Ditte Demontis

2025

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses

Nielsen, T. T., Bali, P., Grove, J., Mohr-Jensen, C., Werge, T., Dalsgaard, S., Børglum, A. D., Sonuga-Barke, E., Minnis, H., Corfield, E. C., Tbartz van Elst, L., Mattheisen, M., de Wit, M. M., Uddin, M. J., Anney, R. J. L., Scherer, S. W., Bourgeron, T., Polderman, T. J. C., Autism Spectrum Working Group of the Psychiatric Genomics Consortium & Demontis, D., 9 May 2025, (E-pub / Early view) In: JAMA Psychiatry. e0243639.

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Neuropsychiatric polygenic scores are weak predictors of professional categories

Voloudakis, G., Therrien, K., Tomasi, S., Rajagopal, V. M., Choi, S. W., Demontis, D., Fullard, J. F., Børglum, A. D., O’Reilly, P. F., Hoffman, G. E. & Roussos, P., Mar 2025, In: Nature Human Behaviour. 9, 3, p. 595-608 14 p., 2457.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation

Kaas, M., Chofflet, N., Bicer, D., Skeldal, S., Duan, J., Feller, B., Vilstrup, J., Groth, R., Sivagurunathan, S., Dashti, H., Pedersen, J. S., Werge, T., Børglum, A. D., Cimini, B. A., Jones, T. R., Claussnitzer, M., Madsen, P., Takahashi, H., Demontis, D. & Thirup, S. & 1 others, Glerup, S., 20 Feb 2025, bioRxiv.

Research output: Working paper/Preprint › Preprint

The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder

Christiansen, G. B., Petersen, L. V., Chatwin, H., Yilmaz, Z., Schendel, D., Bulik, C. M., Grove, J., Brikell, I., Semark, B. D., Holde, K., Abdulkadir, M., Hübel, C., Albiñana, C., Vilhjálmsson, B. J., Børglum, A. D., Demontis, D., Mortensen, P. B. & Larsen, J. T., May 2025, In: Molecular Psychiatry. 30, 5, p. 2127-2136 10 p., 132.

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Open Access

1 Citation (Scopus)

2024

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Garcia-Argibay, M., Brikell, I., Thapar, A., Lichtenstein, P., Lundström, S., Demontis, D. & Larsson, H., Mar 2024, In: Biological Psychiatry. 95, 5, p. 444-452 9 p.

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Open Access

10 Citations (Scopus)

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Johnson, E. C., Austin-Zimmerman, I., Thorpe, H. H. A., Levey, D. F., Baranger, D. A. A., Colbert, S. M. C., Demontis, D., Khokhar, J. Y., Davis, L. K., Edenberg, H. J., Di Forti, M., Sanchez-Roige, S., Gelernter, J. & Agrawal, A., Oct 2024, In: Neuropsychopharmacology. 49, 11, p. 1655-1665 11 p.

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Open Access

2 Citations (Scopus)

Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study

Breinbjerg, A., Jørgensen, C. S., Walters, G. B., Grove, J., Als, T. D., Kamperis, K., Stéfansdóttir, L., Thirstrup, J. P., Borg, B., Albiñana, C., Vilhjálmsson, B. J., Eðvarðsson, V. Ö., Stefánsson, H., Mortensen, P. B., Agerbo, E., Werge, T., Børglum, A., Demontis, D., Stefánsson, K. & Rittig, S. & 1 others, Christensen, J. H., 1 Dec 2024, In: The Journal of Urology. 212, 6, p. 851-861 11 p.

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2 Citations (Scopus)

Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders

Koller, D., Mitjans, M., Kouakou, M., Friligkou, E., Cabrera-Mendoza, B., Deak, J. D., Llonga, N., Pathak, G. A., Stiltner, B., Løkhammer, S., Levey, D. F., Zhou, H., Hatoum, A. S., Kember, R. L., Kranzler, H. R., Stein, M. B., Corominas, R., Demontis, D., Artigas, M. S. & Ramos-Quiroga, J. A. & 4 others, Gelernter, J., Ribasés, M., Cormand, B. & Polimanti, R., Mar 2024, In: Psychiatry Research. 333, 12 p., 115758.

