Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions
Somavarapu, A. K., Kleijwegt, G., Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E., Mar 2023, In: Chemical Science. 14, 11, p. 3030-3047 18 p.The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity
Pirhaghi, M., Najarzadeh, Z., Moosavi-Movahedi, F., Shafizadeh, M., Mamashli, F., Atarod, D., Ghasemi, A., Morshedi, D., Meratan, A. A., Otzen, D. E. & Saboury, A. A., Feb 2023, In: B B A - Proteins and Proteomics. 1871, 2, p. 140883 140883.The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells
Hourfar, H., Aliakbari, F., Aqdam, S. R., Nayeri, Z., Bardania, H., Otzen, D. E. & Morshedi, D., Feb 2023, In: International Journal of Biological Macromolecules. 229, p. 305-320 16 p.FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC
Rasmussen, H. Ø., Kumar, A., Shin, B., Stylianou, F., Sewell, L., Xu, Y., Otzen, D. E., Pedersen, J. S. & Matthews, S. J., Jan 2023, In: Journal of Molecular Biology. 435, 2, 18 p., 167878.Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation
Alijanvand, S. H., Ladefoged, L. K., Zubrienė, A., Sakalauskas, A., Christiansen, G., Dudutiene, V., Schiøtt, B., Matulis, D., Smirnovas, V. & Otzen, D. E., 2023, In: International Journal of Biological Macromolecules. 227, p. 590-600 11 p.A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL
Kjærgaard, M., Rasmussen, L. S., Vinther, J. N., Andersen, K. R., Andersen, E. S., Lorentzen, E., Thirup, S. S., Otzen, D. & Brodersen, D. E., Dec 2022, In: The Biophysicist. 3, 2, p. 106–114 9 p.A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaite, V., Gupta, A., Strømgaard, K., Andreasen, M., Sharma, D., Saboury, A. A. & Otzen, D. E., Dec 2022, In: Journal of Biological Chemistry. 298, 12, 102688.Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
He, J., Steffen, J. H., Thulstrup, P. W., Pedersen, J. N., Sauerland, M. B., Otzen, D. E., Hawkins, C. L., Gourdon, P., Davies, M. J. & Hägglund, P., Dec 2022, In: Scientific Reports. 12, 1, 15 p., 22051.EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers
Grønnemose, A. L., Østerlund, E. C., Otzen, D. E. & Jørgensen, T. J. D., Dec 2022, In: Journal of Molecular Biology. 434, 23, 167855.Functional amyloid in a lipid-like environment: a merry dance of many steps
Otzen, D. E., Dec 2022, In: Essays in Biochemistry. 66, 7Molecular-level insights into the surface-induced assembly of Functional Bacterial Amyloid
Sønderby, T. V., Zou, Y., Wang, P., Wang, C. & Otzen, D. E., Sept 2022, In: Biophysical Journal. 121, 18, p. 3422-3434 13 p.Uncovering the universality of self-replication in protein aggregation and its link to disease
Meisl, G., Xu, C. K., Taylor, J. D., Michaels, T. C. T., Levin, A., Otzen, D., Klenerman, D., Matthews, S., Linse, S., Andreasen, M. & Knowles, T. P. J., Aug 2022, In: Science Advances. 8, 32, eabn6831.Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization
Sahin, C., Østerlund, E. C., Österlund, N., Costeira-Paulo, J., Pedersen, J. N., Christiansen, G., Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, M. J., Ilag, L. L., Davies, M. J., Marklund, E. G., Pedersen, J. S., Landreh, M., Møller, I. M., Jørgensen, T. J. D. & Otzen, D. E., Jul 2022, In: Journal of the American Chemical Society. 144, 27, p. 11949-11954 6 p.Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response
Bisiak, F., Chrenková, A., Zhang, S. D., Pedersen, J. N., Otzen, D. E., Zhang, Y. E. & Brodersen, D. E., Jul 2022, In: Journal of Biological Chemistry. 298, 7, 102142.The optimal docking strength for reversibly tethered kinases
Dyla, M., González Foutel, N. S., Otzen, D. E. & Kjaergaard, M., 21 Jun 2022, In: Proceedings of the National Academy of Sciences. 119, 25, e2203098119.Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition
Farzadfard, A., König, A., Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F. & Otzen, D. E., May 2022, In: The Journal of Biological Chemistry. 298, 5, 14 p., 101848.The changing face of SDS denaturation: Complexes of Thermomyces lanuginosus lipase with SDS at pH 4.0, 6.0 and 8.0
Rasmussen, H. Ø., Wollenberg, D. T. W., Wang, H., Andersen, K. K., Oliveira, C. L. P., Jørgensen, C. I., Jørgensen, T. J. D., Otzen, D. E. & Pedersen, J. S., May 2022, In: Journal of Colloid and Interface Science. 614, p. 214-232 19 p.Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein
Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J-Y. & Jensen, P. H., Mar 2022, In: Scientific Reports. 12, 3737.Bidirectional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners
Christensen, N. R., Pedersen, C. P., Sereikaite, V., Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T., Otzen, D., Teilum, K., Madsen, K. L. & Strømgaard, K., Feb 2022, In: iScience. 25, 2, 26 p., 103808.Induction, inhibition, and incorporation: Different roles for anionic and zwitterionic lysolipids in the fibrillation of the functional amyloid FapC
Rasmussen, H. Ø., Otzen, D. E. & Pedersen, J. S., Feb 2022, In: The Journal of Biological Chemistry. 298, 2, 50 p., 101569.The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
Farzadfard, A., Pedersen, J. N., Meisl, G., Somavarapu, A. K., Alam, P., Goksøyr, L., Nielsen, M. A., Sander, A. F., Knowles, T. P. J., Pedersen, J. S. & Otzen, D. E., Feb 2022, In: Communications Biology. 5, 1, 10 p., 123.A Protein Corona Modulates Interactions of α-Synuclein with Nanoparticles and Alters the Rates of the Microscopic Steps of Amyloid Formation
Mohammad-Beigi, H., Zanganeh, M., Scavenius, C., Eskandari, H., Farzadfard, A., Shojaosadati, S. A., Enghild, J. J., Otzen, D. E., Buell, A. K. & Sutherland, D. S., Jan 2022, In: ACS Nano. 16, 1, p. 1102-1118 17 p.Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation
Nagaraj, M., Najarzadeh, Z., Pansieri, J., Biverstål, H., Musteikyte, G., Smirnovas, V., Matthews, S., Emanuelsson, C., Johansson, J., Buxbaum, J. N., Morozova-Roche, L. & Otzen, D. E., Jan 2022, In: Chemical Science. 13, 2, p. 536-553 18 p.Folding steps in the fibrillation of functional amyloid: denaturant sensitivity reveals common features in nucleation and elongation
Sønderby, T. V., Rasmussen, H. Ø., Frank, S. A., Skov Pedersen, J. & Otzen, D. E., Jan 2022, In: Journal of Molecular Biology. 434, 2, 18 p., 167337.Characterization of exogenous αSN response genes and their relation to Parkinson's disease using network analyses
Nayeri, Z., Aliakbari, F., Afzali, F., Parsafar, S., Gharib, E., Otzen, D. E. & Morshedi, D., 2022, In: Frontiers in Pharmacology. 13, 14 p., 966760.Interaction of membrane vesicles with the
Pseudomonas functional amyloid protein FapC facilitates amyloid formation.
Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Pedersen, J. S., Nielsen, J. & Otzen, D. E., 2022, In: BBA advances. 2, p. 100055Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers
Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S., 2022, In: Fluids and Barriers of the CNS. 19, 1, 12 p., 37.A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces
Choong, F. X., Huzell, S., Rosenberg, M., Eckert, J. A., Nagaraj, M., Zhang, T., Melican, K., Otzen, D. E. & Richter-Dahlfors, A., Dec 2021, In: Biofilm. 3, 100060.Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications
Andersen, C., Grønnemose, A. L., Pedersen, J. N., Nowak, J. S., Christiansen, G., Nielsen, J., Mulder, F. A. A., Otzen, D. E. & Jørgensen, T. J. D., 30 Nov 2021, In: Biochemistry. 60, 47, p. 3644-3658 15 p.Adsorption of azo dyes by a novel bio-nanocomposite based on whey protein nanofibrils and nano-clay: Equilibrium isotherm and kinetic modeling
Rahimi Aqdam, S., Otzen, D. E., Mahmoodi, N. M. & Morshedi, D., Nov 2021, In: Journal of Colloid and Interface Science. 602, p. 490-503Membrane Structure of Aquaporin Observed with Combined Experimental and Theoretical Sum Frequency Generation Spectroscopy
Schmüser, L., Trefz, M., Roeters, S. J., Beckner, W., Pfaendtner, J., Otzen, D., Woutersen, S., Bonn, M., Schneider, D. & Weidner, T., Nov 2021, In: Langmuir : the ACS journal of surfaces and colloids. 37, 45, p. 13452-13459 8 p.The bacterial amyloids phenol soluble modulins from staphylococcus aureus catalyze alpha-synuclein aggregation
Haikal, C., Pascual, L. O., Najarzadeh, Z., Bernfur, K., Svanbergsson, A., Otzen, D. E., Linse, S. & Li, J. Y., Nov 2021, In: International Journal of Molecular Sciences . 22, 21, 11594.Microfluidics and the quantification of biomolecular interactions
Otzen, D. E., Buell, A. K. & Jensen, H., Oct 2021, In: Current Opinion in Structural Biology. 70, p. 8-15 8 p.Cys-labelling kinetics of membrane protein GlpG: a role for specific SDS binding and micelle changes?
