Research output per year
Research output per year
- 1 - 50 out of 51 results
Search results
-
2025
Association Between Polygenic Risk Scores and Treatment Response to Antidepressants, Benzodiazepines, and Antihistamines in Anxiety and Depression
Markant, A., Tabrizi, F., Grönvall, H., Speed, D. & Åhs, F., May 2025, In: Biological Psychiatry: Global Open Science. 5, 3, 9 p., 100470.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Does the Path From Cigarette Smoking to Suicide Death Go Through the Hospital? A Causal Mediation Analysis in a National Canadian Sample
Balbuena, L., Åhs, F., Peters, E., Mendes-Silva, A. & Speed, D., 2025, In: Tobacco Use Insights. 18Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
-
Genome-wide association meta-analyses of drug-resistant epilepsy
Epi25 Collaborative, May 2025, In: EBioMedicine. 115, p. 105675 105675.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Henry, A., Mo, X., Finan, C., Chaffin, M. D., Speed, D., Issa, H., Denaxas, S., Ware, J. S., Zheng, S. L., Malarstig, A., Gratton, J., Bond, I., Roselli, C., Miller, D., Chopade, S., Schmidt, A. F., Abner, E., Adams, L., Andersson, C. & Aragam, K. G. & 5 others, , Apr 2025, In: Nature Genetics. 57, 4, p. 815-828 14 p., 163.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Heritability and polygenic load for comorbid anxiety and depression
Tabrizi, F., Rosén, J., Grönvall, H., William-Olsson, V. R., Arner, E., Magnusson, P. K., Palm, C., Larsson, H., Viktorin, A., Bernhardsson, J., Björkdahl, J., Jansson, B., Sundin, Ö., Zhou, X., Speed, D. & Åhs, F., Dec 2025, In: Translational Psychiatry. 15, 1, p. 98 10 p., 98.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
Recent Statistical Innovations in Human Genetics
Balding, D. J. & Speed, D., 27 Jun 2025, (E-pub / Early view) In: Annals of Human Genetics. p. e12606Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
-
2024
Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates
Speed, D. & Evans, D. M., Apr 2024, In: American Journal of Human Genetics. 111, 4, p. 680-690 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
-
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy
Zheng, S. L., Henry, A., Cannie, D., Lee, M., Miller, D., McGurk, K. A., Bond, I., Xu, X., Issa, H., Francis, C., De Marvao, A., Theotokis, P. I., Buchan, R. J., Speed, D., Abner, E., Adams, L., Aragam, K. G., Ärnlöv, J., Raja, A. A. & Backman, J. D. & 5 others, , Dec 2024, In: Nature Genetics. 56, 12, p. 2646-2658 13 p., 2254.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access7 Citations (Scopus) -
The heritability of fitness in a wild annual plant population with hierarchical size structure
Schoen, D. J. & Speed, D., 1 Oct 2024, In: Evolution. 78, 10, p. 1739-1745 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
-
Using the Bayesian variational spike and slab model in a genome-wide association study for finding associated loci with bipolar disorder
Kazemi Naeini, M., Akbarzadeh, M., Kazemi, I., Speed, D. & Hosseini, S. M., May 2024, In: Annals of Human Genetics. 88, 3, p. 212-246 35 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
-
2023
Genetic liability to bipolar disorder and body mass index: A bidirectional two-sample mendelian randomization study
Byg, L. M., Speed, M., Speed, D. & Østergaard, S. D., Feb 2023, In: Bipolar Disorders. 25, 1, p. 25-31 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access5 Citations (Scopus) -
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
Speed, D. & International League Against Epilepsy Consortium on Complex Epilepsies, Sept 2023, In: Nature Genetics. 55, 9, p. 1471-1482 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile77 Citations (Scopus)27 Downloads (Pure) -
LDAK-GBAT: Fast and powerful gene-based association testing using summary statistics
Berrandou, T.-E., Balding, D. & Speed, D., Jan 2023, In: American Journal of Human Genetics. 110, 1, p. 23-29 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
Participation bias in the UK Biobank distorts genetic associations and downstream analyses
Schoeler, T., Speed, D., Porcu, E., Pirastu, N., Pingault, J. B. & Kutalik, Z., Jul 2023, In: Nature Human Behaviour. 7, 7, p. 1216-1227 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile154 Citations (Scopus)9 Downloads (Pure) -
Using polygenic risk scores to investigate the evolution of smoking and mental health outcomes in UK biobank participants
Balbuena, L., Peters, E. & Speed, D., Nov 2023, In: Acta Psychiatrica Scandinavica. 148, 5, p. 447-456 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)9 Downloads (Pure) -
2022
Genome-wide association, prediction and heritability in bacteria with application to Streptococcus pneumoniae
Mallawaarachchi, S., Tonkin-Hill, G., Croucher, N. J., Turner, P., Speed, D., Corander, J. & Balding, D., 1 Mar 2022, In: NAR Genomics & Bioinformatics. 4, 1, 11 p., lqac011.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access6 Citations (Scopus) -
Graph pangenome captures missing heritability and empowers tomato breeding