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Open Access

4 Citations (Scopus)

Polygenic risk of mental disorders and subject-specific school grades

Jefsen, O. H., Holde, K., McGrath, J. J., Rajagopal, V. M., Albiñana, C., Vilhjálmsson, B. J., Grove, J., Agerbo, E., Yilmaz, Z., Plana-Ripoll, O., Munk-Olsen, T., Demontis, D., Børglum, A., Mors, O., Bulik, C. M., Mortensen, P. B. & Petersen, L. V., 1 Aug 2024, In: Biological Psychiatry. 96, 3, p. 222-229 8 p.

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5 Citations (Scopus)

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Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD

Patel, K. H. S., Walters, G. B., Stefánsson, H., Stefánsson, K., Degenhardt, F., Nothen, M., Van Der Veen, T., Demontis, D., Borglum, A., Kristiansen, M., Bass, N. J. & McQuillin, A., Jun 2024, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 195, 4, e32967.

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Open Access

Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD

Nielsen, T. T., Duan, J., Levey, D. F., Walters, G. B., Johnson, E. C., Thorgeirsson, T., Werge, T., Mortensen, P. B., Stefansson, H., Stefansson, K., Hougaard, D. M., Agrawal, A., Gelernter, J., Grove, J., Børglum, A. & Demontis, D., Sept 2024, In: Nature Mental Health. 2, 9, p. 1071-1083 13 p., 108535.

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1 Citation (Scopus)

The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder

Petersen, L., Christiansen, G., Chatwin, H., Yilmaz, Z., Schendel, D., Bulik, C., Grove, J., Brikell, I., Semark, B., Holde, K., Abdulkadir, M., Hubel, C., Albiñana, C., Vilhjálmsson, B., Borglum, A., Demontis, D. & Mortensen, P., 17 Jul 2024, (Research square).

Research output: Working paper/Preprint › Preprint

2023

Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

ADHD Working Group of the Psychiatric Genomics Consortium, Apr 2023, In: Nature Genetics. 55, 4, p. 730 1 p.

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5 Citations (Scopus)

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

Als, T. D., Kurki, M. I., Grove, J., Voloudakis, G., Therrien, K., Tasanko, E., Nielsen, T. T., Naamanka, J., Veerapen, K., Levey, D. F., Bendl, J., Bybjerg-Grauholm, J., Zeng, B., Demontis, D., Rosengren, A., Athanasiadis, G., Bækved-Hansen, M., Qvist, P., Bragi Walters, G. & Thorgeirsson, T. & 23 others, Stefánsson, H., Musliner, K. L., Rajagopal, V. M., Farajzadeh, L., Thirstrup, J., Vilhjálmsson, B. J., McGrath, J. J., Mattheisen, M., Meier, S., Agerbo, E., Stefánsson, K., Nordentoft, M., Werge, T., Hougaard, D. M., Mortensen, P. B., Stein, M. B., Gelernter, J., Hovatta, I., Roussos, P., Daly, M. J., Mors, O., Palotie, A. & Børglum, A. D., Jul 2023, In: Nature Medicine. 29, 7, p. 1832-1844 13 p.

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Open Access

120 Citations (Scopus)

Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes

Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B. & Cormand, B., Oct 2023, In: Neuroscience and Biobehavioral Reviews. 153, 20 p., 105313.

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10 Citations (Scopus)

20 Downloads (Pure)

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Demontis, D., Walters, G. B., Athanasiadis, G., Walters, R., Therrien, K., Nielsen, T. T., Farajzadeh, L., Voloudakis, G., Bendl, J., Zeng, B., Zhang, W., Grove, J., Als, T. D., Duan, J., Satterstrom, F. K., Bybjerg-Grauholm, J., Bækved-Hansen, M., Gudmundsson, O. O., Magnusson, S. H. & Baldursson, G. & 28 others, Davidsdottir, K., Haraldsdottir, G. S., Agerbo, E., Hoffman, G. E., Dalsgaard, S., Martin, J., Ribasés, M., Boomsma, D. I., Soler Artigas, M., Roth Mota, N., Howrigan, D., Medland, S. E., Zayats, T., Rajagopal, V. M., Nordentoft, M., Mors, O., Hougaard, D. M., Mortensen, P. B., Daly, M. J., Faraone, S. V., Stefansson, H., Roussos, P., Franke, B., Werge, T., Neale, B. M., Stefansson, K., Børglum, A. D. & ADHD Working Group of the Psychiatric Genomics Consortium, Feb 2023, In: Nature Genetics. 55, 2, p. 198-208 11 p.

