Erik Ernst

Long-term duration of function of ovarian tissue transplants: case reports

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Claus Yding Andersen
  • ,
  • Sherman J Silber
  • ,
  • Stinne Holm Berghold
  • ,
  • Jan Stener Jorgensen
  • ,
  • Erik Ernst
These three case reports describe the long-term duration of function of ovarian cortical tissue grafts among patients in a university fertility preservation programme in Europe and in a private practice programme in the USA. One woman underwent sterilizing cancer treatment and had frozen ovarian tissue transplanted, and two women underwent fresh ovarian tissue transplants. The function of ovarian cortical strips has continued for more than 7 years in these three women, with the birth of eight healthy babies following a single graft per patient. In addition to these three cases, transplantation (repeatedly in some cases) of cryopreserved ovarian tissue has restored reproductive function to all other women in the study centres' programmes for some years. The sustained longevity of function of the transplanted tissue suggests that it may also be possible to postpone the normal time of menopause or to alleviate its symptoms.
Original languageEnglish
JournalRBM Online
Volume25
Issue2
Pages (from-to)128-32
Number of pages5
ISSN1472-6491
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Cryopreservation, Female, Fertility Preservation, Humans, Ovary, Pregnancy, Pregnancy Outcome

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