Erik Ernst

Successful pregnancy in a woman previously suffering from β-thalassemia following transplantation of ovarian tissue cryopreserved before puberty

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Sara J Matthews, Laboratory of Reproductive Biology, Juliane Marie Centre, Section 5712, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  • ,
  • Helen M Picton, The Division of Reproduction and Early Development, School of Medicine, University of Leeds, Leeds, UK.
  • ,
  • Erik Ernst
  • Claus Y Andersen, Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Ovarian tissue removed from a nine year old girl suffering from thalassemia was kept deep- frozen for 14 years before being transplanted back to the now adult woman. Subsequently, she conceived following IVF treatment and delivered a healthy baby where the oocyte derived from the transplanted tissue. This is the first woman worldwide to have a baby where the ovarian tissue was frozen pre-pubertally and expand the therapeutic options for rare genetic diseases like thalassemia and girls who suffer from childhood cancer.

Original languageEnglish
JournalMinerva Ginecologica
Pages (from-to)432-435
Number of pages4
Publication statusPublished - Aug 2018

    Research areas

  • Fertility preservation, Freezing, Ovary, Thalassemia, Transplantation

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