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Erik Baatrup

Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice

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Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice. / Iversen, N.K.; Frische, S.; Thomsen, Karen; Laustsen, C.; Pedersen, Michael; Hansen, P.B.L.; Bie, P.; Fresnais, J.; Berret, J.-F.; Baatrup, E.; Wang, T.

In: Toxicology and Applied Pharmacology, Vol. 266, No. 2, 15.01.2013, p. 276-88.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Iversen, N.K. ; Frische, S. ; Thomsen, Karen ; Laustsen, C. ; Pedersen, Michael ; Hansen, P.B.L. ; Bie, P. ; Fresnais, J. ; Berret, J.-F. ; Baatrup, E. ; Wang, T. / Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice. In: Toxicology and Applied Pharmacology. 2013 ; Vol. 266, No. 2. pp. 276-88.

Bibtex

@article{9c4be64a51204e63b500cd10b1d24b1f,
title = "Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice",
abstract = "This study describes the distribution of intravenously injected polyacrylic acid (PAA) coated γ-FeO NPs (10mgkg) at the organ, cellular and subcellular levels in healthy BALB/cJ mice and in parallel addresses the effects of NP injection on kidney function, blood pressure and vascular contractility. Magnetic resonance imaging (MRI) and transmission electron microscopy (TEM) showed accumulation of NPs in the liver within 1h after intravenous infusion, accommodated by intracellular uptake in endothelial and Kupffer cells with subsequent intracellular uptake in renal cells, particularly the cytoplasm of the proximal tubule, in podocytes and mesangial cells. The renofunctional effects of NPs were evaluated by arterial acid-base status and measurements of glomerular filtration rate (GFR) after instrumentation with chronically indwelling catheters. Arterial pH was 7.46±0.02 and 7.41±0.02 in mice 0.5h after injections of saline or NP, and did not change over the next 12h. In addition, the injections of NP did not affect arterial PCO or [HCO] either. Twenty-four and 96h after NP injections, the GFR averaged 0.35±0.04 and 0.35±0.01mlming, respectively, values which were statistically comparable with controls (0.29±0.02 and 0.33±0.1ml min 25g). Mean arterial blood pressure (MAP) decreased 12-24h after NP injections (111.1±11.5 vs 123.0±6.1min) associated with a decreased contractility of small mesenteric arteries revealed by myography to characterize endothelial function. In conclusion, our study demonstrates that accumulation of superparamagnetic iron oxide nanoparticles does not affect kidney function in healthy mice but temporarily decreases blood pressure.",
keywords = "Acrylic Resins, Animals, Blood Pressure, Female, Ferric Compounds, Glomerular Filtration Rate, Hydrogen-Ion Concentration, Injections, Intravenous, Kidney, Magnetic Resonance Imaging, Magnetite Nanoparticles, Male, Mesenteric Arteries, Mice, Mice, Inbred BALB C, Microscopy, Electron, Transmission, Muscle Contraction, Myography, Time Factors, Tissue Distribution",
author = "N.K. Iversen and S. Frische and Karen Thomsen and C. Laustsen and Michael Pedersen and P.B.L. Hansen and P. Bie and J. Fresnais and J.-F. Berret and E. Baatrup and T. Wang",
note = "Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.",
year = "2013",
month = jan,
day = "15",
doi = "10.1016/j.taap.2012.10.014",
language = "English",
volume = "266",
pages = "276--88",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press",
number = "2",

}

RIS

TY - JOUR

T1 - Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice

AU - Iversen, N.K.

AU - Frische, S.

AU - Thomsen, Karen

AU - Laustsen, C.

AU - Pedersen, Michael

AU - Hansen, P.B.L.

AU - Bie, P.

AU - Fresnais, J.

AU - Berret, J.-F.

AU - Baatrup, E.

AU - Wang, T.

