Aarhus University Seal / Aarhus Universitets segl

Ebbe Toftgaard Poulsen

  1. 2020
  2. E-pub ahead of print

    Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies. / Nielsen, Nadia Sukusu; Poulsen, Ebbe Toftgaard; Lukassen, Marie V; Chao Shern, Connie; Mogensen, Emilie Hage; Weberskov, Christian E; DeDionisio, Larry; Schauser, Leif; Moore, Tara C B; Otzen, Daniel E; Hjortdal, Jesper; Enghild, Jan J.

    In: Progress in Retinal and Eye Research, 28.01.2020, p. 100843.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. 2019
  4. Published

    The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation. / Poulsen, Ebbe Toftgaard; Nielsen, Nadia Sukusu; Scavenius, Carsten; Mogensen, Emilie Hage; Risør, Michael W.; Runager, Kasper; Lukassen, Marie V.; Rasmussen, Casper B.; Christiansen, Gunna; Richner, Mette; Vorum, Henrik; Enghild, Jan J.

    In: Journal of Biological Chemistry, Vol. 294, No. 31, 08.2019, p. 11817-11828.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. / Richner, Mette; Pallesen, Lone T; Ulrichsen, Maj; Poulsen, Ebbe T; Holm, Thomas H; Login, Hande; Castonguay, Annie; Lorenzo, Louis-Etienne; Gonçalves, Nádia P; Andersen, Olav M; Lykke-Hartmann, Karin; Enghild, Jan J; Rønn, Lars C B; Malik, Ibrahim J; De Koninck, Yves; Bjerrum, Ole J; Vægter, Christian B; Nykjær, Anders.

    In: Science Advances, Vol. 5, No. 6, eaav9946, 19.06.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. 2018
  7. Published

    Identification of redox-sensitive protein interactions in the human cornea. / Lukassen, Marie Vestergaard; Poulsen, Ebbe Toftgaard; Enghild, Jan J.

    2018. Abstract from Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, .

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  8. Published

    Structural characterization of corneal dystrophy-related TGFBIp mutants. / Nielsen, Nadia Sukusu; Ammitzbøll, Tania Aaquist; Thøgersen, Ida; Poulsen, Ebbe Toftgaard; Enghild, Jan J.

    In: Investigative Ophthalmology & Visual Science, Vol. 59, No. 9, E-Abstract 2254, 07.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  9. Published

    Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies. / Poulsen, Ebbe Toftgaard; Runager, Kasper; Nielsen, Nadia Sukusu; Lukassen, Marie V; Thomsen, Karen; Snider, Paige; Simmons, Olga; Vorum, Henrik; Conway, Simon J; Enghild, Jan J.

    In: F E B S Journal, Vol. 285, No. 1, 01.2018, p. 101-114.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. 2017
  11. Published

    Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor β-Induced Protein. / Nielsen, Nadia Sukusu; Juhl, Dennis Wilkens; Poulsen, Ebbe Toftgaard; Lukassen, Marie V; Poulsen, Emil Christian; Risør, Michael W; Scavenius, Carsten; Enghild, Jan Johannes.

    In: Biochemistry, Vol. 56, No. 49, 28.11.2017, p. 6470–6480.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Structural and Functional Implications of Human Transforming Growth Factor β-Induced Protein, TGFBIp, in Corneal Dystrophies. / García-Castellanos, Raquel; Nielsen, Nadia Sukusu; Runager, Kasper; Thøgersen, Ida B; Lukassen, Marie V; Poulsen, Ebbe T; Goulas, Theodoros; Enghild, Jan J; Gomis-Rüth, F Xavier.

    In: Structure, Vol. 25, No. 11, 11.2017, p. 1740-1750.e2.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Correction to: How glycosaminoglycans promote fibrillation of salmon calcitonin. / Malmos, Kirsten Gade; Bjerring, Morten; Jessen, Christian Moestrup; Nielsen, Erik Holm Toustrup; Poulsen, Ebbe T; Christiansen, Gunna; Vosegaard, Thomas; Skrydstrup, Troels; Enghild, Jan J; Pedersen, Jan Skov; Otzen, Daniel E.

    In: Journal of Biological Chemistry, Vol. 292, No. 38, 22.09.2017, p. 15992.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    The Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels. / Poulsen, Ebbe Toftgaard; Pedersen, Kata Wolff; Marzeda, Anna Maria; Enghild, Jan Johannes.

    In: Biochemistry, Vol. 56, No. 6, 14.02.2017, p. 896-902.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. / Poulsen, Ebbe T; Iannuzzi, Filomena; Rasmussen, Helle F; Maier, Thorsten J; Enghild, Jan J; Jørgensen, Arne L; Matrone, Carmela.

    In: Frontiers in Molecular Neuroscience, Vol. 10, 2017, p. 59.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. 2016
  17. Published

    How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin. / Malmos, Kirsten G; Bjerring, Morten; Jessen, Christian Moestrup; Nielsen, Erik Holm Toustrup; Poulsen, Ebbe Toftgaard; Christiansen, Gunna; Vosegaard, Thomas; Skrydstrup, Troels; Enghild, Jan J; Pedersen, Jan Skov; Otzen, Daniel E.

    In: Journal of Biological Chemistry, Vol. 291, No. 32, 05.08.2016, p. 16849-16862.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy. / Allen, Edwin H A; Courtney, David G; Atkinson, Sarah D; Moore, Johnny E; Mairs, Laura; Toftgaard Poulsen, Ebbe; Schiroli, Davide; Maurizi, Eleonora; Cole, Christian; Hickerson, Robyn P; James, John; Murgatroyd, Helen; Smith, Francis J D; MacEwen, Carrie; Enghild, Jan J; Nesbit, M Andrew; Leslie Pedrioli, Deena M; McLean, W H Irwin; Moore, C B Tara.

    In: Human Molecular Genetics, Vol. 25, No. 6, 11.01.2016, p. 1176-1191.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp). / Poulsen, Ebbe Toftgaard; Nielsen, Nadia Sukusu; Jensen, Morten Mørk; Nielsen, Esben; Hjortdal, Jesper Østergaard; Kim, Eung Kweon; Enghild, Jan J.

    In: Proteomics, Vol. 16, No. 3, 2016, p. 539-543.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Processing of TGFBIp by HtrA1 in relation to corneal dystrophies. / Nielsen, Nadia Sukusu; Poulsen, Ebbe Toftgaard; Lukassen, Marie; Thøgersen, Ida; Risør, Michael Wulff; Scavenius, Carsten; Runager, Kasper; Enghild, Jan J.

    In: Investigative Ophthalmology & Visual Science, Vol. 57 , No. 12, E-Abstract 4912, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  21. 2015
  22. Published

    Protein Composition of TGFBI-R124C- and TGFBI-R555W- Associated Aggregates Suggests Multiple Mechanisms Leading to Lattice and Granular Corneal Dystrophy. / Courtney, David G; Toftgaard Poulsen, Ebbe; Kennedy, Susan; Moore, Johnny E; Atkinson, Sarah D; Maurizi, Eleonora; Nesbit, M Andrew; Moore, C B Tara; Enghild, Jan J.

    In: Investigative Ophthalmology & Visual Science, Vol. 56, No. 8, 01.07.2015, p. 4653-61.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    The effects of hypochlorous acid and neutrophil proteases on the structure and function of extracellular superoxide dismutase. / Morales, Karla; Olesen, Mads Nikolaj; Poulsen, Ebbe Toftgaard; Larsen, Ulrike G; Enghild, Jan Johannes; Petersen, Steen Vang.

    In: Free Radical Biology & Medicine, Vol. 81, 04.2015, p. 38-46.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies. / Poulsen, Ebbe Toftgaard; Larsen, Agnete; Zollo, Alen; Jørgensen, Arne Lund; Sanggaard, Kristian Wejse; Enghild, Jan J.; Matrone, Carmela.

    In: International Journal of Molecular Sciences (Online), 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. 2014
  26. Published

    Unconditioned commercial embryo culture media contain a large variety of non-declared proteins : a comprehensive proteomics analysis. / Dyrlund, Thomas Franck; Kirkegaard, Kirstine; Poulsen, Ebbe Toftgaard; Sanggaard, Kristian W; Hindkjær, Johnny J; Kjems, Jørgen; Enghild, Jan J; Ingerslev, Hans Jakob.

    In: Human Reproduction, Vol. 29, No. 1, 27.08.2014, p. 2421-2430.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Proteomics of Fuchs' Endothelial Corneal Dystrophy Support That the Extracellular Matrix of Descemet's Membrane is Disordered. / Poulsen, Ebbe Toftgaard; Dyrlund, Thomas Franck; Runager, Kasper; Scavenius, Carsten; Krogager, Toke Peter ; Højrup, Peter; Thøgersen, Ida B; Sanggaard, Kristian Wejse; Vorum, Henrik; Hjortdal, Jesper; Enghild, Jan Johannes.

    In: Journal of Proteome Research, Vol. 13, No. 11, 21.05.2014, p. 4659-4667.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain. / Risør, Michael Wulff; Poulsen, Ebbe Toftgaard; Thomsen, Line R; Dyrlund, Thomas Franck; Nielsen, Tania Aaquist; Nielsen, Niels Christian; Sanggaard, Kristian Wejse; Enghild, Jan Johannes.

    In: Biochemistry, Vol. 53, No. 23, 20.05.2014, p. 3851-3857.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Insight into the Protein Composition of Immunoglobulin Light Chain Deposits of Eyelid, Orbital and Conjunctival Amyloidosis. / Nielsen, Nadia Sukusu; Poulsen, Ebbe Toftgaard; Klintworth, Gordon K.; Enghild, Jan J.

    In: Journal of Proteomics & Bioinformatics, Vol. S8, S8, 21.04.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene. / Poulsen, Ebbe Toftgaard; Runager, Kasper; Risør, Michael W; Dyrlund, Thomas Franck; Scavenius, Carsten; Karring, Henrik; Praetorius, Jeppe; Vorum, Henrik; Otzen, Daniel E; Klintworth, Gordon K; Enghild, Jan J.

    In: Proteomics - Clinical Applications, Vol. 8, No. 3-4, 04.2014, p. 168-177.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Coagulation Factor XIIIa Substrates in Human Plasma. Identification and Incorporation Into the Clot. / Nikolajsen, Camilla Lund; Dyrlund, Thomas Franck; Toftgaard Poulsen, Ebbe; Enghild, Jan J; Scavenius, Carsten.

    In: Journal of Biological Chemistry, Vol. 289, 07.03.2014, p. 6526-6534.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Distal Renal Tubules Are Deficient in Aggresome Formation and Autophagy upon Aldosterone Administration. / Cheema, Muhammad Umar; Damkier, Helle Hasager; Nielsen, Jakob; Poulsen, Ebbe Toftgaard; Enghild, Jan J; Fenton, Robert A; Praetorius, Jeppe.

    In: PLOS ONE, Vol. 9, No. 7, 2014, p. e101258.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. 2013
  34. Published

    Aldosterone and angiotensin II induced protein aggregation in renal proximal tubules. / Cheema, Muhammad Umar; Poulsen, Ebbe Toftgaard; Enghild, Jan J; Hoorn, Ewout; Fenton, Robert A; Praetorius, Jeppe.

    In: Physiological Reports, Vol. 1, No. 4, 09.2013, p. e00064.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  35. Published

    Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits. / Karring, Henrik; Poulsen, Ebbe Toftgaard; Runager, Kasper; Thøgersen, Ida B; Klintworth, Gordon K; Højrup, Peter; Enghild, Jan Johannes.

    In: Molecular Vision, Vol. 19, 12.04.2013, p. 861-876.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    Murine Extracellular Superoxide Dismutase Is Converted into the Inactive Fold by the Ser195Cys Mutation. / Scavenius, Carsten; Petersen, Jane Savskov; Thomsen, Line Rold; Poulsen, Ebbe Toftgaard; Valnickova Hansen, Zuzana; Bowler, Russel D; Oury, Tim D; Petersen, Steen Vang; Enghild, Jan Johannes.

    In: Biochemistry, Vol. 52, No. 19, 2013, p. 3369-3375.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    Proteomics of The Human Cornea : In Health and Disease. / Poulsen, Ebbe Toftgaard.

    2013.

    Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  38. 2012
  39. Published

    MS Data Miner : A web-based software tool to analyze, compare and share mass spectrometry protein identifications. / Dyrlund, Thomas Franck; Poulsen, Ebbe Toftgaard; Sonne-Schmidt, Carsten Scavenius; Sanggaard, Kristian W; Enghild, Jan J.

    In: Proteomics, Vol. 12, No. 18, 09.2012, p. 2792-2796.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Human cornea proteome : Identification and quantitation of the proteins of the three main layers including epithelium, stroma and endothelium. / Dyrlund, Thomas Franck; Poulsen, Ebbe Toftgaard; Sonne-Schmidt, Carsten Scavenius; Nikolajsen, Camilla Lund; Thøgersen, Ida B; Vorum, Henrik; Enghild, Jan Johannes.

    In: Journal of Proteome Research, Vol. 11, No. 8, 10.07.2012, p. 4231–4239 .

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. 2010
  42. Published

    The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis. / Petersen, Steen V; Thøgersen, Ida; Valnickova, Zuzana; Nielsen, Morten S; Petersen, Jane S; Poulsen, Ebbe Toftgaard; Jacobsen, Christian; Oury, Tim D; Moestrup, Søren K; Crapo, James D; Nielsen, Niels Christian; Kristensen, Torsten; Enghild, Jan J.

    In: Free Radical Biology & Medicine, Vol. 49, No. 5, 2010, p. 894-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review