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Open Access

291 Citations (Scopus)

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

Rajagopal, V. M., Ganna, A., Coleman, J. R. I., Allegrini, A., Voloudakis, G., Grove, J., Als, T. D., Horsdal, H. T., Petersen, L., Appadurai, V., Schork, A., Buil, A., Bulik, C. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Mors, O., Nordentoft, M., Werge, T. & iPSYCH-Broad Consortium & 7 others, Mortensen, P. B., Breen, G., Roussos, P., Plomin, R., Agerbo, E., Børglum, A. D. & Demontis, D., Jan 2023, In: Scientific Reports. 13, 429.

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Open Access

12 Citations (Scopus)

GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

Docherty, A. R., Mullins, N., Ashley-Koch, A. E., Qin, X., Coleman, J. R. I., Shabalin, A., Kang, J. E., Murnyak, B., Wendt, F., Adams, M., Campos, A. I., DiBlasi, E., Fullerton, J. M., Kranzler, H. R., Bakian, A. V., Monson, E. T., Rentería, M. E., Walss-Bass, C., Andreassen, O. A. & Behera, C. & 228 others, Bulik, C. M., Edenberg, H. J., Kessler, R. C., John Mann, J., Nurnberger, J. I., Pistis, G., Streit, F., Ursano, R. J., Polimanti, R., Dennis, M., Garrett, M., Hair, L., Harvey, P., Hauser, E. R., Hauser, M. A., Huffman, J., Jacobson, D., Madduri, R., McMahon, B., Oslin, D. W., Trafton, J., Awasthi, S., Berrettini, W. H., Bohus, M., Chang, X., Chen, H. C., Chen, W. J., Christensen, E. D. M. D., Crow, S., Duriez, P., Edwards, A. C., Fernández-Aranda, F., Galfalvy, H., Gandal, M., Gorwood, P., Guo, Y., Hafferty, J. D., Hakonarson, H., Halmi, K. A., Hishimoto, A., Jain, S., Jamain, S., Jiménez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Kim, M., Klump, K. L., Levey, D. F., Li, D., Liao, S. C., Lieb, K., Lilenfeld, L., Marshall, C. R., Mitchell, J. E., Okazaki, S., Otsuka, I., Pinto, D., Powers, A., Ramoz, N., Ripke, S., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Starnawska, A., Strober, M., Su, M. H., Thornton, L. M., Treasure, J., Ware, E. B., Watson, H. J., Witt, S. H., Blake Woodside, D., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Alda, M., Alfredsson, L., Appadurai, V., Artigas, M. S., Van Der Auwera, S., Helena Azevedo, M., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Castelao, E., Cervilla, J. A., Chaumette, B., Corvin, A., Craddock, N., Djurovic, S., Foo, J. C., Forstner, A. J., Frye, M., Gatt, J. M., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamshere, M. L., Hartmann, A. M., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Krebs, M. O., Landén, M., Leboyer, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Mayoral, F., McElroy, S. L., McGrath, P., McGuffin, P., McQuillin, A., Mehta, D., Melle, I., Mitchell, P. B., Molina, E., Morken, G., Nievergelt, C., Nöthen, M. M., O'Donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribasés, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Trzaskowski, M., Tsuang, M. T., Turecki, G., Vilar-Ribó, L., Vincent, J. B., Völzke, H., Walters, J. T. R., Weickert, C. S., Weickert, T. W., Weissman, M. M., Williams, L. M., Wray, N. R., Zai, C. C., Agerbo, E., Børglum, A. D., Breen, G., Demontis, D., Erlangsen, A., Gelernter, J., Glatt, S. J., Hougaard, D. M., Hwu, H. G., Kuo, P. H., Lewis, C. M., Li, Q. S., Liu, C. M., Martin, N. G., McIntosh, A. M., Medland, S. E., Mors, O., Nordentoft, M., Olsen, C. M., Porteous, D., Smith, D. J., Stahl, E. A., Stein, M. B., Wasserman, D., Werge, T., Whiteman, D. C., Willour, V., Coon, H., Beckham, J. C., Kimbrel, N. A. & Ruderfer, D. M., 2023, In: American Journal of Psychiatry. 180, 10, p. 723-738 16 p.

