mai, T., Davis, K. L., Jager, A., Nolan, G. P., Bendall, S. C., Fantl, W. J. & Blau, H. M., May 2017, In: Nature Cell Biology. 19, 5, p. 558-567 10 p.

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L. & Blau, H. M., Mar 2014, In: Nature Medicine. 20, 3, p. 255-64 10 p.

Erythropoiesis: from molecular pathways to system properties

Koulnis, M., Porpiglia, E., Hidalgo, D. & Socolovsky, M., 2014, In: Advances in Experimental Medicine and Biology. 844, p. 37-58 22 p.

Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities

Porpiglia, E., Hidalgo, D., Koulnis, M., Tzafriri, A. R. & Socolovsky, M., Aug 2012, In: PLoS Biology. 10, 8, p. e1001383

Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways

Koulnis, M., Porpiglia, E., Porpiglia, P. A., Liu, Y., Hallstrom, K., Hidalgo, D. & Socolovsky, M., 2 Feb 2012, In: Blood. 119, 5, p. 1228-39 12 p.

Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay

Koulnis, M., Pop, R., Porpiglia, E., Shearstone, J. R., Hidalgo, D. & Socolovsky, M., 5 Aug 2011, In: Journal of visualized experiments : JoVE. 54

Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

Flatt, T., Heyland, A., Rus, F., Porpiglia, E., Sherlock, C., Yamamoto, R., Garbuzov, A., Palli, S. R., Tatar, M. & Silverman, N., Aug 2008, In: The Journal of Experimental Biology. 211, Pt 16, p. 2712-24 13 p.

Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses

Zhou, S., Halle, A., Kurt-Jones, E. A., Cerny, A. M., Porpiglia, E., Rogers, M., Golenbock, D. T. & Finberg, R. W., Feb 2008, In: Journal of Neuroimmunology. 194, 1-2, p. 70-82 13 p.

Negative autoregulation by FAS mediates robust fetal erythropoiesis

Socolovsky, M., Murrell, M., Liu, Y., Pop, R., Porpiglia, E. & Levchenko, A., Oct 2007, In: PLoS Biology. 5, 10, p. e252

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons

MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J. & Freeman, M. R., 15 Jun 2006, In: Neuron. 50, 6, p. 869-81 13 p.

Activities

Danish Diabetes Academy Postdoc Summit

Ermelinda Porpiglia (Invited speaker)

25 Sep 202230 Sep 2022

Aging Muscle Symposium

Ermelinda Porpiglia (Invited speaker)

16 Sep 202217 Sep 2022

The Skeletal Muscle Stem Cells and Regeneration Conference

Ermelinda Porpiglia (Participant)

24 Jul 202229 Jul 2022

Multiplexed Imaging and Single-cell Profiling of Cellular Metabolism

Ermelinda Porpiglia (Chair person)

11 May 2022

German Mass Cytometry User Forum

Ermelinda Porpiglia (Participant)

20 Jan 202221 Jan 2022

Global Healing (External organisation)

Ermelinda Porpiglia (Member)

2022

Muscular Dystrophy UK (External organisation)

Ermelinda Porpiglia (Member)

2022

International Society for Advancement of Cytometry (External organisation)

Ermelinda Porpiglia (Member)

2021

MIT-Press (Journal)

Ermelinda Porpiglia (Reviewer)

2020

Stanford Women on Boards (External organisation)

Ermelinda Porpiglia (Member)

2020

Awards

Aarhus Institute for Advanced Studies

Porpiglia, E.

Aarhus Institute for Advanced Studies, Aarhus University

01/08/202231/07/2024

Award date: 30/06/2022

NNF Start Package Grant

Porpiglia, E.

Novo Nordisk Foundation: DKK3,000,000.00

01/08/202131/07/2025

Award date: 01/09/2021

AUFF Assistant Professor Starting Grant

Porpiglia, E.

AUFF, Aarhus University Research Foundation: DKK2,600,000.00

01/08/202131/07/2024

Award date: 01/08/2021

Projects

Mapping niche dynamics at single-cell resolution to boost the regenerative potential of aged skeletal muscle

Porpiglia, E.

01/01/202231/12/2025

Teaching and Supervision

Empirical Bachelor Project

Ermelinda Porpiglia

31/01/202231/05/2022