Erik Ernst

Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • S E Gellert, Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Faculty of Health and Medicine, University of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100, Copenhagen, Denmark.
  • ,
  • S E Pors, Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Faculty of Health and Medicine, University of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100, Copenhagen, Denmark.
  • ,
  • Stine Gry Kristensen, Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Faculty of Health and Medicine, University of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100, Copenhagen, Denmark., University of Copenhagen, Denmark
  • A M Bay-Bjørn
  • ,
  • E Ernst
  • C Yding Andersen, Laboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Faculty of Health and Medicine, University of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100, Copenhagen, Denmark. yding@rh.dk.

PURPOSE: The purpose of the study is to review all peer-reviewed published reports of women receiving ovarian tissue transplantation (OTT) with frozen/thawed tissue (OTC) with respect to age, diagnosis, transplantation site, fertility outcome, and potential side effects, including data from all women in the Danish program.

METHODS: A systematic review of the literature was performed in PubMed combined with results from all patients who had received OTT in Denmark up to December 2017.

RESULTS: OTT has been reported from 21 different countries comprising a total of 360 OTT procedures in 318 women. In nine women, malignancy was diagnosed after OTT; none were considered to be directly caused by the OTT. Despite a potential under reporting of cancer recurrence, there is currently no evidence to suggest that OTT causes reseeding of the original cancer. Renewed ovarian endocrine function was reported in 95% of the women. Half of all children born following OTT resulted from natural conception, and newborns were reported to be healthy except for one neonate with a chromosome anomaly with a family disposition. Women who conceived after OTT were significantly younger than those who failed.

CONCLUSION: This study found no indications of sufficient numbers of malignant cells present in the ovarian tissue to cause recurrence of cancer after OTT. Further, it is unlikely that OTC affects the well-being of children born. OTC is now an established method of fertility preservation in Denmark with public reimbursement. The current data encourage that women who require gonadotoxic treatment should be offered an individual evaluation considering fertility preservation.

Original languageEnglish
JournalJournal of Assisted Reproduction and Genetics
Volume35
Issue4
Pages (from-to)561-570
Number of pages10
ISSN1058-0468
DOIs
Publication statusPublished - Apr 2018

    Research areas

  • Cohort Studies, Cryopreservation, Denmark, Female, Fertility Preservation, Humans, Meta-Analysis as Topic, Ovary/transplantation, Pregnancy, Pregnancy Outcome, Primary Ovarian Insufficiency/therapy, Transplantation, Autologous

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