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Open Access

55 Citations (Scopus)

Interplay of ADHD Polygenic Liability With Birth-Related, Somatic, and Psychosocial Factors in ADHD: A Nationwide Study

Brikell, I., Wimberley, T., Albiñana, C., Vilhjálmsson, B. J., Agerbo, E., Børglum, A. D., Demontis, D., Schork, A. J., LaBianca, S., Werge, T., Hougaard, D. M., Nordentoft, M., Mors, O., Mortensen, P. B., Petersen, L. V. & Dalsgaard, S., Jan 2023, In: The American Journal of Psychiatry (Spanish Edition). 180, 1, p. 73-88 16 p.

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6 Citations (Scopus)

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Levey, D. F., Galimberti, M., Deak, J. D., Wendt, F. R., Bhattacharya, A., Koller, D., Harrington, K. M., Quaden, R., Johnson, E. C., Gupta, P., Biradar, M., Lam, M., Cooke, M., Rajagopal, V. M., Empke, S. L. L., Zhou, H., Nunez, Y. Z., Kranzler, H. R., Edenberg, H. J. & Agrawal, A. & 11 others, Smoller, J. W., Lencz, T., Hougaard, D. M., Børglum, A. D., Demontis, D., Gaziano, J. M., Gandal, M. J., Polimanti, R., Stein, M. B., Gelernter, J. & Veterans Affairs Million Veteran Program, Dec 2023, In: Nature Genetics. 55, 12, p. 2094-2103 10 p.

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36 Citations (Scopus)

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Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Zhou, H., Kember, R. L., Deak, J. D., Xu, H., Toikumo, S., Yuan, K., Lind, P. A., Farajzadeh, L., Wang, L., Hatoum, A. S., Johnson, J., Lee, H., Mallard, T. T., Xu, J., Johnston, K. J. A., Johnson, E. C., Nielsen, T. T., Galimberti, M., Dao, C. & Levey, D. F. & 30 others, Overstreet, C., Byrne, E. M., Gillespie, N. A., Gordon, S., Hickie, I. B., Whitfield, J. B., Xu, K., Zhao, H., Huckins, L. M., Davis, L. K., Sanchez-Roige, S., Madden, P. A. F., Heath, A. C., Medland, S. E., Martin, N. G., Ge, T., Smoller, J. W., Hougaard, D. M., Børglum, A. D., Demontis, D., Krystal, J. H., Gaziano, J. M., Edenberg, H. J., Agrawal, A., Zhao, H., Justice, A. C., Stein, M. B., Kranzler, H. R., Gelernter, J. & Million Veteran Program, Dec 2023, In: Nature Medicine. 29, 12, p. 3184-3192 9 p.

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40 Citations (Scopus)

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Transcriptomic risk scores for attention deficit/hyperactivity disorder

Cabana-Domínguez, J., Llonga, N., Arribas, L., Alemany, S., Vilar-Ribó, L., Demontis, D., Fadeuilhe, C., Corrales, M., Richarte, V., Børglum, A. D., Ramos-Quiroga, J. A., Soler Artigas, M. & Ribasés, M., Aug 2023, In: Molecular Psychiatry. 28, 8, p. 3493-3502 10 p.

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4 Citations (Scopus)

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Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Hsu, Y. H. H., Pintacuda, G., Liu, R., Nacu, E., Kim, A., Tsafou, K., Petrossian, N., Crotty, W., Suh, J. M., Riseman, J., Martin, J. M., Biagini, J. C., Mena, D., Ching, J. K. T., Malolepsza, E., Li, T., Singh, T., Ge, T., Egri, S. B. & Tanenbaum, B. & 6 others, Stanclift, C. R., Apffel, A. M., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium, 19 May 2023, In: iScience. 26, 5, 106701.

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2022

Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder

Rajagopal, V. M., Duan, J., Vilar-Ribó, L., Grove, J., Zayats, T., Ramos-Quiroga, J. A., Satterstrom, F. K., Artigas, M. S., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Als, T. D., Rosengren, A., Daly, M. J., Neale, B. M., Nordentoft, M., Werge, T., Mors, O., Hougaard, D. M., Mortensen, P. B. & Ribasés, M. & 2 others, Børglum, A. D. & Demontis, D., Aug 2022, In: Nature Genetics. 54, 8, p. 1117-1124 8 p.

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35 Citations (Scopus)

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins, N., Kang, J., Campos, A., Coleman, J. R., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M.-H., Watson, H. J., Adams, M., Awasthi, S., Ganda, M., Hafferty, J. D., Hishimoto, A., Kim, M., Okazaki, S. & Otsuka, I. & 30 others, Ripke, S., Ware, E. B., Bergen, A. W., Berrettini, W. H., Bohus, M., Brandt, H., Chang, X., Chen, W. J., Chen, H.-C., Crawford, S., Crow, S., DiBlasi, E., Duriez, P., Fernandez-Aranda, F., Fichter, M. M., Gallinger, S., Glatt, S. J., Gorwood, P., Guo, Y., Hakonarson, H., Halmi, K. A., Yilmaz, Z., Byrne, E. M., Mortensen, P. B., Sonuga-Barke, E. J. S., Vilar-Ribo, L., Psychiat Genomics Consortium, German Borderline Genomics Consort, MVP Suicide Exemplar Workgrp & VA Million Vet Program, Feb 2022, In: Biological Psychiatry. 91, 3, p. 313-327 15 p.

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151 Citations (Scopus)

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Drug repurposing candidates to treat core symptoms in autism spectrum disorder

Koch, E. & Demontis, D., Sept 2022, In: Frontiers in Pharmacology. 13, 995439.

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Open Access

10 Citations (Scopus)

Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

Eising, E., Mirza-Schreiber, N., de Zeeuw, E. L., Wang, C. A., Truong, D. T., Allegrini, A. G., Shapland, C. Y., Zhu, G., Wigg, K. G., Gerritse, M. L., Molz, B., Alagoz, G., Gialluisi, A., Abbondanza, F., Rimfeld, K., van Donkelaar, M., Liao, Z., Jansen, P. R., Andlauer, T. F. M. & Bates, T. C. & 75 others, Bernard, M., Blokland, K., Bonte, M., Børglum, A. D., Bourgeron, T., Brandeis, D., Ceroni, F., Csepe, V., Dale, P. S., de Jong, P. F., DeFries, J. C., Demonet, J. F., Demontis, D., Feng, Y., Gordon, S. D., Guger, S. L., Hayiou-Thomas, M. E., Hernandez-Cabrera, J. A., Hottenga, J. J., Hulme, C., Kere, J., Kerr, E. N., Koomar, T., Landerl, K., Leonard, G. T., Lovett, M. W., Lyytinen, H., Martin, N. G., Martinelli, A., Maurer, U., Michaelson, J. J., Moll, K., Monaco, A. P., Morgan, A. T., Nothen, M. M., Pausova, Z., Pennell, C. E., Pennington, B. F., Price, K. M., Rajagopal, V. M., Ramus, F., Richer, L., Simpson, N. H., Smith, S. D., Snowling, M. J., Stein, J., Strug, L. J., Talcott, J. B., Tiemeier, H., van der Schroeff, M. P., Verhoef, E., Watkins, K. E., Wilkinson, M., Wright, M. J., Barr, C. L., Boomsma, D. I., Carreiras, M., Franken, M. C. J., Gruen, J. R., Luciano, M., Muller-Myhsok, B., Newbury, D. F., Olson, R. K., Paracchini, S., Paus, T., Plomin, R., Reilly, S., Schulte-Korne, G., Bruce Tomblin, J., van Bergen, E., Whitehouse, A. J. O., Willcutt, E. G., Pourcain, B. S., Francks, C. & Fisher, S. E., Aug 2022, In: Proceedings of the National Academy of Sciences (PNAS). 119, 35, e2202764119.

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55 Citations (Scopus)

37 Downloads (Pure)

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

Mattheisen, M., Grove, J., Als, T. D., Martin, J., Voloudakis, G., Meier, S., Demontis, D., Bendl, J., Walters, R., Carey, C. E., Rosengren, A., Strom, N. I., Hauberg, M. E., Zeng, B., Hoffman, G., Zhang, W., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Agerbo, E. & Cormand, B. & 14 others, Nordentoft, M., Werge, T., Mors, O., Hougaard, D. M., Buxbaum, J. D., Faraone, S. V., Franke, B., Dalsgaard, S., Mortensen, P. B., Robinson, E. B., Roussos, P., Neale, B. M., Daly, M. J. & Børglum, A. D., Oct 2022, In: Nature Genetics. 54, 10, p. 1470-1478 9 p.

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41 Citations (Scopus)

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Trubetskoy, V., Pardiñas, A. F., Qi, T., Panagiotaropoulou, G., Awasthi, S., Bigdeli, T. B., Bryois, J., Chen, C.-Y., Dennison, C. A., Hall, L. S., Lam, M., Watanabe, K., Frei, O., Ge, T., Harwood, J. C., Koopmans, F., Magnusson, S., Richards, A. L., Sidorenko, J. & Wu, Y. & 31 others, Zeng, J., Grove, J., Kim, M., Li, Z., Voloudakis, G., Zhang, W., Adams, M., Agartz, I., Atkinson, E. G., Agerbo, E., Al Eissa, M., Albus, M., Alexander, M., Alizadeh, B. Z., Alptekin, K., Als, T. D., Amin, F., Arolt, V., Arrojo, M., Athanasiu, L., Azevedo, M. H., Demontis, D., Mattheisen, M., McGrath, J. J., Meier, S., Chen, W. J., Mors, O., Mortensen, P. B., Børglum, A. D., Yang, J. & Indonesia Schizophrenia Consortium, 21 Apr 2022, In: Nature. 604, 7906, p. 502-508 7 p.

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1340 Citations (Scopus)

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Blokland, G. A. M., Grove, J., Chen, C. Y., Cotsapas, C., Tobet, S., Handa, R., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH, Jan 2022, In: Biological Psychiatry. 91, 1, p. 102-117 16 p.

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69 Citations (Scopus)

Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample

Moses, M., Tiego, J., Demontis, D., Bragi Walters, G., Stefansson, H., Stefansson, K., Børglum, A. D., Arnatkeviciute, A. & Bellgrove, M. A., Dec 2022, In: Molecular Psychiatry. 27, 12, p. 5028-5037 10 p.

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16 Citations (Scopus)

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2021

Author Correction: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder (Nature communications (2021) 12 1 (576))

Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasés, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Werge, T., Nordentoft, M., Mors, O., Mortensen, P. B., ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Cormand, B., Hougaard, D. M., Neale, B. M., Franke, B. & Faraone, S. V. & 1 others, Børglum, A. D., 1 Dec 2021, In: Nature Communications. 12, 1 p., 1166.

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1 Citation (Scopus)

Correction to: Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality

ADHD Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Jul 2021, In: Molecular Psychiatry. 26, 7, p. 3663 1 p.

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4 Citations (Scopus)

Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy

Verhoef, E., Grove, J., Shapland, C. Y., Demontis, D., Burgess, S., Rai, D., Børglum, A. D. & St Pourcain, B., Nov 2021, In: Nature Communications. 12, 6534.

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7 Citations (Scopus)

Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits

Martin, J., Khramtsova, E. A., Goleva, S. B., Blokland, G. A. M., Traglia, M., Walters, R. K., Hübel, C., Coleman, J. R. I., Breen, G., Børglum, A. D., Demontis, D., Grove, J., Werge, T., Bralten, J., Bulik, C. M., Lee, P. H., Mathews, C. A., Peterson, R. E., Winham, S. J. & Wray, N. & 13 others, Edenberg, H. J., Guo, W., Yao, Y., Neale, B. M., Faraone, S. V., Petryshen, T. L., Weiss, L. A., Duncan, L. E., Goldstein, J. M., Smoller, J. W., Stranger, B. E., Davis, L. K. & Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, Jun 2021, In: Biological Psychiatry. 89, 12, p. 1127-1137 11 p.

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46 Citations (Scopus)

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Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD

Brikell, I., Wimberley, T., Albiñana, C., Pedersen, E. M., Vilhjálmsson, B. J., Agerbo, E., Demontis, D., Børglum, A. D., Schork, A. J., LaBianca, S., Werge, T., Mors, O., Hougaard, D. M., Thapar, A., Mortensen, P. B. & Dalsgaard, S., Sept 2021, In: American Journal of Psychiatry. 178, 9, p. 854-864 11 p.

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18 Citations (Scopus)

116 Downloads (Pure)

Identification of genetic loci associated with nocturnal enuresis: a genome-wide association study

Jørgensen, C. S., Horsdal, H. T., Rajagopal, V. M., Grove, J., Als, T. D., Kamperis, K., Nyegaard, M., Walters, G. B., Eðvarðsson, V. Ö., Stefánsson, H., Nordentoft, M., Hougaard, D. M., Werge, T., Mors, O., Mortensen, P. B., Agerbo, E., Rittig, S., Stefánsson, K., Børglum, A. D. & Demontis, D. & 1 others, Christensen, J. H., Mar 2021, In: The Lancet Child and Adolescent Health. 5, 3, p. 201-209 9 p.

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38 Citations (Scopus)

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

Treur, J. L., Demontis, D., Smith, G. D., Sallis, H., Richardson, T. G., Wiers, R. W., Børglum, A. D., Verweij, K. J. H. & Munafò, M. R., Jan 2021, In: Addiction Biology. 26, 1, 11 p., e12849.

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66 Citations (Scopus)

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Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasas, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Werge, T., Nordentoft, M., Mors, O., Mortensen, P. B., ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Cormand, B., Hougaard, D. M., Neale, B. M., Franke, B. & Faraone, S. V. & 1 others, Børglum, A. D., 1 Dec 2021, In: Nature Communications. 12, 1, 12 p., 576.

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35 Citations (Scopus)

Role of DNA Methylation in Mediating Genetic Risk of Psychiatric Disorders

Starnawska, A. & Demontis, D., 1 Apr 2021, In: Frontiers in Psychiatry. 12, 596821.

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20 Citations (Scopus)

2020

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Johnson, E. C., Demontis, D., Thorgeirsson, T. E., Walters, R. K., Polimanti, R., Hatoum, A. S., Sanchez-Roige, S., Paul, S. E., Wendt, F. R., Clarke, T.-K., Lai, D., Reginsson, G. W., Zhou, H., He, J., Baranger, D. A. A., Gudbjartsson, D. F., Wedow, R., Adkins, D. E., Adkins, A. E. & Alexander, J. & 31 others, Bacanu, S.-A., Bigdeli, T. B., Boden, J., Brown, S. A., Bucholz, K. K., Bybjerg-Grauholm, J., Corley, R. P., Degenhardt, L., Dick, D. M., Domingue, B. W., Fox, L., Goate, A. M., Gordon, S. D., Hack, L. M., Hancock, D. B., Hartz, S. M., Hickie, I. B., Hougaard, D. M., Krauter, K., Lind, P. A., McClintick, J. N., McQueen, M. B., Meyers, J. L., Montgomery, G. W., Mors, O., Mortensen, P. B., Nordentoft, M., Pearson, J. F., Peterson, R. E., Børglum, A. D. & Psychiatric Genomics Consortium Substance Use Disorders Workgroup, 1 Dec 2020, In: The Lancet Psychiatry. 7, 12, p. 1032-1045 14 p.

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199 Citations (Scopus)

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Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality

Soler Artigas, M., Sánchez-Mora, C., Rovira, P., Richarte, V., Garcia-Martínez, I., Pagerols, M., Demontis, D., Stringer, S., Vink, J. M., Børglum, A. D., Neale, B. M., Franke, B., Faraone, S. V., Casas, M., Ramos-Quiroga, J. A., Ribasés, M., ADHD Group of the Psychiatric Genomics Consortium, International Cannabis Consortium & International Cannabis Consortium, 1 Oct 2020, In: Molecular Psychiatry. 25, 10, p. 2493-2503 11 p.

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60 Citations (Scopus)

Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in Drosophila

Klein, M., Singgih, E. L., van Rens, A., Demontis, D., Børglum, A. D., Mota, N. R., Castells-Nobau, A., Kiemeney, L. A., Brunner, H. G., Arias-Vasquez, A., Schenck, A., van der Voet, M. & Franke, B., Jun 2020, In: The American Journal of Psychiatry. 177, 6, p. 526-536 11 p.

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21 Citations (Scopus)

Genetic liability to ADHD and substance use disorders in individuals with ADHD

Wimberley, T., Agerbo, E., Horsdal, H. T., Ottosen, C., Brikell, I., Als, T. D., Demontis, D., Børglum, A. D., Nordentoft, M., Mors, O., Werge, T., Hougaard, D., Bybjerg-Grauholm, J., Hansen, M. B., Mortensen, P. B., Thapar, A., Riglin, L., Langley, K. & Dalsgaard, S., Jul 2020, In: Addiction. 115, 7, p. 1368-1377 10 p.

