Ebbe Boedtkjer

  1. 2019
  2. Accepted/In press

    The Acidic Tumor Microenvironment as a Driver of Cancer. / Boedtkjer, Ebbe; Pedersen, Stine F.

    In: Annual Review of Physiology, Vol. 82, 08.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  3. Published

    Na+,HCO3 cotransporter NBCn1 accelerates breast carcinogenesis. / Boedtkjer, Ebbe.

    In: Cancer and Metastasis Reviews, Vol. 38, No. 1-2, 06.2019, p. 165-178.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  4. Published

    Enhanced nitric oxide signaling amplifies vasorelaxation of human colon cancer feed arteries. / Voss, Ninna Cathrine Schmidt; Kold-Petersen, Henrik Houmann; Boedtkjer, Ebbe.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 316, No. 1, 01.01.2019, p. H245-H254.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Acidosis inhibits rhythmic contractions of human thoracic ducts. / Møller, Anders Lerche; Hjortdal, Vibeke E.; Bødtkjer, Donna Briggs; Boedtkjer, Ebbe.

    In: Physiological Reports, Vol. 7, No. 8, e14074, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Upregulated Na+/H+-exchange protects human colon cancer tissue against intracellular acidification. / Voss, Ninna Cathrine Schmidt; Kold-Petersen, Henrik; Henningsen, Mikkel Bak; Homilius, Casper; Boedtkjer, Ebbe.

    In: BioMed Research International, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. 2018
  8. Published

    A novel method to isolate retinal and brain microvessels from individual rats: microscopic and molecular biological characterization and application in hyperglycemic animals. / Li, Youhai; Lapina, Natalia; Weinzierl, Nina; Bonde, Lisbeth; Boedtkjer, Ebbe; Schubert, Rudolf; Moshage, Han; Wohlfahrt, Paulus; Schilling, Lothar.

    In: Vascular Pharmacology, Vol. 110, 11.2018, p. 24-30.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Na+ ,HCO3-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice. / Lee, Soojung; Axelsen, Trine V.; Jessen, Nicolai; Pedersen, Stine F.; Vahl, Pernille; Boedtkjer, Ebbe.

    In: Oncogene, Vol. 37, No. 41, 10.2018, p. 5569-5584.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Mechanisms of cellular acid-base regulation: implications for vascular function and breast carcinogenesis. / Bødtkjer, Ebbe.

    Aarhus University, 2018.

    Research output: Book/anthology/dissertation/reportDoctoral thesisResearch

  11. Published

    The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms. / Andersen, Anne Poder; Samsøe-Petersen, Jacob; Oernbo, Eva Kjer; Boedtkjer, Ebbe; Moreira, José M. A.; Kveiborg, Marie; Pedersen, Stine Falsig.

    In: International Journal of Cancer, Vol. 142, No. 12, 15.06.2018, p. 2529-2542.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Acid-base regulation and sensing: accelerators and brakes in metabolic regulation of cerebrovascular tone. / Boedtkjer, Ebbe.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 4, 04.2018, p. 588-602.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  13. Published

    Carbonic anhydrase inhibitors modify intracellular pH transients and contractions of rat middle cerebral arteries during CO2/HCO3 fluctuations. / Rasmussen, Jacob Korsbæk; Boedtkjer, Ebbe.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 3, 03.2018, p. 492-505.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Increased contractile function of human saphenous vein grafts harvested by "no-touch" technique. / Vestergaard, Lene; Benhassen, Leila Louise; Modrau, Ivy Susanne; de Paoli, Frank Vincenzo; Boedtkjer, Ebbe.

    In: Frontiers in Physiology, Vol. 8, 1135, 01.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Murine breast cancer feed arteries are thin-walled with reduced α1A-adrenoceptor expression and attenuated sympathetic vasocontraction. / Frølunde, Anne Sofie; Ohlenbusch, Marit Edna; Berg-Hansen, Kristoffer; Jessen, Nicolai; Kim, Sukhan; Boedtkjer, Ebbe.

    In: Breast Cancer Research, Vol. 20, 20, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. 2017
  17. Published

    Extracellular acidosis and very low [Na+] inhibit NBCn1- and NHE1-mediated net acid extrusion from mouse vascular smooth muscle cells. / Bonde, Lisbeth; Boedtkjer, Ebbe.

    In: Acta Physiologica, Vol. 221, No. 2, 10.2017, p. 129-141.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Crosstalk between cardiomyocyte-rich perivascular tissue and coronary arteries is reduced in the Zucker Diabetic Fatty rat model of type 2 diabetes mellitus. / Bonde, Lisbeth; Shokouh, Pedram; Jeppesen, Per Bendix; Boedtkjer, Ebbe.