Zhou, Y., Zhang, Z., Bao, Z., Li, H., Lyu, Y., Zan, Y., Wu, Y., Cheng, L., Fang, Y., Wu, K., Zhang, J., Lyu, H., Lin, T., Gao, Q., Saha, S., Mueller, L., Fei, Z., Städler, T., Xu, S. & Zhang, Z. & 2 others, , 16 Jun 2022, In: Nature. 606, 7914, p. 527-534 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile251 Citations (Scopus)43 Downloads (Pure) -
Heritability of insidious uveitis in Appaloosa horses
Kingsley, N. B., Sandmeyer, L., Norton, E. M., Speed, D., Dwyer, A., Lassaline, M., McCue, M. & Bellone, R. R., Dec 2022, In: Animal Genetics. 53, 6, p. 872-877Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
3 Citations (Scopus) -
Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis
Grace, C. A., Sousa Carvalho, K. S., Sousa Lima, M. I., Costa Silva, V., Reis-Cunha, J. L., Brune, M. J., Forrester, S., Pedrozo E Silva de Azevedo, C. D. M., Costa, D. L., Speed, D., Mottram, J. C., Jeffares, D. C. & Costa, C. H. N., Dec 2022, In: mBio. 13, 6, p. e0206822Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access8 Citations (Scopus) -
SNP-based heritability and selection analyses: Improved models and new results
Speed, D., Kaphle, A. & Balding, D. J., May 2022, In: BioEssays. 44, 5, p. e2100170 2100170.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile13 Citations (Scopus)89 Downloads (Pure) -
The effects of common genetic variation in 96 genes involved in thyroid hormone regulation on TSH and FT4 concentrations
Sterenborg, R. B. T. M., Galesloot, T. E., Teumer, A., Netea-Maier, R. T., Speed, D., Meima, M. E., Visser, W. E., Smit, J. W. A., Peeters, R. P. & Medici, M., 1 Jun 2022, In: The Journal of Clinical Endocrinology & Metabolism. 107, 6, p. e2276-e2283 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)45 Downloads (Pure) -
2021
Bipolar disorder and cannabis use: A bidirectional two-sample Mendelian randomization study
Jefsen, O. H., Speed, M., Speed, D. & Østergaard, S. D., Nov 2021, In: Addiction Biology. 26, 6, 7 p., 13030.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
16 Citations (Scopus) -
Improved genetic prediction of complex traits from individual-level data or summary statistics
Zhang, Q., Privé, F., Vilhjálmsson, B. & Speed, D., 1 Dec 2021, In: Nature Communications. 12, 1, 9 p., 4192.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access91 Citations (Scopus) -
Signatures of TSPAN8 variants associated with human metabolic regulation and diseases
De, T., Goncalves, A., Speed, D., Froguel, P., NFBC consortium, Gaffney, D. J., Johnson, M. R., Jarvelin, M.-R. & Coin, L. J., 20 Aug 2021, In: iScience. 24, 8, 16 p., 102893.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
6 Citations (Scopus) -
2020
Estimating narrow-sense heritability using family data from admixed populations
Athanasiadis, G., Speed, D., Andersen, M. K., Appel, E. V. R., Grarup, N., Brandslund, I., Jørgensen, M. E., Larsen, C. V. L., Bjerregaard, P., Hansen, T. & Albrechtsen, A., 1 Jun 2020, In: Heredity. 124, 6, p. 751-762 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
Evaluating and improving heritability models using summary statistics
Speed, D., Holmes, J. & Balding, D. J., 1 Apr 2020, In: Nature Genetics. 52, 4, p. 458-462 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
109 Citations (Scopus) -
Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster
Nagel, M., Speed, D., van der Sluis, S. & Østergaard, S. D., 1 May 2020, In: Acta Psychiatrica Scandinavica. 141, 5, p. 476-478 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
27 Citations (Scopus) -
2019
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Alves, A. C., De Silva, N. M. G., Karhunen, V., Sovio, U., Das, S., Rob Taal, H., Warrington, N. M., Lewin, A. M., Kaakinen, M., Cousminer, D. L., Thiering, E., Timpson, N. J., Bond, T. A., Lowry, E., Brown, C. D., Estivill, X., Lindi, V., Bradfield, J. P., Geller, F. & Speed, D. & 32 others, , 2019, In: Science Advances. 5, 9, 18 p., eaaw3095.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access93 Citations (Scopus) -
Investigating the association between body fat and depression via Mendelian randomization
Speed, M. S., Jefsen, O. H., Børglum, A. D., Speed, D. & Østergaard, S. D., 1 Dec 2019, In: Translational Psychiatry. 9, 1, 184.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access105 Citations (Scopus) -
Investigating the causal relationship between neuroticism and depression via Mendelian Randomization
Speed, D., Hemani, G., Speed, M. S., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Børglum, A. D., 2019, In: Acta Psychiatrica Scandinavica. 139, 4, p. 395-397 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
Open Access29 Citations (Scopus) -
SumHer better estimates the SNP heritability of complex traits from summary statistics
Speed, D. & Balding, D. J., 1 Feb 2019, In: Nature Genetics. 51, 2, p. 277-284 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access150 Citations (Scopus) -
Summary statistic analyses can mistake confounding bias for heritability