Otzen, D. E., Pedersen, J. N., Somavarapu, A. K., Clement, A., Ji, M., Petersen, E. H., Pedersen, J. S., Urban, S. & Schafer, N. P., Sept 2021, In: Biophysical Journal. 120, 18, p. 4115-4128Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats
Christensen, L. F. B., Alijanvand, S. H., Burdukiewicz, M., Herbst, F-A., Kjeldal, H., Dueholm, M. S. & Otzen, D. E., Sept 2021, In: Protein Science. 30, 9, p. 1854-1870Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus
Najarzadeh, Z., Zaman, M., Sereikaite, V., Strømgaard, K., Andreasen, M. & Otzen, D. E., Aug 2021, In: The Journal of Biological Chemistry. 297, 2, p. 100953 14 p.Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus
Najarzadeh, Z., Nielsen, J., Farzadfard, A., Sereikaite, V., Strømgaard, K., Meyer, R. L. & Otzen, D. E., Aug 2021, In: ACS Omega. 6, 34, p. 21960-21970 11 p.Ubiquitin forms conventional decorated micelle structures with sodium dodecyl sulfate at saturation
Mortensen, H. G., Otzen, D. E. & Pedersen, J. S., Aug 2021, In: Journal of Colloid and Interface Science. 596, p. 233-244 12 p.Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Ferreira, N., Gram, H., Sorrentino, Z. A., Gregersen, E., Schmidt, S. I., Reimer, L., Betzer, C., Perez-Gozalbo, C., Beltoja, M., Nagaraj, M., Wang, J., Nowak, J. S., Dong, M., Willén, K., Cholak, E., Bjerregaard-Andersen, K., Mendez, N., Rabadia, P., Shahnawaz, M., Soto, C., Otzen, D. E., Meyer, M., Giasson, B. I., Romero-Ramos, M. & Jensen, P. H., Jul 2021, In: Acta Neuropathologica. 142, p. 87-115Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity
Walther, R., Monge, P., Pedersen, A., Benderoth, A., Pedersen, J., Farzadfard, A., Mandrup, O., Howard, K., Otzen, D. & Zelikin, A. N., Jul 2021, In: ChemBioChem. 22, 14, p. 2478-2485 8 p.A multimethod approach for analyzing FapC fibrillation and determining mass per length
Rasmussen, H. Ø., Otzen, D. E. & Pedersen, J. S., 1 Jun 2021, In: Biophysical Journal. 120, 11, p. 2262-2275 14 p.In situ Sub-Cellular Identification of Functional Amyloids in Bacteria and Archaea by Infrared Nanospectroscopy
Otzen, D. E., Dueholm, M. S., Najarzadeh, Z., Knowles, T. P. J. & Ruggeri, F. S., Jun 2021, In: Small Methods. 5, 6, 10 p., 2001002.In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2
Milanetti, E., Miotto, M., Di Rienzo, L., Nagaraj, M., Monti, M., Golbek, T. W., Gosti, G., Roeters, S. J., Weidner, T., Otzen, D. E. & Ruocco, G., Jun 2021, In: Frontiers in Molecular Biosciences. 8, 11 p., 690655.C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition
Amodeo, G. F., Lee, B. Y., Krilyuk, N., Filice, C. T., Valyuk, D., Otzen, D. E., Noskov, S., Leonenko, Z. & Pavlov, E. V., Apr 2021, In: Scientific Reports. 11, 1, 10 p., 8744.Multiple Protective Roles of Nanoliposome-Incorporated Baicalein against Alpha-Synuclein Aggregates
Aliakbari, F., Mohammad-Beigi, H., Abbasi, S., Rezaei-Ghaleh, N., Lermyte, F., Parsafar, S., Becker, S., Tafreshi, A. P., O'Connor, P. B., Collingwood, J. F., Christiansen, G., Sutherland, D. S., Jensen, P. H., Morshedi, D. & Otzen, D. E., 10 Feb 2021, In: Advanced Functional Materials. 31, 7, 2007765.A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes
Otzen, D. E., Morshedi, D., Mohammad-Beigi, H. & Aliakbari, F., Feb 2021, In: Journal of Membrane Biology. 254, 1, p. 29-39Breakdown of supersaturation barrier links protein folding to amyloid formation
Noji, M., Samejima, T., Yamaguchi, K., So, M., Yuzu, K., Chatani, E., Akazawa-Ogawa, Y., Hagihara, Y., Kawata, Y., Ikenaka, K., Mochizuki, H., Kardos, J., Otzen, D. E., Bellotti, V., Buchner, J. & Goto, Y., Jan 2021, In: Communications Biology. 4, 1, 10 p., 120.Molecular characteristics of porcine alpha-synuclein splicing variants
Larsen, K., Bæk, R., Sahin, C., Kjær, L., Christiansen, G., Nielsen, J., Farajzadeh, L. & Otzen, D. E., Jan 2021, In: Biochimie. 180, p. 121-133 13 p.Driving forces in amyloidosis: How does a light chain make a heavy heart?
Otzen, D., 2021, In: The Journal of Biological Chemistry. 296, p. 100785 100785.How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein
Andersen, C. B., Yoshimura, Y., Nielsen, J., Otzen, D. E. & Mulder, F. A. A., 2021, In: The Journal of Biological Chemistry. 296, 10 p., 100788.Phenol-Soluble Modulins Modulate Persister Cell Formation in Staphylococcus aureus
Baldry, M., Bojer, M. S., Najarzadeh, Z., Vestergaard, M., Meyer, R. L., Otzen, D. E. & Ingmer, H., Nov 2020, In: Frontiers in Microbiology. 11, 573253.Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides
Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H. & Otzen, D. E., Oct 2020, In: ACS Chemical Neuroscience. 11, 19, p. 3161–3173DIBMA nanodiscs keep α-synuclein folded
Adão, R., Cruz, P. F., Vaz, D. C., Fonseca, F., Pedersen, J. N., Ferreira-da-Silva, F., Brito, R. M. M., Ramos, C. H. I., Otzen, D., Keller, S. & Bastos, M., Sept 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 9, 16 p., 183314.Peak Force Infrared - Kelvin Probe Force Microscopy
Jakob, D. S., Wang, H., Zeng, G., Otzen, D. E., Yan, Y. & Xu, X., Sept 2020, In: Angewandte Chemie International Edition. 59, 37, p. 16083-16090 8 p.Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin
He, J., Becares, E. R., Thulstrup, P. W., Gamon, L. F., Pedersen, J. N., Otzen, D., Gourdon, P., Davies, M. J. & Hägglund, P., Sept 2020, In: Redox Biology. 36, 101631.Quantitating denaturation by formic acid: Imperfect repeats are essential to the stability of the functional amyloid protein FapC
Christensen, L. F. B., Nowak, J. S., Sønderby, T. V., Frank, S. A. & Otzen, D. E., Sept 2020, In: The Journal of biological chemistry. 295, 37, p. 13031–13046 16 p.SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence
Krainer, G., Hartmann, A., Bogatyr, V., Nielsen, J., Schlierf, M. & Otzen, D. E., Sept 2020, In: Chemical Science. 11, 34, p. 9141-9153 13 p.Multi-Step Unfolding and Rearrangement of α-Lactalbumin by SDS Revealed by Stopped-Flow SAXS
Jensen, G. V., Pedersen, J. N., Otzen, D. E. & Pedersen, J. S., Jul 2020, In: Frontiers in Molecular Biosciences. 7, 125.The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization
Marvian, A. T., Aliakbari, F., Mohammad-Beigi, H., Ahmadi, Z. A., Mehrpouyan, S., Lermyte, F., Nasouti, M., Collingwood, J. F., Otzen, D. E. & Morshedi, D., Jul 2020, In: International Journal of Biological Macromolecules. 155, p. 543-550 8 p.Amyloid formation of α-synuclein based on the solubility- and supersaturation-dependent mechanism
Sawada, M., Yamaguchi, K., Hirano, M., Noji, M., So, M., Otzen, D. E., Kawata, Y. & Goto, Y., May 2020, In: Langmuir. 36, 17, p. 4671-4681Nanosilver Mitigates Biofilm Formation via FapC Amyloidosis Inhibition
Huma, Z-E., Javed, I., Zhang, Z., Bilal, H., Sun, Y., Hussain, S. Z., Davis, T. P., Otzen, D. E., Landersdorfer, C. B., Ding, F., Hussain, I. & Ke, P. C., May 2020, In: Small (Weinheim an der Bergstrasse, Germany). 16, 21, 10 p., 1906674.The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth
van Gils, J. H. M., van Dijk, E., Peduzzo, A., Hofmann, A., Vettore, N., Schützmann, M. P., Groth, G., Mouhib, H., Otzen, D. E., Buell, A. K. & Abeln, S., May 2020, In: PLOS Computational Biology. 16, 5, e1007767.Novel noscapine derivatives stabilize the native state of insulin against fibrillation
Alijanvand, S. H., Christensen, M. H., Christiansen, G., Harikandei, K. B., Salehi, P., Schiøtt, B., Moosavi-Movahedi, A. A. & Otzen, D. E., Mar 2020, In: International Journal of Biological Macromolecules. 147, p. 98-108 11 p.Unfolding and partial refolding of a cellulase from the SDS-denatured state: From β-sheet to α-helix and back
Rasmussen, H. Ø., Enghild, J. J., Otzen, D. E. & Pedersen, J. S., Jan 2020, In: B B A - General Subjects. 1864, 1, p. 129434 1-12 12 p., 129434.A complete picture of protein unfolding and refolding in surfactants
Pedersen, J. N., Lyngsø, J., Zinn, T., Otzen, D. & Pedersen, J. S., 2020, In: Chemical Science. 11, 3, p. 699-712 14 p.Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC
Javed, I., Zhang, Z., Adamcik, J., Andrikopoulos, N., Li, Y., Otzen, D. E., Lin, S., Mezzenga, R., Davis, T. P., Ding, F. & Ke, P. C., 2020, In: Advanced Science. 7, 18, 15 p., 2001299.Amyloid fibril inhibition, acceleration, or fragmentation: Are nano-based approaches advance in the right direction?
Hajipour, M. J., Mohammad-Beigi, H., Nabipour, I., Mahmoudi, N., Azhdarzadeh, M., Derakhshankhah, H., El Dawud, D., Mohammadinejad, R. & Otzen, D., 2020, In: Nano Today. 35, December, 5 p., 100983.Predicted Loop Regions Promote Aggregation: A Study of Amyloidogenic Domains in the Functional Amyloid FapC
Nagaraj, M., Ahmed, M., Lyngsø, J., Vad, B. S., Bøggild, A., Fillipsen, A., Pedersen, J. S., Otzen, D. E. & Akbey, Ü., 2020, In: Journal of Molecular Biology. 432, 7, p. 2232-2252 21 p.Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4
Juul-Madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B., Howard, K., Dehesa-Etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-Ramos, M. & Vorup-Jensen, T., 2020, In: Journal of Immunology. 204, 5, p. 1345-1361 17 p.The interactome of stabilized α-synuclein oligomers and neuronal proteins
van Diggelen, F., Frank, S. A., Somavarapu, A. K., Scavenius, C., Apetri, M. M., Nielsen, J., Tepper, A. W. J. W., Enghild, J. J. & Otzen, D. E., 2020, In: The FEBS Journal. 287, 10, p. 2037-2054 18 p.Bacterial amphiphiles as amyloid inducers: Effect of Rhamnolipid and Lipopolysaccharide on FapC fibrillation
Najarzadeh, Z., Pedersen, J. N., Christiansen, G., Shojaosadati, S. A., Pedersen, J. S. & Otzen, D. E., 1 Nov 2019, In: B B A - Proteins and Proteomics. 1867, 11, 140263.Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers
Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Sønderby, T. V., Shojaosadati, S. A., Morshedi, D., Strømgaard, K., Meisl, G., Sutherland, D., Pedersen, J. S. & Otzen, D., 1 Nov 2019, In: Biomolecules. 9, 11, 659.Alterations in Blood Monocyte Functions in Parkinson's Disease
Nissen, S. K., Shrivastava, K., Schulte, C., Otzen, D. E., Goldeck, D., Berg, D., Møller, H. J., Maetzler, W. & Romero-Ramos, M., Nov 2019, In: Movement Disorders. 34, 11, p. 1711-1721 11 p.Molecular dynamics study of ACBP denaturation in alkyl sulfates demonstrates possible pathways of unfolding through fused surfactant clusters
Poghosyan, A. H., Schafer, N., Lyngsø, J., Shahinyan, A. A., Pedersen, J. S. & Otzen, D., Apr 2019, In: Protein Engineering, Design and Selection. 32, 4, p. 175-190 16 p., gzz037.Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures
Juhl, D. W., Risør, M. W., Scavenius, C., Rasmussen, C. B., Otzen, D., Nielsen, N. C. & Enghild, J. J., 7 Mar 2019, In: Scientific Reports. 9, 1, 14 p., 3863.Imperfect repeats in the functional amyloid protein FapC reduce the tendency to fragment during fibrillation
Rasmussen, C. B., Christiansen, G., Vad, B. S., Lynggaard, C., Enghild, J. J., Andreasen, M. & Otzen, D., 1 Mar 2019, In: Protein Science. 28, 3, p. 633-642 10 p.Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation
van Diggelen, F., Hrle, D., Apetri, M., Christiansen, G., Rammes, G., Tepper, A. & Otzen, D. E., Mar 2019, In: PLOS ONE. 14, 3, 22 p., 0213663.Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation
Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G. & Otzen, D. E., Feb 2019, In: ACS Omega. 4, 2, p. 4029-4039 11 p.Physical Determinants of Amyloid Assembly in Biofilm Formation
Andreasen, M., Meisl, G., Taylor, J. D., Michaels, T. C. T., Levin, A., Otzen, D. E., Chapman, M. R., Dobson, C. M., Matthews, S. J. & Knowles, T. P. J., 8 Jan 2019, In: mBio. 10, 1, 12 p., e02279-18.A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants
Mohammad-Beigi, H., Kjær, L., Eskandari, H., Aliakbari, F., Christiansen, G., Ruvo, G., L. Ward, J. & Otzen, D., 2019, In: Frontiers in Plant Science. 10, 148, 15 p., 148.Functional Amyloids
Otzen, D. & Riek, R., 2019, In: Cold Spring Harbor Perspectives in Biology. 11, 12, 30 p.In vitro and in silico assessment of the developability of a designed monoclonal antibody library
Wolf Pérez, A-M., Sormanni, P., Andersen, J. S., Sakhnini, L. I., Rodriguez-Leon, I., Bjelke, J. R., Gajhede, A. J., De Maria, L., Otzen, D. E., Vendruscolo, M. & Lorenzen, N., 2019, In: mAbs. 11, 2, p. 388-400 13 p.Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures
Pedersen, J. N., Jiang, Z., Christiansen, G., Lee, J. C., Pedersen, J. S. & Otzen, D. E., 2019, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 5, p. 519-528 10 p.Mechanistic Understanding of the Interactions between Nano-Objects with Different Surface Properties and α-Synuclein
Mohammad-Beigi, H., Hosseini, A., Adeli, M., Ejtehadi, M. R., Christiansen, G., Sahin, C., Tu, Z., Tavakol, M., Dilmaghani-Marand, A., Nabipour, I., Farzadfar, F., Otzen, D. E., Mahmoudi, M. & Hajipour, M. J., 2019, In: ACS Nano. 13, 3, p. 3243-3256 14 p.Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity
Mohammad-Beigi, H., Aliakbari, F., Sahin, C., Lomax, C., Tawfike, A., P. Schafer, N., Amiri-Nowdijeh, A., Eskandari, H., Møller, I. M., Hosseini-Mazinani, M., Christiansen, G., Ward, J. L., Morshedi, D. & Otzen, D., 2019, In: Journal of Biological Chemistry. 294, 11, p. 4215-4232 18 p.Can a Charged Surfactant Unfold an Uncharged Protein?
Højgaard, C., Sørensen, H. V., Pedersen, J. S., Winther, J. R. & Otzen, D. E., 4 Dec 2018, In: Biophysical Journal. 115, 11, p. 2081-2086The Use of Surfactants to Solubilise a Glucagon Analogue
Madsen, J. K., Giehm, L. & Otzen, D. E., Dec 2018, In: Pharmaceutical Research. 35, 12, 235.Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State
Kurnik, M., Sahin, C., Andersen, C. B., Lorenzen, N., Giehm, L., Mohammad-Beigi, H., Jessen, C. M., Pedersen, J. S., Christiansen, G., Petersen, S. V., Staal, R., Krishnamurthy, G., Pitts, K., Reinhart, P. H., Mulder, F. A. A., Mente, S., Hirst, W. D. & Otzen, D. E., 15 Nov 2018, In: Cell Chemical Biology. 25, 11, p. 1389-1402Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms
Bleem, A., Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, K., Bryers, J. D., Daggett, V., Meyer, R. L. & Otzen, D. E., 12 Oct 2018, In: Journal of Molecular Biology. 430, 20, p. 3751-3763Using Liprotides to Deliver Cholesterol to the Plasma Membrane
Frislev, H. S., Nielsen, J., Nylandsted, J. & Otzen, D., Aug 2018, In: Journal of Membrane Biology. 25, 4, p. 581-592 12 p.Early events in copper-ion catalyzed oxidation of α-synuclein
Tiwari, M. K., Leinisch, F., Sahin, C., Møller, I. M., Otzen, D., Davies, M. J. & Bjerrum, M. J., Jun 2018, In: Free Radical Biology & Medicine. 121, p. 38-50The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease
Aliakbari, F., Mohammad-Beigi, H., Rezaei-Ghaleh, N., Becker, S., Dehghani Esmatabad, F., Eslampanah Seyedi, H. A., Bardania, H., Tayaranian Marvian, A., Collingwood, J. F., Christiansen, G., Zweckstetter, M., Otzen, D. E. & Morshedi, D., 17 May 2018, In: Nanoscale. 10, 19, p. 9174-9185 12 p.High-quality draft genome sequence of Sphaerisporangium cinnabarinum ATCC 31213
Christensen, L. F. B., Otzen, D. & Dueholm, M. S., 1 May 2018, In: Genome Announcements. 6, 21, 2 p., e00456-18.Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation
Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, T., Christiansen, G. & Otzen, D. E., May 2018, In: FEBS Letters. 592, 9, p. 1484-1496Corneal dystrophy mutations drive pathogenesis by targeting TGFBIp stability and solubility in a latent amyloid-forming domain
Stenvang, M., Schafer, N. P., Malmos, K. G., Pérez, A-M. W., Niembro, O., Sormanni, P., Basaiawmoit, R. V., Christiansen, G., Andreasen, M. & Otzen, D. E., 13 Apr 2018, In: Journal of Molecular Biology. 430, 8, p. 1116-1140Stabilizing vitamin D3 using the molten globule state of α-lactalbumin
Pedersen, J. N., Sørensen, H. V. & Otzen, D. E., Mar 2018, In: Journal of Dairy Science. 101, 3, p. 1817–1826Role of charge and hydrophobicity in liprotide formation: a molecular dynamics study with experimental constraints
Nedergaard Pedersen, J., Wilhelmus Johannes Maria Frederix, P., Skov Pedersen, J., Marrink, S. J. & Otzen, D., 2 Feb 2018, In: ChemBioChem. 19, 3, p. 263–271Liprotides assist in folding of outer membrane proteins
Nedergaard Pedersen, J., Skov Pedersen, J. & Otzen, D. E., 1 Feb 2018, In: Protein Science. 27, 2, p. 451-462 12 p.Dynamic content exchange between liprotides
Frislev, H. S., Jakobsen, S. C. L., Frank, S. A. & Otzen, D. E., Feb 2018, In: Biophysical Chemistry. 233, p. 13-18 6 p.Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome
Aliakbari, F., Shabani, A. A., Bardania, H., Mohammad-Beigi, H., Tayaranian Marvian, A., Dehghani Esmatabad, F., Vafaei, A. A., Shojaosadati, S. A., Saboury, A. A., Christiansen, G., Otzen, D. E. & Morshedi, D., 1 Jan 2018, In: Colloids and surfaces. B, Biointerfaces. 161, p. 578-587 10 p.The Sheaths of Methanospirillum Are Made of a New Type of Amyloid Protein
Christensen, L. F. B., Hansen, L. M., Finster, K., Christiansen, G., Nielsen, P. H., Otzen, D. E. & Dueholm, M. S., 2018, In: Frontiers in Microbiology. 9, 11 p., 2729.α-synucleins from animal species show low fibrillation propensities and weak oligomer membrane disruption
Sahin, C., Kjær, L., Christensen, M. S., Nedergaard Pedersen, J., Christiansen, G., Pérez, A-M. W., Moller, I. M., Enghild, J., Pedersen, J. S., Larsen, K. & Otzen, D. E., 2018, In: Biochemistry. 57, 34, p. 5145-5158 14 p.Myoglobin and α-Lactalbumin Form Smaller Complexes with the Biosurfactant Rhamnolipid Than with SDS
Mortensen, H. G., Madsen, J. K., Andersen, K. K., Vosegaard, T., Deen, G. R., Otzen, D. E. & Pedersen, J. S., 19 Dec 2017, In: Biophysical Journal. 113, 12, p. 2621-2633 13 p.Liprotides kill cancer cells by disrupting the plasma membrane
Frislev, H. S., Boye, T. L., Nylandsted, J. & Otzen, D., 9 Nov 2017, In: Scientific Reports. 7, 15129.Correction to: How glycosaminoglycans promote fibrillation of salmon calcitonin
Malmos, K. G., Bjerring, M., Jessen, C. M., Nielsen, E. H. T., Poulsen, E. T., Christiansen, G., Vosegaard, T., Skrydstrup, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. E., 22 Sept 2017, In: Journal of Biological Chemistry. 292, 38, p. 15992The Changing Face of Aging: Highly Sulfated Glycosaminoglycans Induce Amyloid Formation in a Lattice Corneal Dystrophy Model Protein
Malmos, K. G., Stenvang, M., Sahin, C., Christiansen, G. & Otzen, D. E., 1 Sept 2017, In: Journal of Molecular Biology. 429, 18Glycolipid Biosurfactants Activate, Dimerize, and Stabilize Thermomyces lanuginosus Lipase in a pH-Dependent Fashion
Madsen, J. K., Kaspersen, J. D., Andersen, C. B., Nedergaard Pedersen, J., Andersen, K. K., Pedersen, J. S. & Otzen, D. E., 15 Aug 2017, In: Biochemistry. 56, 32, p. 4256-4268 13 p.Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils
Risør, M. W., Juhl, D. W., Bjerring, M., Mathiesen, J., Enghild, J. J., Nielsen, N. C. & Otzen, D. E., 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 580-596 17 p.α-Synuclein Oligomers: A Study in Diversity
van Diggelen, F., Tepper, A., Petri, M. & Otzen, D., Jul 2017, In: Israel Journal of Chemistry. 57, 7-8, p. 699-723Tailoring thermal treatment to form liprotide complexes between oleic acid and different proteins
Sørensen, H. V., Pedersen, J. N., Pedersen, J. S. & Otzen, D. E., Jun 2017, In: BBA Proteins and Proteomics. 1865, 6, p. 682–693Refolding of SDS-Unfolded Proteins by Nonionic Surfactants
Kaspersen, J. D., Søndergaard, A., Madsen, D. J., Otzen, D. E. & Pedersen, J. S., 25 Apr 2017, In: Biophysical Journal. 112, 8, p. 1609-1620 12 p.Biosurfactants and surfactants interacting with membranes and proteins: Same but different?
Otzen, D., Apr 2017, In: BBA Biomembranes. 1859, 4, p. 639–649ThT 101: a primer on the use of thioflavin T to investigate amyloid formation
Malmos, K., Blancas-Mejia, L. M., Weber, B., Buchner, J., Ramirez-Alvarado, M., Naiki, H. & Otzen, D., Apr 2017, In: Amyloid: the Journal of Protein Folding Disorders. 24, 1, p. 1-16 16 p.The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage
Christiansen, S. H., Zhang, X., Juul-Madsen, K., Hvam, M. L., Vad, B. S., Behrens, M. A., Thygesen, I. L., Jalilian, B., Pedersen, J. S., Howard, K., Otzen, D. E. & Vorup-Jensen, T., Mar 2017, In: B B A - Biomembranes. 1859, 3, p. 425-437 13 p.Antibodies against the C-terminus of α-synuclein modulate its fibrillation
Sahin, C., Lorenzen, N., Lemminger, L., Christiansen, G., Møller, I. M., Vesterager, L. B., Pedersen, L. Ø., Fog, K., Kallunki, P. & Otzen, D. E., Jan 2017, In: Biophysical Chemistry. 220, p. 34-41A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis
Rouse, S. L., Hawthorne, W. J., Berry, J-L., Chorev, D. S., Ionescu, S. A., Lambert, S., Stylianou, F., Ewert, W., Mackie, U., Morgan, R. M. L., Otzen, D., Herbst, F-A., Nielsen, P. H., Dueholm, M., Bayley, H., Robinson, C. V., Hare, S. & Matthews, S., 2017, In: Nature Communications. 8, 1, 263.Human lysozyme peptidase resistance is perturbed by the anionic glycolipid biosurfactant rhamnolipid produced by the opportunistic pathogen Pseudomonas aeruginosa
Andersen, K. K., Vad, B. S., Scavenius, C., Enghild, J. J. & Otzen, D. E., 2017, In: Biochemistry. 56, 1, p. 260–270Epigallocatechin Gallate Remodels overexpressed Functional Amyloids in Pseudomonas aeruginosa and Increases Biofilm Susceptibility to Antibiotic Treatment
Stenvang, M., Dueholm, M. S., Vad, B. S., Seviour, T. W., Zeng, G., Geifman-Shochat, S., Søndergaard, M. T., Christiansen, G., Meyer, R. L., Kjelleberg, S., Otzen, D. E. & Nielsen, P. H., 16 Dec 2016, In: Journal of Biological Chemistry. 291, 51, p. 26540-26553Alpha-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles
Pantusa, M., Vad, B., Lillelund, O., Kjær, L., Otzen, D. & Bartucci, R., Sept 2016, In: B B A - Proteins and Proteomics. 1864, p. 1206-1214Using protein-fatty acid complexes to improve vitamin D stability
Pedersen, J. N., Frislev, H. K. S., Pedersen, J. S. & Otzen, D. E., Sept 2016, In: Journal of Dairy Science. 99, 10, p. 7755–7767How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin
Malmos, K. G., Bjerring, M., Jessen, C. M., Nielsen, E. H. T., Poulsen, E. T., Christiansen, G., Vosegaard, T., Skrydstrup, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. E., 5 Aug 2016, In: Journal of Biological Chemistry. 291, 32, p. 16849-16862 31 p.The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity
Jarvela, T. S., Lam, H. A., Helwig, M., Lorenzen, N., Otzen, D. E., McLean, P. J., Maidment, N. T. & Lindberg, I., 25 Jul 2016, In: Proceedings of the National Academy of Sciences. 113, 32A Complex Dance: The Importance of Glycosaminoglycans and Zinc in the Aggregation of Human Prolactin
Christensen, L. F. B., Malmos, K. G., Christiansen, G. & Otzen, D. E., 22 Jun 2016, In: Biochemistry. 55, 26, p. 3674–3684 11 p.Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization
Madsen, J. L. H., Hjørringgaard, C. U., Vad, B. S., Otzen, D. & Skrydstrup, T., 6 Jun 2016, In: Chemistry: A European Journal. 22, 24, p. 8358-8367 10 p.α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology
Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V., 9 Apr 2016, In: Journal of Neuroinflammation. 13, 74.Epigallocatechin gallate remodels fibrils of Lattice Corneal Dystrophy protein, facilitating proteolytic degradation and preventing formation of membrane-permeabilizing species
Stenvang, M., Christiansen, G. & Otzen, D. E., 4 Apr 2016, In: Biochemistry. 55, 16, p. 2344-2357The compact and biologically relevant structure of inter-α-inhibitor is maintained by the chondroitin sulfate chain and divalent cations
Scavenius, C., Nikolajsen, C. L., Stenvang, M., Thøgersen, I., Wyrozemski, L., Wisniewski, H-G., Otzen, D. E., Sanggaard, K. W. & Enghild, J. J., 26 Feb 2016, In: Journal of Biological Chemistry. 291, 9, p. 4658-4670 13 p.Detection of proteolytic signatures for Parkinson's disease
Jordal, P. L., Dyrlund, T. F., Winge, K., Larsen, M. R., Danielsen, E. H., Wells, J. A., Otzen, D. E. & Enghild, J. J., 1 Feb 2016, In: Future Neurology. 11, 1, p. 15-32 18 p.A Monte Carlo Study of the Early Steps of Functional Amyloid Formation
Tian, P., Lindorff-Larsen, K., Boomsma, W., Jensen, M. H. & Otzen, D. E., 8 Jan 2016, In: PLOS ONE. 11, 1Concatemers of Outer Membrane Protein A Take Detours in the Folding Landscape
Andersen, K. K., Vad, B., Omer, S. & Otzen, D. E., 2016, In: Biochemistry. 55, 51, p. 7123–7140 7 p.Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11
Kim, J-Y., Sahu, S., Yau, Y-H., Wang, X., Shochat, S. G., Nielsen, P. H., Dueholm, M. S., Otzen, D. E., Lee, J., Delos Santos, M. M. S., Yam, J. K. H., Kang, N-Y., Park, S-J., Kwon, H., Seviour, T. W., Yang, L., Givskov, M. & Chang, Y-T., 2016, In: Journal of the American Chemical Society. p. 402-407Formation and Characterization of α-Synuclein Oligomers
Paslawski, W., Lorenzen, N. & Otzen, D. E., 2016, In: Methods in molecular biology (Clifton, N.J.). 1345, p. 133-150 18 p.Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation
Mohammad-Beigi, H., Morshedi, D., Shojaosadati, S. A., Pedersen, J. N., Marvian, A. T., Aliakbari, F., Christiansen, G., Pedersen, J. S. & Otzen, D. E., 2016, In: RSC Advances. 6, 88, p. 85312-85323 12 p.Liprotides made of α-lactalbumin and cis fatty acids form core-shell and multi-layer structures with a common membrane-targeting mechanism
Frislev, H. K. S., Jessen, C. M., Oliveira, C. L. P., Pedersen, J. S. & Otzen, D. E., 2016, In: B B A - Proteins and Proteomics. 1864, 7, p. 847-859 13 p.Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T
Kulminskaya, N. V., Yoshimura, Y., Runager, K., Sørensen, C. S., Bjerring, M., Andreasen, M., Otzen, D. E., Enghild, J. J., Nielsen, N. C. & Mulder, F. A. A., 2016, In: Biomolecular N M R Assignments. 10, 1, p. 25-29 5 p.Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin
Hjorth, C. F., Norrman, M., Wahlund, P-O., Benie, A. J., Petersen, B. O., Jessen, C. M., Pedersen, T. Å., Vestergaard, K., Steensgaard, D. B., Pedersen, J. S., Naver, H., Hubálek, F., Poulsen, C. & Otzen, D., 2016, In: Journal of Pharmaceutical Sciences. 105, 4, p. 1376-1386 11 p.The transcriptional regulator GalR self-assembles to form highly regular tubular structures
Agerschou, E. D., Christiansen, G., Schafer, N. P., Madsen, D. J., Brodersen, D. E., Semsey, S. & Otzen, D. E., 2016, In: Scientific Reports. 6, 27672.Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease
Schafer, N., Truong, H. H., Otzen, D., Lindorff-Larsen, K. & Wolynes, P. G., 2016, In: Proceedings of the National Academy of Sciences. 113, 8, p. 2098-2103Weak and Saturable Protein-Surfactant Interactions in the Denaturation of Apo-α-Lactalbumin by Acidic and Lactonic Sophorolipid
Andersen, K. K., Vad, B. S., Roelants, S., van Bogaert, I. N. A. & Otzen, D. E., 2016, In: Frontiers in Microbiology. 7, 1711.Promoting protein self-association in non-glycosylated Thermomyces lanuginosus lipase based on crystal lattice contacts
Madsen, J., Sørensen, T. R., Kaspersen, J. D., Silow, M. B., Vind, J., Pedersen, J. S., Svendsen, A. & Otzen, D. E., Dec 2015, In: BBA Proteins and Proteomics. 154, 12, p. 1914-1921 8 p.Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment
Christoffersen, H. F., Andreasen, M., Zhang, S., Nielsen, E. H., Christiansen, G., Dong, M., Skrydstrup, T. & Otzen, D. E., Dec 2015, In: B B A - Proteins and Proteomics. 1854, 12, p. 1890-1897 8 p.Strong interactions with polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA NPs) alter α-synuclein conformation and aggregation kinetics
Mohammad-Beigi, H., Shojaosadati, S. A., Marvian, A. T., Pedersen, J. N., Klausen, L. H., Christiansen, G., Pedersen, J. S., Dong, M., Morshedi, D. & Otzen, D. E., 9 Nov 2015, In: Nanoscale. 7, p. 19627-19640 14 p.Sucrose prevents protein fibrillation through compaction of the tertiary structure but hardly affects the secondary structure
Estrela, N., Franquelim, H. G., Lopes, C., Tavares, E., Macedo, J. A., Christiansen, G., Otzen, D. E. & Melo, E. P., Nov 2015, In: Proteins: Structure, Function, and Bioinformatics. 83, 11, p. 2039-2051 14 p.The length distribution of frangible biofilaments
Michaels, T. C. T., Yde, P., Willis, J. C. W., Jensen, M. H., Otzen, D., Dobson, C. M., Buell, A. K. & Knowles, T. P. J., 28 Oct 2015, In: Journal of Chemical Physics. 143, 16, p. 1-15 15 p., 164901.Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness
Zeng, G., Vad, B. S., Dueholm, M. S., Christiansen, G., Nilsson, M., Tolker-Nielsen, T., Nielsen, P. H., Meyer, R. L. & Otzen, D. E., 7 Oct 2015, In: Frontiers in Microbiology. 6, p. 1099Interactions between misfolded protein oligomers and membranes: A central topic in neurodegenerative diseases?
