Elisabeth Bendstrup

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Simon L. F. Walsh, Kings Coll Hosp Fdn Trust, King's College Hospital, King's College Hospital NHS Foundation Trust, Dept Radiol
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  • Toby M. Maher, Imperial Coll London, Imperial College London, Natl Heart & Lung Inst, CF & Chron Lung Infect
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  • Martin Kolb, McMaster Univ, McMaster University, Firestone Inst Resp Hlth, Dept Pathol Mol Med
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  • Venerino Poletti, Osped GB Morgagni, Dept Dis Thorax
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  • Richard Nusser, Summit Hosp, Dept Resp Med
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  • Luca Richeldi, Univ Cattolica Sacro Cuore, Catholic University of the Sacred Heart, Fdn Policlin A Gemelli, Unita Operat Complessa Pneumol
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  • Carlo Vancheri, Univ Catania, University of Catania, Univ Hosp Policlin Vitt Emanuele, Dept Clin & Expt Med
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  • Margaret L. Wilsher, Univ Auckland, University of Auckland, Dept Phys
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  • Katerina M. Antoniou, Univ Crete, University of Crete, Dept Resp Med, Fac Med
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  • Juergen Behr, German Ctr Lung Res, Asklepios Fachkliniken Gauting, Comprehens Pneumol Ctr
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  • Elisabeth Bendstrup
  • Kevin Brown, Natl Jewish Hlth, National Jewish Health
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  • Lucio Calandriello, Univ Cattolica Sacro Cuore, Catholic University of the Sacred Heart, Fdn Policlin Univ A Gemelli, Inst Radiol
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  • Tamera J. Corte, Univ Western Sydney, Western Sydney University
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  • Vincent Cottin, Hop L Pradel, CHU Lyon, Serv Pneumol
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  • Bruno Crestani, Univ Paris Diderot, Sorbonne Universite, Pierre & Marie Curie University - Paris VI, University of Paris Diderot - Paris VII, Universite Sorbonne Paris Cite-USPC (ComUE), Assistance Publique Hopitaux Paris (APHP), Hopital Universitaire Bichat-Claude Bernard - APHP, Serv Pneumol A, Hop Bichat, AP HP
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  • Kevin Flaherty, Univ Michigan, University of Michigan, University of Michigan System, Div Pulm & Crit Care Med
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  • Ian Glaspole, Alfred Hlth, Allergy Immunol & Resp Med
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  • Jan Grutters, Univ Med Ctr Utrecht, Utrecht University, St. Antonius Hospital Utrecht, Utrecht University Medical Center, St Antonius Hosp, Div Heart & Lungs, ILD Ctr Excellence
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  • Yoshikazu Inoue, Natl Hosp Org Kinki Chuo Chest Med Ctr, Clin Res Ctr
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  • Maria Kokosi, Royal Brompton Hosp, Interstitial Lung Dis Unit, Dept Resp Med
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  • Yasuhiro Kondoh, Tosei Gen Hosp, Dept Resp Med & Allergy
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  • Vasileios Kouranos, Royal Brompton Hosp, Interstitial Lung Dis Unit, Dept Resp Med
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  • Michael Kreuter, German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg
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  • Kerri Johannson, Univ Calgary, University of Calgary, Dept Archaeol
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  • Eoin Judge, Mater Misericordiae Univ Hosp, University College Dublin, Resp Med & Natl Lung Transplantat Unit
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  • Brett Ley, Univ Calif San Francisco, University of California System, University of California San Francisco, Med
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  • George Margaritopoulos, Royal Brompton Hosp, Interstitial Lung Dis Unit, Dept Resp Med
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  • Fernando J. Martinez, Weill Cornell Med, Cornell University
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  • Maria Molina-Molina, Univ Hosp Bellvitge, Institut d'Investigacio Biomedica de Bellvitge (IDIBELL), IDIBELL, CIBERES
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  • Antonio Morais, Ctr Hosp Sao Joao, Sao Joao Hospital, Universidade do Porto, Pulmonol, Fac Med Porto
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  • Hilario Nunes, Paris 13 Univ, University of Paris Nord - Paris XIII, Assistance Publique Hopitaux Paris (APHP), Hopital Universitaire Avicenne - APHP, Universite Sorbonne Paris Cite-USPC (ComUE), Sorbonne Paris Cite, Serv Pneumol, Hop Avicenne
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  • Ganesh Raghu, Univ Washington, University of Washington, University of Washington Seattle, Ctr Interstitial Lung Dis
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  • Christopher J. Ryerson, Univ British Columbia, University of British Columbia, Med
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  • Moises Selman, Inst Nacl Enfermedades Resp Ismael Cosio Villegas
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  • Paolo Spagnolo, Univ Padua, University of Padua, Dept Cardiac Thorac & Vasc Sci, Sect Resp Dis
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  • Hiroyuki Taniguchi, Tosei Gen Hosp, Dept Resp Med & Allergy
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  • Sara Tomassetti, Osped GB Morgagni, Dept Dis Thorax
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  • Dominique Valeyre, Paris 13 Univ, University of Paris Nord - Paris XIII, Assistance Publique Hopitaux Paris (APHP), Hopital Universitaire Avicenne - APHP, Universite Sorbonne Paris Cite-USPC (ComUE), Sorbonne Paris Cite, Serv Pneumol, Hop Avicenne
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  • Marlies Wijsenbeek, Univ Hosp Rotterdam, Erasmus University Rotterdam, Erasmus MC, Dept Pulm Dis
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  • Wim Wuyts, Univ Hosp Leuven, University Hospital Leuven, KU Leuven, Resp Med
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  • David Hansell, Royal Brompton Hosp, Dept Thorac Imaging
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  • Athol Wells, Royal Brompton Hosp, Interstitial Lung Dis Unit
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  • IPF Project Consortium

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.

A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (kappa w). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index.

A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (kappa w= 0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index= 0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index= 0.74 IQR 0.72-0.75).

Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.

Original languageEnglish
Article number1700936
Book seriesEuropean Respiratory Journal. Supplement
Volume50
Issue2
Number of pages10
ISSN0903-1936
DOIs
Publication statusPublished - 1 Aug 2017

    Research areas

  • PARENCHYMAL LUNG-DISEASE, INTEROBSERVER AGREEMENT, INTERSTITIAL PNEUMONIA, MORTALITY, MANAGEMENT, UPDATE, UK

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