    In: Acta Physiologica, Vol. 219, No. 1, 01.2017, p. 227-238.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    Increased NBCn1 expression, Na+/HCO3 co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. / Ng, Fu Liang; Boedtkjer, Ebbe; Witkowska, Katarzyna; Ren, Meixia; Zhang, Ruoxin; Tucker, Arthur; Aalkjær, Christian; Caulfield, Mark J; Ye, Shu.

    In: Human Molecular Genetics, Vol. 26, No. 5, 01.2017, p. 989-1002.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. 2016
  21. Published

    Negative news: Cl- and HCO3- in the vascular wall. / Boedtkjer, Ebbe; Matchkov, Vladimir; Bødtkjer, Donna Briggs; Aalkjær, Christian.

    In: Physiology, Vol. 31, 09.2016, p. 370-383.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  22. Published

    Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling. / Boedtkjer, Ebbe; Bentzon, Jacob F; Dam, Vibeke S; Aalkjaer, Christian.

    In: Cardiovascular Research, Vol. 111, No. 3, 01.08.2016, p. 227-39.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Prior renovascular hypertension does not predispose to atherosclerosis in mice. / Mortensen, Martin Bødtker; Nilsson, Line; Larsen, Tore G; Espeseth, Eirild; Bek, Marie; Bjørklund, Martin M; Hagensen, Mette K; Wolff, Anne; Gunnersen, Stine; Füchtbauer, Ernst-Martin; Boedtkjer, Ebbe; Bentzon, Jacob F.

    In: Atherosclerosis, Vol. 249, 06.2016, p. 157-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Extracellular HCO3- is sensed by mouse cerebral arteries: regulation of tone by receptor protein tyrosine phosphatase γ. / Boedtkjer, Ebbe; Berg-Hansen, Kristoffer; Bødtkjer, Donna Briggs; Aalkjær, Christian; Boron, Walter F.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 36, 05.2016, p. 965-980.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Disrupting Na+,HCO3-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. / Lee, Soojung; Axelsen, Trine Veje; Andersen, Anne Poder; Vahl, Pernille; Pedersen, Stine Helene Falsig; Boedtkjer, Ebbe.

    In: Oncogene, Vol. 35, No. 16, 21.04.2016, p. 2112-2122.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    New roles of factors from perivascular tissue in regulation of vascular tone. / Simonsen, Ulf; Boedtkjer, Ebbe.

    In: Acta Physiologica, Vol. 216, No. 2, 02.2016, p. 159-162.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. 2015
  28. Published

    Perivascular tissue inhibits rho-kinase-dependent smooth muscle Ca2+-sensitivity and endothelium-dependent H2S signalling in rat coronary arteries. / Jensen, Filip Aalbæk; Bonde, Lisbeth; Kim, Sukhan; Boedtkjer, Ebbe.

    In: The Journal of Physiology, 01.11.2015, p. 4747-4764.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Na+,HCO3--cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane. / Lee, Soojung; Mele, Marco; Vahl, Pernille; Christiansen, Peer Michael; Jensen, Vibeke Eleonora Dagmar; Bødtkjer, Ebbe.

    In: Pflügers Archiv - European Journal of Physiology, Vol. 467, No. 2, 2015, p. 367-377.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors. / Steinkamp, Anne-Dorothee; Seling, Nico; Lee, Soojung; Boedtkjer, Ebbe; Bolm, Carsten.

    In: MedChemComm, Vol. 6, 2015, p. 2163-2169.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. 2014
  32. Published

    Cation-coupled HCO3 transporters. / Aalkjær, Christian; Boedtkjer, Ebbe; Choi, Inyeong; Lee, Soojung.

    In: Comprehensive Physiology, Vol. 4, No. 4, 10.2014, p. 1605-1637.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  33. Published

    Regulation and roles of bicarbonate transporters in cancer. / Gorbatenko, Andrej; Olesen, Christina Wilkens; Boedtkjer, Ebbe; Pedersen, Stine Helene Falsig.

    In: Frontiers in Physiology, Vol. 5, 130, 03.2014, p. 1-15.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  34. Published

    Intracellular acidification alters myogenic responsiveness and vasomotion of mouse middle cerebral arteries. / Thomsen, Axel Bjarke Korsgaard; Kim, Sukhan; Jensen, Filip Aalbæk; Aalkjær, Christian; Boedtkjer, Ebbe.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 34, 2014, p. 161-168.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  35. 2013
  36. Published

    Disturbed acid-base transport: an emerging cause of hypertension. / Boedtkjer, Ebbe; Aalkjær, Christian.

    In: Frontiers in Physiology, Vol. 4, 388, 24.12.2013, p. 1-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  37. Published

    Acid-base transporters modulate cell migration, growth and proliferation: implications for structure development and remodeling of resistance arteries? / Boedtkjer, Ebbe; Aalkjær, Christian.

    In: Trends in Cardiovascular Medicine, Vol. 23, No. 3, 04.2013, p. 59-65.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Splice cassette II of NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. / Danielsen, Andreas Aalkjær; Parker, Mark D.; Lee, Soojung; Boron, Walter F.; Aalkjær, Christian; Boedtkjer, Ebbe.

    In: Journal of Biological Chemistry, Vol. 288, No. 12, 22.03.2013, p. 8146-8155.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Contribution of Na+,HCO3--cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7). / Boedtkjer, Ebbe; Moreira, José M. A.; Mele, Marco; Vahl, Pernille; Wielenga, Vera T.; Christiansen, Peer Michael; Jensen, Vibeke Eleonora Dagmar; Pedersen, Stine F.; Aalkjær, Christian.

    In: International Journal of Cancer, Vol. 132, No. 6, 15.03.2013, p. 1288-1299.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    Endothelial alkalinisation inhibits gap junction communication and endothelium-derived hyperpolarisations in mouse mesenteric arteries. / Boedtkjer, Ebbe; Kim, Sukhan; Aalkjær, Christian.

    In: Journal of Physiology, Vol. 591, No. 6, 15.03.2013, p. 1447-1461.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. 2012
  42. Published

    NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pHi in the vascular wall. / Boedtkjer, Ebbe; Damkier, Helle; Aalkjær, Christian.

    In: Journal of Physiology, Vol. 590, No. 8, 15.04.2012, p. 1895-1906.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. Published

    Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: Similarities, differences, and implications for cancer therapy. / Boedtkjer, Ebbe; Bunch, Lennart; Pedersen, Stine F.

    In: Current Pharmaceutical Design, Vol. 18, No. 10, 04.2012, p. 1345-1371.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Cotransport Inhibitor S0859: In Vitro Efficacy Studies in Breast Cancer Cells. / Larsen, Ann M.; Krogsgaard-Larsen, Niels; Lauritzen, Gitte; Olesen, Christina W.; Hansen, Steen Honoré; Boedtkjer, Ebbe; Pedersen, Stine F.; Bunch, Lennart.

    In: ChemMedChem, Vol. 7, No. 10, 2012, p. 1808-1814.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    Intracellular pH in the resistance vasculature: regulation and functional implications. / Boedtkjer, Ebbe; Aalkjær, Christian.

    In: Journal of Vascular Research, Vol. 49, No. 6, 2012, p. 479-496.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. 2011
  47. Published

    Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat. / Stankevicius, Edgaras; Dalsgaard, Thomas; Krøigaard, Christel; Beck, Lilliana; Boedtkjer, Ebbe; Misfeldt, Mikkel Wölck; Nielsen, Gorm; Schjørring, Olav; Hughes, Alun; Simonsen, Ulf.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 339, No. 3, 12.2011, p. 842-850.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  48. Published

    Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice. / Boedtkjer, Ebbe; Prætorius, Jeppe; Matchkov, Vladimir V; Stankevicius, Edgaras; Mogensen, Susie; Füchtbauer, Annette C; Simonsen, Ulf; Füchtbauer, Ernst-Martin; Aalkjaer, Christian.

    In: Circulation, Vol. 124, No. 17, 26.09.2011, p. 1819-1829.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. 2010
  50. Published

    Expression and function of Na+-dependent acid-base transporters in the resistance vasculature and beyond. / Boedtkjer, Ebbe.

    Aarhus University, 2010.

    Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  51. Published

    NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance. / Lauritzen, Gitte; Jensen, M.B.F.; Boedtkjer, Ebbe; Olsen, R.D.; Aalkjær, Christian; Nylandsted, J.; Pedersen, Stine Falsig.

    In: Experimental Cell Research, Vol. 316, No. 15, 2010, p. 2538-2553.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. 2009
  53. Published

    Insulin inhibits Na+/H+-exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2. / Bødtkjer, Ebbe; Aalkjær, Christian.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 296, 2009, p. H247-H255.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. 2008
  55. Published

    Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice. / Bødtkjer, Ebbe; Prætorius, Jeppe; Füchtbauer, Ernst-Martin; Aalkjær, Christian.

    In: American Journal of Physiology: Cell Physiology, Vol. 294, No. 2, 2008, p. C591-C603.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  56. Published

    Vasomotion has chloride-dependency in rat mesenteric small arteries. / Bødtkjer, Donna Marie Briggs; Matchkov, Vladimir; Bødtkjer, Ebbe; Nilsson, Holger; Aalkjær, Christian.

    In: Pflügers Archiv - European Journal of Physiology, Vol. 457, No. 2, 2008, p. 389-404.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  57. 2006
  58. Published

    NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells. / Bødtkjer, Ebbe; Prætorius, Jeppe; Aalkjær, Christian.

    In: Circulation Research, Vol. 98, No. 4, 2006, p. 515-23.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review