Erik Ernst

Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Claus Yding Andersen, Denmark
  • Mikkel Rosendahl, Denmark
  • Anne Grete Byskov, Denmark
  • Anne Loft, Denmark
  • Christian Ottosen, Denmark
  • Margit Dueholm
  • Kirsten L T Schmidt, Denmark
  • Anders Nyboe Andersen, Denmark
  • Erik Ernst
  • Department of Anatomy
  • Obstetrics and Gynaecology
BACKGROUND: Cryopreservation of the ovarian cortex with subsequent autotransplantation has, on an experimental basis, been performed to preserve fertility in women being treated for a malignant disease. The present study reports ovarian activity and pregnancies following autotransplantation of frozen/thawed ovarian tissue. METHODS: One complete ovary was cryopreserved from each of six patients who were 26-35 years old prior to treatment. Tissue from three of the patients was transported 4-5 h on ice prior to cryopreservation. After a period of 17-32 months, orthotopic autotransplantation was performed replacing 20-60% of the tissue. Two patients received additional heterotopic transplants. RESULTS: In all cases, the tissue restored menstrual cyclicity 14-20 weeks following transplantation. Four of the six women conceived following assisted reproduction: two women (who had the tissue transported 4-5 h prior to cryopreservation) each, based on the orthotopic transplanted tissue, delivered one healthy child (February 2007 and January 2008); one woman miscarriaged in gestational Week 7; and the other had a positive hCG test but no clinical pregnancy. The remaining two women did not become pregnant. CONCLUSIONS: Two additional healthy children have been born as a result of the ovarian cryopreservation procedure. In both cases, the ovarian tissue was transported 4-5 h prior to freezing demonstrating that hospitals may offer cryopreservation without having the necessary expertise locally.
Original languageEnglish
JournalHuman Reproduction
Pages (from-to)2266-72
Number of pages6
Publication statusPublished - 2008

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