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2013/1/15

Y1 - 2013/1/15

N2 - This study describes the distribution of intravenously injected polyacrylic acid (PAA) coated γ-FeO NPs (10mgkg) at the organ, cellular and subcellular levels in healthy BALB/cJ mice and in parallel addresses the effects of NP injection on kidney function, blood pressure and vascular contractility. Magnetic resonance imaging (MRI) and transmission electron microscopy (TEM) showed accumulation of NPs in the liver within 1h after intravenous infusion, accommodated by intracellular uptake in endothelial and Kupffer cells with subsequent intracellular uptake in renal cells, particularly the cytoplasm of the proximal tubule, in podocytes and mesangial cells. The renofunctional effects of NPs were evaluated by arterial acid-base status and measurements of glomerular filtration rate (GFR) after instrumentation with chronically indwelling catheters. Arterial pH was 7.46±0.02 and 7.41±0.02 in mice 0.5h after injections of saline or NP, and did not change over the next 12h. In addition, the injections of NP did not affect arterial PCO or [HCO] either. Twenty-four and 96h after NP injections, the GFR averaged 0.35±0.04 and 0.35±0.01mlming, respectively, values which were statistically comparable with controls (0.29±0.02 and 0.33±0.1ml min 25g). Mean arterial blood pressure (MAP) decreased 12-24h after NP injections (111.1±11.5 vs 123.0±6.1min) associated with a decreased contractility of small mesenteric arteries revealed by myography to characterize endothelial function. In conclusion, our study demonstrates that accumulation of superparamagnetic iron oxide nanoparticles does not affect kidney function in healthy mice but temporarily decreases blood pressure.

AB - This study describes the distribution of intravenously injected polyacrylic acid (PAA) coated γ-FeO NPs (10mgkg) at the organ, cellular and subcellular levels in healthy BALB/cJ mice and in parallel addresses the effects of NP injection on kidney function, blood pressure and vascular contractility. Magnetic resonance imaging (MRI) and transmission electron microscopy (TEM) showed accumulation of NPs in the liver within 1h after intravenous infusion, accommodated by intracellular uptake in endothelial and Kupffer cells with subsequent intracellular uptake in renal cells, particularly the cytoplasm of the proximal tubule, in podocytes and mesangial cells. The renofunctional effects of NPs were evaluated by arterial acid-base status and measurements of glomerular filtration rate (GFR) after instrumentation with chronically indwelling catheters. Arterial pH was 7.46±0.02 and 7.41±0.02 in mice 0.5h after injections of saline or NP, and did not change over the next 12h. In addition, the injections of NP did not affect arterial PCO or [HCO] either. Twenty-four and 96h after NP injections, the GFR averaged 0.35±0.04 and 0.35±0.01mlming, respectively, values which were statistically comparable with controls (0.29±0.02 and 0.33±0.1ml min 25g). Mean arterial blood pressure (MAP) decreased 12-24h after NP injections (111.1±11.5 vs 123.0±6.1min) associated with a decreased contractility of small mesenteric arteries revealed by myography to characterize endothelial function. In conclusion, our study demonstrates that accumulation of superparamagnetic iron oxide nanoparticles does not affect kidney function in healthy mice but temporarily decreases blood pressure.

KW - Acrylic Resins

KW - Animals

KW - Blood Pressure

KW - Female

KW - Ferric Compounds

KW - Glomerular Filtration Rate

KW - Hydrogen-Ion Concentration

KW - Injections, Intravenous

KW - Kidney

KW - Magnetic Resonance Imaging

KW - Magnetite Nanoparticles

KW - Male

KW - Mesenteric Arteries

KW - Mice

KW - Mice, Inbred BALB C

KW - Microscopy, Electron, Transmission

KW - Muscle Contraction

KW - Myography

KW - Time Factors

KW - Tissue Distribution

UR - http://www.scopus.com/inward/record.url?scp=84871839579&partnerID=8YFLogxK

U2 - 10.1016/j.taap.2012.10.014

DO - 10.1016/j.taap.2012.10.014

M3 - Journal article

C2 - 23142473

AN - SCOPUS:84871839579

VL - 266

SP - 276

EP - 288

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -