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Daniel Otzen

Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides

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Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena : the all-pervading powers of flavonoids and phenolic glycosides. / Eskandari, Hoda; Ghanadian, Mustafa; Noleto-Dias, Clarice et al.

In: ACS Chemical Neuroscience, Vol. 11, No. 19, 10.2020, p. 3161–3173.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Eskandari, H, Ghanadian, M, Noleto-Dias, C, Lomax, C, Tawfike, A, Christiansen, G, Sutherland, DS, Ward, JL, Mohammad-Beigi, H & Otzen, DE 2020, 'Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides', ACS Chemical Neuroscience, vol. 11, no. 19, pp. 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528

APA

Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H., & Otzen, D. E. (2020). Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience, 11(19), 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528

CBE

MLA

Vancouver

Eskandari H, Ghanadian M, Noleto-Dias C, Lomax C, Tawfike A, Christiansen G et al. Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience. 2020 Oct;11(19):3161–3173. Epub 2020 Sep 4. doi: 10.1021/acschemneuro.0c00528

Author

Eskandari, Hoda ; Ghanadian, Mustafa ; Noleto-Dias, Clarice et al. / Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena : the all-pervading powers of flavonoids and phenolic glycosides. In: ACS Chemical Neuroscience. 2020 ; Vol. 11, No. 19. pp. 3161–3173.

Bibtex

@article{eca8a09bc2574d1398dfbacc27076623,
title = "Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides",
abstract = "There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation of α-Synuclein (α-Syn), whose aggregation is key to the development of Parkinson's disease (PD). Rosa damascena is a medicinal herb widely used in Middle Eastern food, ceremonies, and perfumes. The herb is known to contain many different polyphenols. Here we investigated the existence of α-Syn fibrillation inhibitors in R. damascena extract. Different HPLC fractions of the extract were assessed in α-Syn fibrillation and toxicity assays. The most active fractions led to the formation of more α-Syn oligomers but with less toxicity to SH-SY5Y cells, according to MTT and LDH assays. LC-MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-β-rutinoside, and quercetin which were subsequently shown to be strong α-Syn fibrillation inhibitors. Our results highlight the benefits of R. damascena extract to combat PD at the population level.",
author = "Hoda Eskandari and Mustafa Ghanadian and Clarice Noleto-Dias and Charlotte Lomax and Ahmed Tawfike and Gunna Christiansen and Sutherland, {Duncan S} and Ward, {Jane L} and Hossein Mohammad-Beigi and Otzen, {Daniel Erik}",
year = "2020",
month = oct,
doi = "10.1021/acschemneuro.0c00528",
language = "English",
volume = "11",
pages = "3161–3173",
journal = "A C S Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "19",

}

RIS

TY - JOUR

T1 - Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena

T2 - the all-pervading powers of flavonoids and phenolic glycosides

AU - Eskandari, Hoda

AU - Ghanadian, Mustafa

AU - Noleto-Dias, Clarice

AU - Lomax, Charlotte

AU - Tawfike, Ahmed

AU - Christiansen, Gunna

AU - Sutherland, Duncan S

AU - Ward, Jane L

AU - Mohammad-Beigi, Hossein

AU - Otzen, Daniel Erik

PY - 2020/10

Y1 - 2020/10

N2 - There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation of α-Synuclein (α-Syn), whose aggregation is key to the development of Parkinson's disease (PD). Rosa damascena is a medicinal herb widely used in Middle Eastern food, ceremonies, and perfumes. The herb is known to contain many different polyphenols. Here we investigated the existence of α-Syn fibrillation inhibitors in R. damascena extract. Different HPLC fractions of the extract were assessed in α-Syn fibrillation and toxicity assays. The most active fractions led to the formation of more α-Syn oligomers but with less toxicity to SH-SY5Y cells, according to MTT and LDH assays. LC-MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-β-rutinoside, and quercetin which were subsequently shown to be strong α-Syn fibrillation inhibitors. Our results highlight the benefits of R. damascena extract to combat PD at the population level.

AB - There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation of α-Synuclein (α-Syn), whose aggregation is key to the development of Parkinson's disease (PD). Rosa damascena is a medicinal herb widely used in Middle Eastern food, ceremonies, and perfumes. The herb is known to contain many different polyphenols. Here we investigated the existence of α-Syn fibrillation inhibitors in R. damascena extract. Different HPLC fractions of the extract were assessed in α-Syn fibrillation and toxicity assays. The most active fractions led to the formation of more α-Syn oligomers but with less toxicity to SH-SY5Y cells, according to MTT and LDH assays. LC-MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-β-rutinoside, and quercetin which were subsequently shown to be strong α-Syn fibrillation inhibitors. Our results highlight the benefits of R. damascena extract to combat PD at the population level.

U2 - 10.1021/acschemneuro.0c00528

DO - 10.1021/acschemneuro.0c00528

M3 - Journal article

C2 - 32886481

VL - 11

SP - 3161

EP - 3173

JO - A C S Chemical Neuroscience

JF - A C S Chemical Neuroscience

SN - 1948-7193

IS - 19

ER -