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Erik Baatrup

Ultrastructural localization of silver in rat testis and organ distribution of radioactive silver in the rat.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Interdisciplinary Nanoscience Center
  • Department of Pharmacology
  • Obstetrics and Gynaecology
  • Department of Biological Sciences, Zoophysiology
The deposition of silver after a single intravenous injection (2 micrograms Ag g-1 body weight) was studied in the testes of Wistar rats 24 h and 1 and 2 weeks after dosing with radiolabelled 110AgNo3 (2 micrograms Ag and 1.2 kBq g-1 body weight). Also, the temporal accumulation of silver during the experimental period was monitored in the blood, testes, epididymides, kidney, liver and brain. The subcellular distribution of silver within the testes was demonstrated by using the histochemical technique of autometallography. Silver was cleared rapidly from the blood. After an initial rise, concentrations in organs remained almost stable throughout the experimental period. Silver was especially abundant in interstitial macrophages and in the basement membrane. Deposits of silver were found in all cell types of spermatogenesis and in the lysosomes of the Sertoli cells.
Udgivelsesdato: 1991-Oct
Original languageEnglish
JournalJournal of Applied Toxicology
Volume11
Issue5
Pages (from-to)317-21
Number of pages4
ISSN0260-437X
Publication statusPublished - 1992

    Research areas

  • Animals, Injections, Intravenous, Male, Microscopy, Microscopy, Electron, Radioisotopes, Rats, Rats, Inbred Strains, Silver, Silver Nitrate, Testis, Tissue Distribution

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