Andreasen, M., Lorenzen, N. & Otzen, D., Sept 2015, In: B B A - Molecular and Cell Biology of Lipids. 1848, 9, p. 1897-1907The natural, peptaibolic peptide SPF-5506-A4 adopts a β-bend spiral structure, shows low hemolytic activity and targets membranes through formation of large pores
Frahm, H., Hansen, S. K., Vad, B. S., Nielsen, E. H., Nielsen, J. T., Vosegaard, T., Skrydstrup, T. & Otzen, D. E., Aug 2015, In: B B A - Proteins and Proteomics. 1854, 8, p. 882-889 8 p.The Use of Liprotides To Stabilize and Transport Hydrophobic Molecules
Pedersen, J. N., Pedersen, J. S. & Otzen, D. E., 28 Jul 2015, In: Biochemistry. 54, 31, p. 4815-4823 9 p.The Tubular Sheaths Encasing Methanosaeta thermophila Filaments are Functional Amyloids
Dueholm, M. S., Larsen, P., Finster, K., Stenvang, M. R., Christiansen, G., Vad, B. S., Bøggild, A., Otzen, D. E. & Halkjær Nielsen, P., 24 Jun 2015, In: Journal of Biological Chemistry. 290, p. 20590-26600 11 p.Proteins in a brave new surfactant world
Otzen, D. E., 1 Jun 2015, In: Current Opinion in Colloid & Interface Science. 20, 3, p. 161-169 9 p.Phospholipid Ether Linkages Significantly Modulate the Membrane Affinity of the Antimicrobial Peptide Novicidin
Vad, B. S., Balakrishnan, V. S., Nielsen, S. B. & Otzen, D., Jun 2015, In: Journal of Membrane Biology. p. 487-496 10 p.Purification and Identification of High Molecular Weight Products Formed During Storage of Neutral Formulation of Human Insulin
Hjorth, C. F., Hubálek, F., Andersson, J., Poulsen, C., Otzen, D. & Naver, H., Jun 2015, In: Pharmaceutical Research. 32, 6, p. 2072-2085 14 p.The anionic biosurfactant rhamnolipid does not denature industrial enzymes
Madsen, J., Pihl, R., Møller, A. H., Tranberg Madsen, A., Otzen, D. & Andersen, K. K., 17 Apr 2015, In: Frontiers in Microbiology. 6, 13 p., 292.A monomer-trimer model supports intermittent glucagon fibril growth
Košmrlj, A., Cordsen, P., Kyrsting, A., Otzen, D., Oddershede, L. B. & Jensen, M. H., 11 Mar 2015, In: Scientific Reports. 5, p. 1-6 6 p., 9005.Protein aggregation: Close encounters of the greasy kind
Otzen, D., 17 Feb 2015, In: Nature Chemical Biology. 11, 3, p. 176-177 2 p.Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
Paslawski, W., Lillelund, O. K., Kristensen, J. V., Schafer, N. P., Baker, R. P., Urban, S. & Otzen, D. E., 10 Feb 2015, In: Proceedings of the National Academy of Sciences. 112, 6, p. 7978-7983 6 p.Functional Amyloids Keep Quorum Sensing Molecules in Check
Seviour, T., Hansen, S. H., Yang, L., Yau, Y. H., Wang, V. B., Stenvang, M. R., Christiansen, G., Marsili, E., Givskov, M., Chen, Y., Otzen, D., Nielsen, P. H., Shochat, S. G., Kjelleberg, S. & Dueholm, M. S., 13 Jan 2015, In: Journal of Biological Chemistry. 290, p. 6457-6469 13 p.Structure of a Functional Amyloid Protein Subunit Computed Using Sequence Variation
Tian, P., Boomsma, W., Wang, Y., Otzen, D., Jensen, M. H. & Lindorff-Larsen, K., 2015, In: Journal of the American Chemical Society. 137, 1, p. 22-25 4 p.Folding energetics and oligomerization of polytopic α-helical transmembrane proteins
Neumann, J., Klein, N., Otzen, D. & Schneider, D., 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 281–296 16 p.Membrane protein folding and stability
Otzen, D., 15 Dec 2014, In: Archives of Biochemistry and Biophysics. 564, p. 262-264 3 p.Denaturation of α-lactalbumin and myoglobin by the anionic biosurfactant rhamnolipid
Andersen, K. K. & Otzen, D., Dec 2014, In: B B A - Bioenergetics. 1844, 12, p. 2338-2345 8 p.Generic Structures of Cytotoxic Liprotides: Nano-Sized Complexes with Oleic Acid Cores and Shells of Disordered Proteins
Kaspersen, J. D., Pedersen, J. N., Hansted, J. G., Nielsen, S. B., Sakthivel, S., Wilhelm, K., Nemashkalova, E. L., Permyakov, S. E., Permyakov, E. A., Pinto Oliveira, C. L., Morozova-Roche, L. A., Otzen, D. & Pedersen, J. S., Dec 2014, In: ChemBioChem. 10, 18, p. 2693-2702 10 p.The Antimicrobial Mechanism of Action of Epsilon-Poly-L-Lysine
Hyldgaard, M., Mygind, T., Vad, B. S., Stenvang, M., Otzen, D. & Meyer, R. L., Dec 2014, In: Applied and Environmental Microbiology. 80, 24, p. 7758-7770 12 p.The Importance of Being Capped: Terminal Capping of an Amyloidogenic Peptide Affects Fibrillation Propensity and Fibril Morphology
Andreasen, M., Skeby, K. K., Zhang, S., Nielsen, E. H., Klausen, L. H., Frahm, H., Christiansen, G., Skrydstrup, T., Dong, M., Schiøtt, B. & Otzen, D., 21 Oct 2014, In: Biochemistry. 53, 44, p. 6968-6980 13 p.High stability and cooperative unfolding of cytotoxic α-synuclein oligomers
Paslawski, W., Andreasen, M., Nielsen, S. B., Lorenzen, N., Thomsen, K., Kaspersen, J. D., Pedersen, J. S. & Otzen, D., 12 Sept 2014, In: Biochemistry. 53, 39, p. 6252-6263 12 p.Low-Resolution Structures of OmpA⋅DDM Protein-Detergent Complexes
Kaspersen, J., Moestrup Jessen, C., Stougaard Vad, B., Skipper Sørensen, E., Kleiner Andersen, K., Glasius, M., Pinto Oliveira, C. L., Otzen, D. & Pedersen, J. S., 19 Aug 2014, In: ChemBioChem. 15, 14, p. 2113-2124 12 p.Oligomers of α-synuclein: picking the culprit in the line-up
Lorenzen, N. & Otzen, D., 18 Aug 2014, In: Essays in Biochemistry. 56, 1, p. 137-148 12 p.How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro
Lorenzen, N., Nielsen, S. B., Yoshimura, Y., Vad, B. S., Andersen, C. B., Betzer, C., Kaspersen, J. D., Christiansen, G., Pedersen, J. S., Jensen, P. H., Mulder, F. A. A. & Otzen, D. E., 1 Aug 2014, In: Journal of Biological Chemistry. 289, 31, p. 21299-21310 12 p.Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry
Paslawski, W., Mysling, S., Thomsen, K., Jørgensen, T. J. D. & Otzen, D., 14 Jul 2014, In: Angewandte Chemie International Edition. 53, 29, p. 7560-7563 4 p.Bacterial RTX Toxins Allow Acute ATP Release from Human Erythrocytes Directly through the Toxin Pore
Skals, M., Bjaelde, R. G., Reinholdt, J., Poulsen, K., Vad, B. S., Otzen, D., Leipziger, J. & Praetorius, H. A., 4 Jul 2014, In: Journal of Biological Chemistry. 289, p. 19098-19109 11 p.Condenser: A statistical aggregation tool for multi-sample quantitative proteomic data from Matrix Science Mascot Distiller™
Knudsen, A. D., Bennike, T., Kjeldal, H., Birkelund, S., Otzen, D. & Stensballe, A., 30 May 2014, In: Journal of Proteomics. 103, p. 261-266 6 p.Folding of outer membrane protein A in the anionic biosurfactant rhamnolipid
Andersen, K. K. & Otzen, D., 21 May 2014, In: FEBS Letters. 588, 10, p. 1955-1960 6 p.Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene
Poulsen, E. T., Runager, K., Risør, M. W., Dyrlund, T. F., Scavenius, C., Karring, H., Praetorius, J., Vorum, H., Otzen, D. E., Klintworth, G. K. & Enghild, J. J., Apr 2014, In: Proteomics - Clinical Applications. 8, 3-4, p. 168-177 10 p.The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
Lorenzen, N., Nielsen, S. B., Buell, A. K., Kaspersen, J. D., Arosio, P., Vad, B. S., Paslawski, W., Christiansen, G., Valnickova Hansen, Z., Andreasen, M., Enghild, J. J., Pedersen, J. S., Dobson, C. M., Knowles, T. P. J. & Otzen, D., 16 Feb 2014, In: Journal of the American Chemical Society. 136, 10, p. 3859-3868 10 p.Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation
Kronqvist, N., Otikovs, M., Chmyrov, V., Chen, G., Andersson, M., Nordling, K., Landreh, M., Sarr, M., Jörnvall, H., Wennmalm, S., Widengren, J., Meng, Q., Rising, A., Otzen, D., Knight, S. D., Jaudzems, K. & Johansson, J., 10 Feb 2014, In: Nature Communications. 5, 11 p., 3254.The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes
Lorenzen, N., Lemminger, L., Pedersen, J. N., Nielsen, S. B. & Otzen, D., 31 Jan 2014, In: FEBS Letters. 588, 3, p. 497-502 6 p.Electrochemical Analysis of the Fibrillation of Parkinson's Disease α-synuclein
Lopes, P., Dyrnesli, H., Lorenzen, N., Otzen, D. & Ferapontova, E., 2014, In: Analyst. 139, 4, p. 749-756 8 p.Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization
Underhaug, J., Koldsø, H., Runager, K., Nielsen, J. T., Sørensen, C. S., Kristensen, T., Otzen, D., Karring, H., Malmendal, A., Schiøtt, B., Enghild, J. J. & Nielsen, N. C., 12 Oct 2013, In: BBA General Subjects. 1834, 12, p. 2812–2822 11 p.Evolutionary Insight into the Functional Amyloids of the Pseudomonads
Dueholm, M. S., Otzen, D. & Nielsen, P. H., 7 Oct 2013, In: PLOS ONE. 8, 10, p. 1-9 9 p., e76630.Formation of dynamic soluble surfactant-induced amyloid β peptide aggregation intermediates
Abelein, A., Kaspersen, J. D., Nielsen, S. B., Jensen, G. V., Christiansen, G., Pedersen, J. S., Danielsson, J. A., Otzen, D. & Gräslund, A., 9 Aug 2013, In: Journal of Biological Chemistry. 288, p. 23518-23528 11 p.Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation
Dueholm, M. S., Søndergaard, M., Nilsson, M., Christiansen, G., Stensballe, A., Overgaard, M. T., Givskov, M. C., Tolker-Nielsen, T., Otzen, D. & Nielsen, P. H., Jun 2013, In: MicrobiologyOpen. 2, 3, p. 365-382 13 p.Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Cohen, S. I. A., Linse, S., Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D., Vendruscolo, M., Dobson, C. M. & Knowles, T. P. J., 23 May 2013, In: PNAS (Proceedings of the National Academy of Sciences of the United States of America). 110, 24, p. 9758-9763 6 p.Quality control system response to stochastic growth of amyloid fibrils
Pigolotti, S., Lizana, L., Otzen, D. & Sneppen, K., 2 May 2013, In: F E B S Letters. 587, 9, p. 1405-1410 6 p.Novicidin's membrane permeabilizing activity is driven by membrane partitioning but not by helicity: A biophysical study of the impact of lipid charge and cholesterol
Balakrishnan, V. S., Vad, B. S. & Otzen, D., 2 Apr 2013, In: BBA General Subjects. 1834, 6, p. 996-1002 7 p.Protein:fatty acid complexes: Biochemistry, biophysics and function
Brinkmann, C. R., Thiel, S. & Otzen, D., Apr 2013, In: F E B S Journal. 280, 8, p. 1733–1749Off-pathway aggregation can inhibit fibrillation at high protein concentrations
Deva, T., Lorenzen, N., Vad, B. S., Petersen, S. V., Thørgersen, I., Enghild, J. J., Kristensen, T. & Otzen, D., Mar 2013, In: BBA General Subjects. 1834, 3, p. 677-687 11 p.Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: a candidate for enzyme replacement therapy
Wang, H., Hagedorn, J., Svendsen, A., Borch, K. & Otzen, D., Feb 2013, In: Biophysical Chemistry. 172, p. 43-52 10 p.The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins
Helwig, M., Hoshino, A., Berridge, C., Lee, S-N., Lorenzen, N., Otzen, D., Eriksen, J. & Lindberg, I., 11 Jan 2013, In: Journal of Biological Chemistry. 288, 2, p. 1114 1124 p.pH regulation of the kinetic stability of the lipase from Thermomyces lanuginosus
Wang, H., Andersen, K. K., Sehgal, P., Hagedorn, J., Westh, P., Borch, K. & Otzen, D. E., 8 Jan 2013, In: Biochemistry. 52, 1, p. 264-276 13 p.OmpA can form folded and unfolded oligomers
Wang, H., Andersen, K. K., Vad, B. S. & Otzen, D. E., 1 Jan 2013, In: B B A - Proteins and Proteomics. 1834, 1, p. 127-136 10 p.Coexistence of ribbon and helical fibrils originating from hIAPP20-29 revealed by quantitative nanomechanical atomic force microscopy
Zhang, S., Andreasen, M., Nielsen, J. T., Liu, L., Nielsen, E. H., Song, J., Ji, G., Sun, F., Skrydstrup, T., Besenbacher, F., Nielsen, N. C., Otzen, D. E. & Dong, M., 2013, In: PNAS (Proceedings of the National Academy of Sciences of the United States of America). 110, 8, p. 2798-2803 6 p.Folding of outer membrane proteins
Otzen, D. & Andersen, K. K., 2013, In: Archives of Biochemistry and Biophysics. 531, 1-2, p. 34-43 10 p.Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures
Nielsen, S. B., Macchi, F., Raccosta, S., Langkilde, A. E., Giehm, L., Kyrsting, A., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L., Vestergaard, B. & Otzen, D., 2013, In: P L o S One. 8, 7, e67713.Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure
Dueholm, M. S., Albertsen, M., Otzen, D. & Nielsen, P. H., 12 Dec 2012, In: P L o S One. 7, 12, p. e51274 18 p.Eurocin, a new fungal defensin: structure, lipid binding and its mode of action
Oeemig, J. S., Lynggaard, C., Knudsen, D., Hansen, F. T., Noergaard, K. D., Schneider, T., Vad, B. S., Sandvang, D., Nielsen, L., Neve, S., Kristensen, H-H., Sahl, H-G., Otzen, D. & Wimmer, R., 7 Dec 2012, In: Journal of Biological Chemistry. 7, p. 42361-42372 11 p.Polymorphic Fibrillation of the Destabilized Fourth Fasciclin-1 Domain Mutant A546T of the Transforming Growth Factor-β-induced Protein (TGFBIp) Occurs through Multiple Pathways with Different Oligomeric Intermediates
Andreasen, M., Nielsen, S. B., Runager, K., Christiansen, G., Nielsen, N. C., Enghild, J. J. & Otzen, D., 5 Oct 2012, In: Journal of Biological Chemistry. 287, 41, p. 34730-34742 12 p.A Kinetic Analysis of the Folding and Unfolding of OmpA in Urea and Guaninidinium Chloride: Single and Parallel Pathways
Andersen, K. K., Wang, H. & Otzen, D., 12 Sept 2012, In: Biochemistry. 51, 42, p. 8371-8383 12 p.Cyclodextrin-Scaffolded Alamethicin with Remarkably Efficient Membrane Permeabilizing Properties and Membrane Current Conductance
Hjørringgaard, C. U., Vad, B. S., Matchkov, V., Nielsen, S. B., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T., 5 Jul 2012, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 116, 26, p. 7652-7659 8 p.Proteolytic activation of proteose peptone component 3 by release of a C-terminal peptide with antibacterial properties
Pedersen, L. R. L., Hansted, J. G., Nielsen, S. B., Petersen, T. E., Sørensen, U. S., Otzen, D. & Sørensen, E. S., 1 Jun 2012, In: Journal of Dairy Science. 95, 6, p. 2819-2829 11 p.Role of elongation and secondary pathways in S6 amyloid fibril growth
Lorenzen, N., Cohen, S. I. A., Nielsen, S. B., Herling, T. W., Christiansen, G., Dobson, C. M., T. P. Knowles, T. & Otzen, D., 2 May 2012, In: Biophysical Journal. 102, 9, p. 2167-2175 9 p.Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition
Otzen, D., Blans, K., Wang, H., Gilbert, G. E. & Rasmussen, J. T., Apr 2012, In: BBA General Subjects. 1818, 4, p. 1019-1027 9 p.The effect of osmolytes on protein fibrillation
Macchi, F., Eisenkolb, M., Kiefer, H. & Otzen, D., 21 Mar 2012, In: International Journal of Molecular Sciences (Online). 13, 3, p. 3801-3819 19 p.Mapping out the multistage fibrillation of glucagon
Ghodke, S., Nielsen, S. B., Christiansen, G., Hjuler, H. A., Flink, J., Otzen, D. & Nielsen, S. B., Mar 2012, In: F E B S Journal. 279, 5, p. 752-765 13 p.A Ser residue influences the structure and stability of a Pro-kinked transmembrane helix dimer
Weber, M., Tome, L., Otzen, D. & Schneider, D., 2012, In: BBA General Subjects. 1818, 9, p. 2103-7 5 p.Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant
Calcutta, A., Jessen, C. M., Behrens, M. A., Oliveira, C. L. P., Renart, M. L., González-Ros, J. M., Otzen, D., Pedersen, J. S., Malmendal, A. & Nielsen, N. C., 2012, In: B B A - Biomembranes. 1818, 9, p. 2290-301 12 p.Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone
Andreasen, M., Nielsen, S. B., Mittag, T., Bjerring, M., Nielsen, J. T., Zhang, S., Nielsen, E. H., Jeppesen, M., Christiansen, G., Besenbacher, F., Dong, M., Nielsen, N. C., Skrydstrup, T. & Otzen, D. E., 2012, In: B B A - Proteins and Proteomics. 1824, 2, p. 274-85 12 p.Multiple Roles of Heparin in the Aggregation of p25α
Nielsen, S. B., Yde, P., Giehm, L., Sundbye, S., Christiansen, G., Matthiesen, J., Jensen, M. H., Jensen, P. H. & Otzen, D. E., 2012, In: Journal of Molecular Biology.N for AsN - O for StrOcture? A strand-loop-strand motif for prokaryotic O-glycosylation
Otzen, D., 2012, In: Molecular Oral Microbiology.PP3 forms stable tetrameric structures through hydrophobic interactions via the C-terminal amphipathic helix and undergoes reversible thermal dissociation and denaturation
Pedersen, L. R. L., Nielsen, S. B., Hansted, J. G., Petersen, T. E., Otzen, D. E. & Sørensen, E. S., 2012, In: F E B S Journal. 279, 2, p. 336-47 12 p.Scanning tunneling microscopy reveals single-molecule insights into the self-assembly of amyloid fibrils
Kalashnyk, N., Nielsen, J. T., Nielsen, E. H., Skrydstrup, T., Otzen, D., Lægsgaard, E., Wang, C., Besenbacher, F., Nielsen, N. C. & Linderoth, T. R., 2012, In: A C S Nano. 6, 8, p. 6882-6889 8 p.Aβ1-16 Can Aggregate and induce the Production of Reactive Oxygen Species, Nitric Oxide, and Inflammatory Cytokines
Du, X., Wang, L., Wang, Y., Andreasen, M., Zhan, D., Feng, Y., Li, M., Zhao, M., Otzen, D., Xue, D., Yang, Y. & Liu, R., Nov 2011, In: Journal of Alzheimer's Disease. 27, 2, p. 401-413 12 p.Assembling good amyloid some structures at last
Otzen, D. E., 7 Sept 2011, In: Structure. 19, 9, p. 1207-1209 3 p.Hydrogen exchange mass spectrometry as an analytical tool for the analysis of amyloid fibrillogenesis
Scavenius, C., Ghodke, S., Otzen, D. E. & Enghild, J. J., 30 Apr 2011, In: International Journal of Mass Spectrometry. 302, 1-3, p. 167-173 7 p.Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation
Giehm, L., Svergun, D. I., Otzen, D. E. & Vestergaard, B., 22 Feb 2011, In: Proceedings of the National Academy of Sciences. 108, 8, p. 3246-3251 6 p.Human Phenotypically Distinct TGFBI Corneal Dystrophies Are Linked to the Stability of the Fourth FAS1 Domain of TGFBIp
Runager, K., Basaiawmoit, R. V., Deva, T., Andreasen, M., Valnickova, Z., Sørensen, C. S., Karring, H., Thøgersen, I. B., Christiansen, G., Underhaug, J., Kristensen, T., Nielsen, N. C., Klintworth, G. K., Otzen, D. E. & Enghild, J. J., 18 Feb 2011, In: Journal of Biological Chemistry. 286, 7, p. 4951-8 8 p.Mapping the folding pathway of the transmembrane protein DsbB by protein engineering
Otzen, D. E., 1 Jan 2011, In: Protein Engineering Design and Selection (Print). 24, 1-2, p. 139-149 11 p.The role of membrane properties in Mistic folding and dimerisation
Debnath, D. K., Basaiawmoit, R. V., Nielsen, K. L. & Otzen, D. E., 1 Jan 2011, In: Protein Engineering Design and Selection (Print). 24, 1-2, p. 89-97 9 p.Assays for alpha-synuclein aggregation
Giehm, L., Lorenzen, N. & Otzen, D., 2011, In: Methods. 53, 3, p. 295-305 11 p.Effect of protein-surfactant interactions on aggregation of β-lactoglobulin
Hansted, J. G., Wejse, P. L., Bertelsen, H. & Otzen, D. E., 2011, In: BBA General Subjects. 1814, 5, p. 713-723 11 p.Fibrillation of the major curli subunit CsgA under a wide range of conditions implies a robust design of aggregation
Dueholm, M. S., Nielsen, S. B., Hein, K. L., Nissen, P., Chapman, M., Christiansen, G., Nielsen, P. H. & Otzen, D. E., 2011, In: Biochemistry. 50, 39, p. 8281-90 10 p.Long-term-stable ether-lipid vs conventional ester-lipid bicelles in oriented solid-state NMR: altered structural information in studies of antimicrobial peptides
Bertelsen, K., Vad, B., Nielsen, E. H. T., Hansen, S. K., Skrydstrup, T., Otzen, D., Vosegaard, T. & Nielsen, N. C., 2011, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 115, 8, p. 1767-1774 8 p.Mechanical stress affects glucagon fibrillation kinetics and fibril structure
Macchi, F., Hoffmann, S. V., Carlsen, M., Vad, B. S., Imparato, A., Rischel, C. & Otzen, D., 2011, In: Langmuir. 27, 20, p. 12539–12549Protein-surfactant interactions a tale of many states
Otzen, D., 2011, In: BBA General Subjects. 1814, 5, p. 562-91 30 p.SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation
Basaiawmoit, R. V., Oliveira, C. L. P., Runager, K., Sørensen, C. S., Behrens, M. A., Jonsson, B-H., Kristensen, T., Klintworth, G. K., Enghild, J. J., Pedersen, J. S. & Otzen, D. E., 2011, In: Journal of Molecular Biology. 408, 3, p. 503-513 11 p.SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH
Weber, M., Schneider, D., Prodöhl, A., Dreher, C., Becker, C., Underhaug, J., Svane, A. S. P., Malmendal, A., Nielsen, N. C. & Otzen, D., 2011, In: Journal of Molecular Biology. 407, 4, p. 594-606 13 p.Soft Interactions at Nanoparticles Alter Protein Function and Conformation in a Size Dependent Manner
Wang, J., Jensen, U. B., Jensen, G. V., Shipovskov, S., Balakrishnan, V. S., Otzen, D., Pedersen, J. S., Besenbacher, F. & Sutherland, D. S., 2011, In: Nano Letters. 11, 11, p. 4985-4991 6 p.Assays for α-synuclein aggregation
Giehm, L., Lorenzen, N. & Otzen, D. E., 14 Dec 2010, In: Methods.Human phenotypically distinct TGFI corneal dystrophies are linked to the stability of the fourth Fas1 domain of TGFBIp
Otzen, D. & Enghild, J. J., 6 Dec 2010, In: Journal of Biological Chemistry.Strategies to increase the reproducibility of α-synuclein fibrillation in plate reader assays
Giehm, L. & Otzen, D., 15 Nov 2010, In: Analytical Biochemistry. 406, 2, p. 270-281 12 p.Cell-free synthesis and folding of transmembrane OmpA reveals higher order structures and premature truncations
Debnath, D. K. & Otzen, D. E., 1 Nov 2010, In: Advances in Biophysical Chemistry. 152, 1-3, p. 80-8 9 p.Amyloid structure--one but not the same: the many levels of fibrillar polymorphism
Pedersen, J. S., Andersen, C. B. & Otzen, D., Nov 2010, In: The F E B S Journal (Online). 277, 22, p. 4591-4601 11 p.An Aß concatemer with altered aggregation propensities
Giehm, L., Dal Degan, F., Fraser, P., Klysner, S. & Otzen, D. E., 1 Oct 2010, In: BBA General Subjects. 1804, 10, p. 2025-35 11 p.Functional amyloid: turning swords into plowshares
Otzen, D., 1 Oct 2010, In: Prion. 4, 4, p. 256-64 9 p.Cyclodextrin scaffolded alamethicin with highly efficient channel-forming properties
Hjørringgaard, C. U., Vad, B., Nielsen, S. B., Matchkov, V., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T., Sept 2010, In: Journal of Peptide Science. 16, p. 148 1 p.Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?
Otzen, D. E., 1 Aug 2010, In: Current protein & peptide science. 11, 5, p. 355-71 17 p.beta-Sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles
Nielsen, S. B., Franzmann, M., Basaiawmoit, R. V., Wimmer, R., Mikkelsen, J. D. & Otzen, D. E., 1 Aug 2010, In: Biopolymers. 93, 8, p. 678-89 12 p.Stop-and-go kinetics in amyloid fibrillation
Ferkinghoff-Borg, J., Fonslet, J., Andersen, C. B., Krishna, S., Pigolotti, S., Yagi, H., Goto, Y., Otzen, D. & Jensen, M. H., 1 Jul 2010, In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics. 82, 1 Pt 1, p. 010901The diversity of FtsY-lipid interactions
Reinau, M. E., Thøgersen, I. B., Enghild, J. J., Nielsen, K. L. & Otzen, D. E., 1 Jul 2010, In: Biopolymers. 93, 7, p. 595-606 12 p.Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein
Triano, I., Barrera, F. N., Renart, M. L., Molina, M. L., Fernández-Ballester, G., Poveda, J. A., Fernández, A. M., Encinar, J. A., Ferrer-Montiel, A. V., Otzen, D. & González-Ros, J. M., 29 Jun 2010, In: Biochemistry. 49, 25, p. 5397-5404 8 p.A thermodynamic analysis of fibrillar polymorphism
Jeppesen, M. D., Hein, K., Nissen, P., Westh, P. & Otzen, D. E., 1 Jun 2010, In: Advances in Biophysical Chemistry. 149, 1-2, p. 40-6 7 p.Strategies to increase the reproducibility of protein fibrillization in plate reader assays
Giehm, L. & Otzen, D. E., 15 May 2010, In: Analytical Biochemistry. 400, 2, p. 270-81 12 p.In vitro association of fragments of a beta-sheet membrane protein
Debnath, D., Nielsen, K. L. & Otzen, D. E., 1 May 2010, In: Advances in Biophysical Chemistry. 148, 1-3, p. 112-20 9 p.Fast mapping of global protein folding states by multivariate NMR: a GPS for proteins
Malmendal, A., Underhaug, J., Otzen, D. E. & Nielsen, N. C., 21 Apr 2010, In: P L o S One. 5, 4, p. e10262 6 p.The role of protonation in protein fibrillation
Jeppesen, M. D., Westh, P. & Otzen, D. E., 19 Feb 2010, In: FEBS Letters. 584, 4, p. 780-4 5 p.Pardaxin permeabilizes vesicles more efficiently by pore formation than by disruption
Vad, B. S., Bertelsen, K., Johansen, C. H., Pedersen, J. M., Skrydstrup, T., Nielsen, N. C. & Otzen, D. E., 17 Feb 2010, In: Biophysical Journal. 98, 4, p. 576-85 10 p.Impact of the antimicrobial peptide Novicidin on membrane structure and integrity
Nielsen, S. B. & Otzen, D. E., 28 Jan 2010, In: Journal of Colloid and Interface Science. 345, 2, p. 248-256 9 p.Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin
Hein, K. L., Kragh-Hansen, U., Morth, J. P., Jeppesen, M., Otzen, D., Møller, J. V. & Nissen, P., 2010, In: Journal of Structural Biology. 171, p. 353-360Divorcing folding from function: how acylation affects the membrane-perturbing properties of an antimicrobial peptide
Vad, B. S., Thomsen, L. A. H., Bertelsen, K., Franzmann, M., Pedersen, J. M., Nielsen, S. B., Vosegaard, T., Valnickova, Z., Skrydstrup, T., Enghild, J. J., Wimmer, R., Nielsen, N. C. & Otzen, D., 2010, In: B B A - Proteins and Proteomics. 1804, 4, p. 806-20 15 p.Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates
Valnickova, Z., Sanglas, L., Arolas, J. L., Petersen, S. V., Schar, C., Otzen, D., Aviles, F. X., Gomis-Ruth, F. X. & Enghild, J. J., 2010, In: Journal of Biological Chemistry.Functional amyloid in Pseudomonas
Dueholm, M. S., Petersen, S. V., Sønderkær, M., Larsen, P., Christiansen, G., Hein, K. L., Enghild, J. J., Nielsen, J. L., Nielsen, K. L., Nielsen, P. H. & Otzen, D. E., 2010, In: Molecular Microbiology.Functional bacterial amyloids in biofilms
Otzen, D., 2010, In: Annual Biofilm Highlights.Glucagon fibril polymorphism reflects differences in protofilament backbone structure
Andersen, C. B., Hicks, M. R., Vetri, V., Vandahl, B., Rahbek-Nielsen, H., Thøgersen, H., Thøgersen, I., Enghild, J. J., Serpell, L. C., Rischel, C. & Otzen, D. E., 2010, In: Journal of Molecular Biology. 397, 4, p. 932-46 14 p.Institutional nonconformism: the many levels of glucagon polymorphism
Otzen, D., 2010, In: F E B S Journal.Membrane Interactions of Novicidin, a Novel Antimicrobial Peptide: Phosphatidylglycerol Promotes Bilayer Insertion
Dorosz, J., Gofman, Y., Kolusheva, S., Otzen, D., Ben-Tal, N., Nielsen, N. C. & Jelinek, R., 2010, In: The Journal of Physical Chemistry B. 114, 34, p. 11053-60 8 p.Occupancy of non-annular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein
Otzen, D., 2010, In: Biochemistry.SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway
Giehm, L., Oliveira, C. L. P. D., Christiansen, G., Pedersen, J. S. & Otzen, D., 2010, In: Journal of Molecular Biology. 401, p. 115-133Surfactants and alcohols as inducers of protein amyloid: aggregation chaperones or membrane simulators?
