Ermelinda Porpiglia
Tenure Track Assistant Professor
Department of Biomedicine - Forskning og uddannelse, Skou-bygningen
Høegh-Guldbergs Gade 10
building 1115, 132
8000 Aarhus C
Denmark
Research areas
Profile
Dr. Porpiglia is a tenure-track Assistant Professor in the Department of Biomedicine and an Associate Fellow at the Aarhus Institute of Advanced Studies (AIAS).
Effective regeneration, in skeletal muscle as well as in many other tissues, depends on the coordinated and timely interaction of stromal cells, immune cells and stem cells. The Porpiglia lab employs novel single-cell technologies, such as single-cell mass cytometry (CyTOF), to study the relationships between muscle stem cells and immune cells in aged and dystrophic skeletal muscle. Specifically, our research focuses on understanding how unique interactions between immune cells and muscle stem cells orchestrates effective muscle regeneration and on identifying the cellular interactions and signaling pathways that are impaired during ineffective muscle regeneration, in aging and muscular dystrophies. This research will help us develop strategies to modulate the immune system to boost muscle tissue repair.
- Published
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
Porpiglia, E., Mai, T., Kraft, P., Holbrook, C. A., de Morree, A., Gonzalez, V. D., Hilgendorf, K. I., Frésard, L., Trejo, A., Bhimaraju, S., Jackson, P. K., Fantl, W. J. & Blau, H. M., 1 Dec 2022, In: Cell Stem Cell. 29, 12, p. 1653-1668.e8 16 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
- Published
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L. & Blau, H. M., Mar 2014, In: Nature Medicine. 20, 3, p. 255-64 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
- Published
High-resolution myogenic lineage mapping by single-cell mass cytometry
Porpiglia, E., Samusik, N., Ho, A. T. V., Cosgrove, B. D., Mai, T., Davis, K. L., Jager, A., Nolan, G. P., Bendall, S. C., Fantl, W. J. & Blau, H. M., May 2017, In: Nature Cell Biology. 19, 5, p. 558-567 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
CellX Meeting on Single Cell and Spatial OMICS 2023
Activity: Participating in or organising an event types › Participation in or organisation af a conference
Mapping niche dynamics at single-cell resolution in skeletal muscle using mass cytometry
Activity: Talk or presentation types › Lecture and oral contribution
Scientific Tutorial - Perspectives on transitioning between mass and flow cytometry
Activity: Participating in or organising an event types › Participation in or organisation of workshop, seminar or course
NNF Start Package Grant
Prize: Prizes, scholarships, distinctions
AUFF Assistant Professor Starting Grant
Prize: Prizes, scholarships, distinctions
AIAS Associate Fellow
Prize: Prizes, scholarships, distinctions
Study unlocks potential new treatment strategy for aggressive childhood cancer
Press/Media: Press / Media
New study: Blocking protein may improve the body’s ability to repair muscle damage as we age
Press/Media: Press / Media
New study: Blocking protein can improve the body's ability to repair muscle damage
Press/Media: Press / Media
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