Holmes, J. B., Speed, D. & Balding, D. J., Dec 2019, In: Genetic Epidemiology. 43, 8, p. 930-940 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
9 Citations (Scopus) -
2018
Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data
23 and Me Research Team, 2018, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 177, 7, p. 641-657 17 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
163 Citations (Scopus) -
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients
EPIGEN Consortium;, 2018, In: Neurology. 90, 4, p. e332-e341 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
33 Citations (Scopus) -
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
The International League Against Epilepsy Consortium on Complex Epilepsies, 1 Dec 2018, In: Nature Communications. 9, 1, 5269.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access316 Citations (Scopus) -
Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease
Kia, D. A., Noyce, A. J., White, J., Speed, D., Nicolas, A., IPDGC collaborators, Burgess, S., Lawlor, D. A., Davey Smith, G., Singleton, A., Nalls, M. A., Sofat, R. & Wood, N. W., 2018, In: Annals of Neurology. 84, 2, p. 191-199 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access41 Citations (Scopus) -
2017
Reevaluation of SNP heritability in complex human traits
Speed, D., Cai, N., Johnson, M. R., Nejentsev, S. & Balding, D. J., 1 Jul 2017, In: Nature Genetics. 49, 7, p. 986-992 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
278 Citations (Scopus) -
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
Jeffares, D. C., Jolly, C., Hoti, M., Speed, D., Shaw, L., Rallis, C., Balloux, F., Dessimoz, C., Bähler, J. & Sedlazeck, F. J., 24 Jan 2017, In: Nature Communications. 8, 11 p., 14061.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access444 Citations (Scopus) -
2016
Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families
NIDDK Inflammatory Bowel Disease Genetics Consortium, 1 Oct 2016, In: Gastroenterology. 151, 4, p. 698-709 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
54 Citations (Scopus) -
2015
Relatedness in the post-genomic era: is it still useful?
Speed, D. & Balding, D. J., 2015, In: Nature Reviews. Genetics. 16, 1, p. 33-44 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
205 Citations (Scopus) -
The genomic and phenotypic diversity of Schizosaccharomyces pombe
Jeffares, D. C., Rallis, C., Rieux, A., Speed, D., Prevorovsk, M., Mourier, T., Marsellach, F. X., Iqbal, Z., Lau, W. & Cheng, T. M., 2015, In: Nature Genetics. 47, 3, p. 235-241 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
132 Citations (Scopus) -
2014
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
Speed, D., D, S., C, H., S, P., I, T., A, C., A, J., H, E., M, D. I., M, T., T, D., D, S., PE, S., M, J., P, C., M, K., S, H., M, N., R, Y. & M, T. & 13 others, , 2014, In: Human Molecular Genetics.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
32 Citations (Scopus) -
Describing the genetic architecture of epilepsy through heritability analysis.
Speed, D., D, S., TJ, O., A, P., K, S., AG, M., DJ, B. & MR, J., 2014, In: Brain.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
73 Citations (Scopus) -
Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.
Speed, D., J, K., D, S., R, P., C, T., R, M. & J, F., 2014, In: P L o S One.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
9 Citations (Scopus) -
MultiBLUP: improved SNP-based prediction for complex traits.
Speed, D., D, S. & DJ, B., 2014, In: Genome Research.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
199 Citations (Scopus) -
2013
Genome-wide analysis of blood pressure variability and ischemic stroke.
Speed, D., S, Y., I, C., PB, M., MS, K., MA, N., S, B., YC, C., WM, C., R, M., NS, M., EG, H., D, S., N, H., M, P., PE, R., P, S., A, S., DC, S. & JM, M. & 16 others, , 2013, In: Stroke.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
19 Citations (Scopus) -
Long-stay patients with cancer on the intensive care unit: characteristics, risk factors, and clinical outcomes.
Speed, D., PC, G., A, A., D, S. & TJ, W., 2013, In: British Journal of Anaesthesia.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus) -
Response to Lee et al.: SNP-based heritability analysis with dense data.
Speed, D., D, S., G, H., MR, J. & DJ, B., 2013, In: American Journal of Human Genetics.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
13 Citations (Scopus) -
2012
Improved heritability estimation from genome-wide SNPs.
Speed, D., D, S., G, H., MR, J. & DJ, B., 2012, In: American Journal of Human Genetics.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
487 Citations (Scopus) -
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Speed, D., C, C., SP, S., SF, C., G, T., OM, R., MJ, D., D, S., AG, L., S, S., Y, Y., S, G., G, H., G, H., A, B., R, R., S, M., Group, M., A, L. & A, G. & 13 others, , 2012, In: Nature.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
4579 Citations (Scopus)