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Daniel Otzen

Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11. / Kim, Jun-Young; Sahu, Srikanta; Yau, Yin-Hoe; Wang, Xu; Shochat, Susana Geifman; Nielsen, Per Halkjær; Dueholm, Morten Simonsen; Otzen, Daniel E; Lee, Jungyeol; Delos Santos, May Margarette Salido; Yam, Joey Kuok Hoong; Kang, Nam-Young; Park, Sung-Jin; Kwon, Hawyoung; Seviour, Thomas William; Yang, Liang; Givskov, Michael; Chang, Young-Tae.

In: Journal of the American Chemical Society, 2016, p. 402-407.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Kim, J-Y, Sahu, S, Yau, Y-H, Wang, X, Shochat, SG, Nielsen, PH, Dueholm, MS, Otzen, DE, Lee, J, Delos Santos, MMS, Yam, JKH, Kang, N-Y, Park, S-J, Kwon, H, Seviour, TW, Yang, L, Givskov, M & Chang, Y-T 2016, 'Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11', Journal of the American Chemical Society, pp. 402-407. https://doi.org/10.1021/jacs.5b11357

APA

Kim, J-Y., Sahu, S., Yau, Y-H., Wang, X., Shochat, S. G., Nielsen, P. H., Dueholm, M. S., Otzen, D. E., Lee, J., Delos Santos, M. M. S., Yam, J. K. H., Kang, N-Y., Park, S-J., Kwon, H., Seviour, T. W., Yang, L., Givskov, M., & Chang, Y-T. (2016). Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11. Journal of the American Chemical Society, 402-407. https://doi.org/10.1021/jacs.5b11357

CBE

Kim J-Y, Sahu S, Yau Y-H, Wang X, Shochat SG, Nielsen PH, Dueholm MS, Otzen DE, Lee J, Delos Santos MMS, Yam JKH, Kang N-Y, Park S-J, Kwon H, Seviour TW, Yang L, Givskov M, Chang Y-T. 2016. Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11. Journal of the American Chemical Society. 402-407. https://doi.org/10.1021/jacs.5b11357

MLA

Vancouver

Kim J-Y, Sahu S, Yau Y-H, Wang X, Shochat SG, Nielsen PH et al. Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11. Journal of the American Chemical Society. 2016;402-407. https://doi.org/10.1021/jacs.5b11357

Author

Kim, Jun-Young ; Sahu, Srikanta ; Yau, Yin-Hoe ; Wang, Xu ; Shochat, Susana Geifman ; Nielsen, Per Halkjær ; Dueholm, Morten Simonsen ; Otzen, Daniel E ; Lee, Jungyeol ; Delos Santos, May Margarette Salido ; Yam, Joey Kuok Hoong ; Kang, Nam-Young ; Park, Sung-Jin ; Kwon, Hawyoung ; Seviour, Thomas William ; Yang, Liang ; Givskov, Michael ; Chang, Young-Tae. / Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11. In: Journal of the American Chemical Society. 2016 ; pp. 402-407.

Bibtex

@article{280b687d51cf4faaa8022f385200af76,
title = "Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11",
abstract = "Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods which fail to detect non-culturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (Compound of Designation Yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a Diversity Oriented Fluorescent Library Approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.",
author = "Jun-Young Kim and Srikanta Sahu and Yin-Hoe Yau and Xu Wang and Shochat, {Susana Geifman} and Nielsen, {Per Halkj{\ae}r} and Dueholm, {Morten Simonsen} and Otzen, {Daniel E} and Jungyeol Lee and {Delos Santos}, {May Margarette Salido} and Yam, {Joey Kuok Hoong} and Nam-Young Kang and Sung-Jin Park and Hawyoung Kwon and Seviour, {Thomas William} and Liang Yang and Michael Givskov and Young-Tae Chang",
year = "2016",
doi = "10.1021/jacs.5b11357",
language = "English",
pages = "402--407",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "ACS Publications",

}

RIS

TY - JOUR

T1 - Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11

AU - Kim, Jun-Young

AU - Sahu, Srikanta

AU - Yau, Yin-Hoe

AU - Wang, Xu

AU - Shochat, Susana Geifman

AU - Nielsen, Per Halkjær

AU - Dueholm, Morten Simonsen

AU - Otzen, Daniel E

AU - Lee, Jungyeol

AU - Delos Santos, May Margarette Salido

AU - Yam, Joey Kuok Hoong

AU - Kang, Nam-Young

AU - Park, Sung-Jin

AU - Kwon, Hawyoung

AU - Seviour, Thomas William

AU - Yang, Liang

AU - Givskov, Michael

AU - Chang, Young-Tae

PY - 2016

Y1 - 2016

N2 - Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods which fail to detect non-culturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (Compound of Designation Yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a Diversity Oriented Fluorescent Library Approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.

AB - Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods which fail to detect non-culturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (Compound of Designation Yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a Diversity Oriented Fluorescent Library Approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.

U2 - 10.1021/jacs.5b11357

DO - 10.1021/jacs.5b11357

M3 - Journal article

C2 - 26684612

SP - 402

EP - 407

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

ER -