Erik Ernst

Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood

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Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood. / Kristensen, Susanne Lund; Ramlau-Hansen, Cecilia Høst; Ernst, Erik; Olsen, Sjurdur Frodi; Bonde, Jens Peter; Vested, Anne; Halldorsson, Thorhallur Ingi; Rantakokko, Panu; Kiviranta, Hannu; Toft, Gunnar.

In: Environment International, Vol. 92-93, 02.05.2016, p. 366-72.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Kristensen, SL, Ramlau-Hansen, CH, Ernst, E, Olsen, SF, Bonde, JP, Vested, A, Halldorsson, TI, Rantakokko, P, Kiviranta, H & Toft, G 2016, 'Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood', Environment International, vol. 92-93, pp. 366-72. https://doi.org/10.1016/j.envint.2016.04.024

APA

Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Rantakokko, P., Kiviranta, H., & Toft, G. (2016). Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood. Environment International, 92-93, 366-72. https://doi.org/10.1016/j.envint.2016.04.024

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MLA

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Author

Kristensen, Susanne Lund ; Ramlau-Hansen, Cecilia Høst ; Ernst, Erik ; Olsen, Sjurdur Frodi ; Bonde, Jens Peter ; Vested, Anne ; Halldorsson, Thorhallur Ingi ; Rantakokko, Panu ; Kiviranta, Hannu ; Toft, Gunnar. / Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood. In: Environment International. 2016 ; Vol. 92-93. pp. 366-72.

Bibtex

@article{68915b229d374af18815c3d969419497,
title = "Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood",
abstract = "BACKGROUND: The biopersistent organochlorine pollutants dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) can be detected in humans worldwide. The chemicals can cross the placenta and may interfere with endogenous hormonal homeostasis.OBJECTIVES: To investigate effects on female reproduction following intrauterine exposure to selected biopersistent organochlorines.METHODS: We used data from a Danish pregnancy cohort with follow-up on 436 eligible daughters at approximately 20years of age. Information on age of menarche (n=335), menstrual cycle length (n=230) and serum concentrations of reproductive hormones (n=243) was obtained. Number of antral follicles was counted by vaginal ultrasound (n=147). Of 244 daughters who attended clinical examination, 170 used hormonal contraceptives and 74 were non-users. Concentrations of p,p'-DDE, HCB and six PCB congeners were analysed in maternal serum samples obtained in pregnancy week 30.RESULTS: Age of menarche and menstrual cycle length were found not to be statistically significant associated with prenatal organochlorine exposure. Among non-users of hormonal contraceptives with information on antral follicle number (n=43), daughters exposed to the highest tertile of p,p'-DDE had 28% (95% confidence interval (95% CI): 5; 46%) lower follicle number compared to the low-level exposed reference group. Those exposed to medium and higher levels of HCB had 30% (95% CI: 5; 48%) and 28% (95% CI: 7; 44%) lower follicle number compared to the reference group. Furthermore, maternal serum HCB concentrations were inversely associated with free androgen index among non-users of hormonal contraceptives (n=73). These associations were not found in users of hormonal contraceptives.CONCLUSIONS: Among non-users of hormonal contraceptives, we found indications of adverse long-term effects on female reproduction following prenatal exposure to biopersistent organochlorines. These findings may have wide implications for public health as intrauterine exposure occurs worldwide.",
author = "Kristensen, {Susanne Lund} and Ramlau-Hansen, {Cecilia H{\o}st} and Erik Ernst and Olsen, {Sjurdur Frodi} and Bonde, {Jens Peter} and Anne Vested and Halldorsson, {Thorhallur Ingi} and Panu Rantakokko and Hannu Kiviranta and Gunnar Toft",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = may,
day = "2",
doi = "10.1016/j.envint.2016.04.024",
language = "English",
volume = "92-93",
pages = "366--72",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood

AU - Kristensen, Susanne Lund

AU - Ramlau-Hansen, Cecilia Høst

AU - Ernst, Erik

AU - Olsen, Sjurdur Frodi

AU - Bonde, Jens Peter

AU - Vested, Anne

AU - Halldorsson, Thorhallur Ingi

AU - Rantakokko, Panu

AU - Kiviranta, Hannu

AU - Toft, Gunnar

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/5/2

Y1 - 2016/5/2

N2 - BACKGROUND: The biopersistent organochlorine pollutants dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) can be detected in humans worldwide. The chemicals can cross the placenta and may interfere with endogenous hormonal homeostasis.OBJECTIVES: To investigate effects on female reproduction following intrauterine exposure to selected biopersistent organochlorines.METHODS: We used data from a Danish pregnancy cohort with follow-up on 436 eligible daughters at approximately 20years of age. Information on age of menarche (n=335), menstrual cycle length (n=230) and serum concentrations of reproductive hormones (n=243) was obtained. Number of antral follicles was counted by vaginal ultrasound (n=147). Of 244 daughters who attended clinical examination, 170 used hormonal contraceptives and 74 were non-users. Concentrations of p,p'-DDE, HCB and six PCB congeners were analysed in maternal serum samples obtained in pregnancy week 30.RESULTS: Age of menarche and menstrual cycle length were found not to be statistically significant associated with prenatal organochlorine exposure. Among non-users of hormonal contraceptives with information on antral follicle number (n=43), daughters exposed to the highest tertile of p,p'-DDE had 28% (95% confidence interval (95% CI): 5; 46%) lower follicle number compared to the low-level exposed reference group. Those exposed to medium and higher levels of HCB had 30% (95% CI: 5; 48%) and 28% (95% CI: 7; 44%) lower follicle number compared to the reference group. Furthermore, maternal serum HCB concentrations were inversely associated with free androgen index among non-users of hormonal contraceptives (n=73). These associations were not found in users of hormonal contraceptives.CONCLUSIONS: Among non-users of hormonal contraceptives, we found indications of adverse long-term effects on female reproduction following prenatal exposure to biopersistent organochlorines. These findings may have wide implications for public health as intrauterine exposure occurs worldwide.

AB - BACKGROUND: The biopersistent organochlorine pollutants dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) can be detected in humans worldwide. The chemicals can cross the placenta and may interfere with endogenous hormonal homeostasis.OBJECTIVES: To investigate effects on female reproduction following intrauterine exposure to selected biopersistent organochlorines.METHODS: We used data from a Danish pregnancy cohort with follow-up on 436 eligible daughters at approximately 20years of age. Information on age of menarche (n=335), menstrual cycle length (n=230) and serum concentrations of reproductive hormones (n=243) was obtained. Number of antral follicles was counted by vaginal ultrasound (n=147). Of 244 daughters who attended clinical examination, 170 used hormonal contraceptives and 74 were non-users. Concentrations of p,p'-DDE, HCB and six PCB congeners were analysed in maternal serum samples obtained in pregnancy week 30.RESULTS: Age of menarche and menstrual cycle length were found not to be statistically significant associated with prenatal organochlorine exposure. Among non-users of hormonal contraceptives with information on antral follicle number (n=43), daughters exposed to the highest tertile of p,p'-DDE had 28% (95% confidence interval (95% CI): 5; 46%) lower follicle number compared to the low-level exposed reference group. Those exposed to medium and higher levels of HCB had 30% (95% CI: 5; 48%) and 28% (95% CI: 7; 44%) lower follicle number compared to the reference group. Furthermore, maternal serum HCB concentrations were inversely associated with free androgen index among non-users of hormonal contraceptives (n=73). These associations were not found in users of hormonal contraceptives.CONCLUSIONS: Among non-users of hormonal contraceptives, we found indications of adverse long-term effects on female reproduction following prenatal exposure to biopersistent organochlorines. These findings may have wide implications for public health as intrauterine exposure occurs worldwide.

U2 - 10.1016/j.envint.2016.04.024

DO - 10.1016/j.envint.2016.04.024

M3 - Journal article

C2 - 27132162

VL - 92-93

SP - 366

EP - 372

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -