Erik Ernst

Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Signe Taasti Andersen, Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Susanne Elisabeth Pors, Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Liv la Cour Poulsen, The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark.
  • ,
  • Lotte Berdiin Colmorn, The Fertility Clinic, The Juliane Marie Centre, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
  • ,
  • Kirsten Tryde Macklon, The Fertility Clinic, The Juliane Marie Centre, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
  • ,
  • Erik Ernst
  • Peter Humaidan
  • Claus Yding Andersen, Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Stine Gry Kristensen, Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark. Electronic address: stine.gry.kristensen@regionh.dk.

OBJECTIVE: To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue.

DESIGN: Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

SETTING: Not applicable.

PATIENT(S): Women undergoing ovarian tissue transplantation (OTT) and subsequent ART.

INTERVENTION(S): Literature search in PubMed and Scopus databases.

MAIN OUTCOME MEASURE(S): Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures.

RESULT(S): Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment.

CONCLUSION(S): The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.

Original languageEnglish
JournalFertility and Sterility
Volume112
Issue5
Pages (from-to)908-921
Number of pages14
ISSN0015-0282
DOIs
Publication statusPublished - 2019

    Research areas

  • ART, autotransplantation, live-birth rate, ovarian stimulation, ovarian tissue cryopreservation

See relations at Aarhus University Citationformats

ID: 169180504