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46 Citations (Scopus)

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Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples

Esteller-Cucala, P., Maceda, I., Børglum, A. D., Demontis, D., Faraone, S. V., Cormand, B. & Lao, O., May 2020, In: Scientific Reports. 10, 8622.

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20 Citations (Scopus)

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

Satterstrom, F. K., Kosmicki, J. A., Wang, J., Breen, M. S., De Rubeis, S., An, J. Y., Peng, M., Collins, R., Grove, J., Klei, L., Stevens, C., Reichert, J., Mulhern, M. S., Artomov, M., Gerges, S., Sheppard, B., Xu, X., Bhaduri, A., Norman, U. & Brand, H. & 7 others, Schwartz, G., Nguyen, R., Guerrero, E. E., Dias, C., Autism Sequencing Consortium, iPSYCH-Broad Consortium & Børglum, A. D., Feb 2020, In: Cell. 180, 3, p. 568-584.e23

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1348 Citations (Scopus)

Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder

Østergaard, S. D., Trabjerg, B. B., Als, T. D., Albiñana, C., Privé, F., Vilhjálmsson, B. J., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Nordentoft, M., Werge, T., Demontis, D., Mortensen, P. B., Børglum, A. D., Mors, O. & Agerbo, E., 1 Dec 2020, In: Translational Psychiatry. 10, 1, 11 p., 335.

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23 Citations (Scopus)

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Rovira, P., Demontis, D., Sánchez-Mora, C., Zayats, T., Klein, M., Mota, N. R., Weber, H., Garcia-Martínez, I., Pagerols, M., Vilar-Ribó, L., Arribas, L., Richarte, V., Corrales, M., Fadeuilhe, C., Bosch, R., Martin, G. E., Almos, P., Doyle, A. E., Grevet, E. H. & Grimm, O. & 32 others, Halmøy, A., Hoogman, M., Hutz, M., Jacob, C. P., Kittel-Schneider, S., Knappskog, P. M., Lundervold, A. J., Rivero, O., Rovaris, D. L., Salatino-Oliveira, A., da Silva, B. S., Svirin, E., Sprooten, E., Strekalova, T., Arias-Vasquez, A., Sonuga-Barke, E. J. S., Asherson, P., Bau, C. H. D., Buitelaar, J. K., Cormand, B., Faraone, S. V., Haavik, J., Johansson, S. E., Kuntsi, J., Larsson, H., Lesch, K. P., Reif, A., Rohde, L. A., Casas, M., Børglum, A. D., ADHD Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, 1 Sept 2020, In: Neuropsychopharmacology. 45, 10, p. 1617-1626 10 p.

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2019

Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

Satterstrom, F. K., Walters, R. K., Singh, T., Wigdor, E. M., Lescai, F., Demontis, D., Kosmicki, J. A., Grove, J., Stevens, C., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Palmer, D. S., Maller, J. B., iPSYCH-Broad Consortium, Nordentoft, M., Mors, O., Robinson, E. B., Hougaard, D. M., Werge, T. M. & Bo Mortensen, P. & 3 others, Neale, B. M., Børglum, A. D. & Daly, M. J., Dec 2019, In: Nature Neuroscience. 22, 12, p. 1961-1965 5 p.

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131 Citations (Scopus)

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Demontis, D., Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., Belliveau, R., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Cerrato, F., Chambert, K., Churchhouse, C., Dumont, A., Eriksson, N., Gandal, M., Goldstein, J. I., Grasby, K. L., Grove, J. & Gudmundsson, O. O. & 31 others, Hansen, C. S., Hauberg, M. E., Hollegaard, M. V., Howrigan, D. P., Huang, H., Maller, J. B., Martin, A. R., Martin, N. G., Moran, J., Pallesen, J., Palmer, D. S., Pedersen, C. B., Pedersen, M. G., Poterba, T., Poulsen, J. B., Ripke, S., Robinson, E. B., Satterstrom, F. K., Stefansson, H., Stevens, C., Turley, P., Walters, G. B., Won, H., Wright, M. J., ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Dalsgaard, S., Mors, O., Mortensen, P. B. & Børglum, A. D., 1 Jan 2019, In: Nature Genetics. 51, 1, p. 63–75 13 p.

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1420 Citations (Scopus)

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Ditte Demontis

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