Otzen, D., 2010, In: Lipids and membranes in amyloid diseases.The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism
Nielsen, S. B., Wilhelm, K., Vad, B., Schleucher, J., Morozova-Roche, L. A. & Otzen, D., 2010, In: Journal of Molecular Biology. 398, 2, p. 351-61 11 p.Synthesis of a Ketomethylene Isostere of the Fibrillating Peptide SNNFGAILSS
Mittag, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T., 9 Sept 2009, In: Journal of Organic Chemistry. 74, p. 7955-7957A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis
Huynh, T. H. V., Mantel, M., Mikkelsen, K., Lindhardt, A. T., Nielsen, N. C., Otzen, D. & Skrydstrup, T., 22 Jan 2009, In: Organic Letters. 11, p. 999-1002Branching in amyloid fibril growth
Beyschau Andersen, C., Yagi, H., Manno, M., Martorana, V., Ban, T., Christiansen, G., Otzen, D., Goto, Y. & Rischel, C., 2009, In: Biophysical Journal. 96, 4, p. 1529-36 7 p.How chain length and charge affect surfactant denaturation of ACBP
Andersen, K. & Otzen, D., 2009, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 113, p. 13942-13952Influence of tunable external stimuli on the self-assembly of guanosine supramolecular nanostructures studied by atomic force microscope
Li, Y., Dong, M., Otzen, D., Yao, Y., Liu, B., Besenbacher, F. & Mamdouh, W., 2009, In: Langmuir. 25Interaction and stability of mixed micelle and monolayer of nonionic and cationic surfactant mixtures
Sehgal, P., Kosaka, O., Doe, H. & Otzen, D., 2009, In: Journal of Dispersion Science and Technology. 30, p. 1050-1058Interaction of a potyviral VPg with anionic phospholipid vesicles
Rantalainen, K., Christensen, P. A., Hafrén, A., Otzen, D., Kalkkinen, N. & Mäkinen, K., 2009, In: Virology. 395, p. 114-120Interactions and Influence of a-Cyclodextrin on the Aggregation and Interfacial Properties of Mixtures of Nonionic and Zwitterionic Surfactants
Sehgal, P., Mizuki, T., Doe, H., Wimmer, R., Larsen, K. L. & Otzen, D., 2009, In: Colloid and Polymer Science. 287, p. 1243-1252Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan
Nesgaard, L. W., Vad, B., Christiansen, G. & Otzen, D., 2009, In: B B A - Molecular Cell Research. 1794, p. 84-93Proteasome-Fibrillation Antagonism in a Dynamic Model for Parkinson’s Disease
Sneppen, K., Lizana, G. L., Jensen, M. H., Pigolotti, S. & Otzen, D., 2009, In: Physical Biology. 6, p. 36005Proteomic changes in response to chromium(VI) toxicity in Pseudomonas aeruginosa
Kilic, N., Stensballe, A., Otzen, D. & Dönmez, G., 2009, In: Bioresource Technology. 101, p. 2134-2140Quantitative use of paramagnetic relaxation enhancements for determining orientation and insertion depth of peptides in micelles
Franzmann, M., Otzen, D. & Wimmer, R., 2009, In: ChemBioChem. 10, p. 2339-2347SAXS Study of Glucagon Fibrillation: From Monomers to Fibers
Oliveira, C. L. P. D., Behrens, M. A., Pedersen, J. S., Erlacher, K., Otzen, D. & Pedersen, J. S., 2009, In: Journal of Molecular Biology. 387, p. 147-161Stability and structure of the membrane protein transporter Ffh is modulated by substrates and lipids
Reinau, M. E. & Otzen, D., 2009, In: Archives of Biochemistry and Biophysics. 492, p. 48-53Stable intermediates determine proteins' primary unfolding sites in the presence of surfactants
Hansen, J. H., Petersen, S. V., Andersen, K. K., Enghild, J. J., Damhus, T. & Otzen, D., 2009, In: Biopolymers. 91, 3, p. 221-31 10 p.Surfactant protein SP-B strongly modifies surface collapse of phospholipid vesicles: Insights from a quartz crystal microbalance with dissipation
Cabré, E., Malmström, J., Sutherland, D., Perez-Gil, J. & Otzen, D., 2009, In: Biophysical Journal. 97, 3, p. 768-76 8 p.The influence of vesicle composition and size on a-synuclein structure and stability
Kjær, L., Giehm, L., Heimburg, T. R. & Otzen, D., 2009, In: Biophysical Journal. 96, 2857 p.The role of decorated SDS micelles in sub-cmc protein denaturation and association
Andersen, K., Oliveira, C. L. P. D., Larsen, K. L., Poulsen, F., Callisen, T., Westh, P., Pedersen, J. S. & Otzen, D., 2009, In: Journal of Molecular Biology. 391, p. 207-226Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy
Nielsen, J. T., Bjerring, M., Jeppesen, M., Pedersen, R. O., Pedersen, J. M., Hein, K. L., Vosegaard, T., Skrydstrup, T., Otzen, D. & Nielsen, N. C., 2009, In: Angewandte Chemie International Edition. 48, p. 2118-2121 4 p.Widespread abundance of Functional Bacterial Amyloid in Mycolata and other Gram positive Bacteria
Jensen, P. L., Dueholm, M. S., Larsen, P., Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H. & Otzen, D., 2009, In: Applied and Environmental Microbiology. 75, p. 4101-4110α-lactalbumin is unfolded by all classes of detergents but with different mechanisms
Otzen, D., Sehgal, P. & Westh, P., 2009, In: Journal of Colloid and Interface Science. 329, p. 273-283A global study of myoglobin-surfactant interactions
Andersen, K. K., Westh, P. & Otzen, D., 2008, In: Langmuir. 15, p. 399-407AFM-based force spectroscopy measurements of mature amyloid fibrils of the peptide glucagon: Nanotechnology
Dong, M. D., Hovgaard, M. B., Mamdouh, W., Xu, S. L., Otzen, D. E. & Besenbacher, F., 2008, In: Nanotechnology. 19, 38AFM-based force spectroscopy measurements of mature amyloid fibrils of the peptide glucagon
Dong, M., Hovgaard, M. B., Mamdouh, W., Xu, S., Otzen, D. & Besenbacher, F., 2008, In: Nanotechnology. 19, p. 384013 7 p.Aggregation of S6 in a quasi-native state by monomeric SDS
Otzen, D., Nesgaard, L., Andersen, K. K., Hansen, J. H., Christiansen, G., Doe, H. & Sehgal, P., 2008, In: B B A - Biomembranes. 1784, p. 400-414Amyloid - a state in many guises: survival of the fittest fibril fold
Pedersen, J. S. & Otzen, D., 2008, In: Protein Science. 17, p. 1-9Amyloid-like adhesins in floc-forming and filamentous bacteria in activated sludge
Larsen, P., Nielsen, J. L. & Otzen, D., 2008, In: Applied and Environmental Microbiology. 74, p. 1517-1526An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro
Haaning, S., Radutoiu, S., Hoffmann, S. V., Dittmer, J., Giehm, L., Otzen, D. & Stougaard, J., 2008, In: Journal of Biological Chemistry. 283, 45, p. 31142-52 10 p.Characterization of Dry Globular Proteins and Protein Fibrils by Synchrotron Radiation Vacuum UV Circular Dichroism
Nesgaard, L. W., Hoffmann, S. V., Andersen, C. B., Malmendal, A. & Otzen, D., 2008, In: Biopolymers. 89, 9, p. 779-795Dendrimers destabilize proteins in a generation-dependent manner involving eletrostatic interactions
Giehm, L., Christensen, C., Boas, U., Heegaard, P. M. H. & Otzen, D., 2008, In: Biopolymers. 89, p. 522-529Differential adsorption of variants of the thermomyces lanuginosus lipase on a hydrophobic surface suggests a role for local flexibility
Otzen, D., 2008, In: Colloids and Surfaces B: Biointerfaces. 64, p. 223-228Early Stages of Amyloid Fibril Formation Studied by Liquid-State NMR: The Peptide Hormone Glucagon
Svane, A. S. P., Jahn, K., Deva, T., Malmendal, A., Otzen, D., Dittmer, J. & Nielsen, N. C., 2008, In: Biophysical Journal. 95, 1, p. 366 – 377 11 p.Effect of glycosylation on biphysical and flocculative properties of the extracellular domain of Ag43
Knudsen, S. K., Westergaard, U. B., Frantzmann, M., Stensballe, A. & Otzen, D., 2008, In: Biochemical Journal. 412, p. 563-577Influence of beta-Cyclodextrin on the Mixed Micellization Process of Sodium Dodecyl Sulfate and Sodium Lauroyl Sarcosine and Formation of Inclusion Complexes
Sehgal, P., Sharma, D., Larsen, K. L., Wimmer, R., Otzen, D. & Doe, H., 2008, In: Journal of Dispersion Science and Technology. 29, p. 128-133Interactions of g-Cyclodextrin with the Mixed Micelles of Anionic Surfactants and Their Inclusion Complexes Formation
Sehgal, P., Sharma, M., Larsen, K. L., Wimmer, R., Doe, H. & Otzen, D., 2008, In: Journal of Dispersion Science and Technology. 29, p. 885-890Interactions of γ-Cyclodextrin with the Mixed Micelles of Anionic Surfactants and Their Inclusion Complexes Formation
Sehgal, P., Sharma, M., Larsen, K. L., Wimmer, R., Doe, H. & Otzen, D., 2008, In: Journal of Dispersion Science and Technology. 29, p. 885-890Spectroscopic Evidence for the Existence of an Obligate Pre-Fibrillar Oligonomer during Glucagon Fibrillation
Christensen, P. A., Pedersen, J. S., Christiansen, G. & Otzen, D., 2008, In: F E B S Letters. 582, p. 1341-1345Thermodynamics and mechanism of cutinase stabilization by trehalose
Baptista, R. P., Pedersen, S. H., Cabrita, G. J. M., Otzen, D., Cabral, J. M. & Melo, E. P., 2008, In: Biopolymers. 89, p. 538-547We find them here, we find them there: Functional bacterial amyloid
Otzen, D. & Nielsen, P. H., 2008, In: Cellular and Molecular Life Sciences. 65, p. 910-927p25α relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy
Song, Y. J. C., Lundvig, D. M. S., Huang, Y., Wei, P. G., Blumbergs, P. C., Højrup, P., Otzen, D., Halliday, G. M. & Jensen, P. H., Oct 2007, In: American Journal of Pathology. 171, 4, p. 1291-1303 13 p.Heparin binding induces a conformational change in pigment epithelium-derived factor
Valnickova, Z., Petersen, S. V., Nielsen, S. B., Otzen, D. E. & Enghild, J. J., 2 Mar 2007, In: Journal of Biological Chemistry. 282, 9, p. 6661-6667 7 p.Alternative membrane protein conformations in alcohol
Otzen, D., Sehgal, P. & Nesgaard, L., 2007, In: Biochemistry. 46, p. 4348-4359Amyloid adhesins are abundant in natural biofilms
Larsen, P., Dueholm, M. S., Christiansen, G., Nielsen, J. L., Otzen, D. & Nielsen, P. H., 2007, In: Env. Microbiol.. 9, p. 3077-3090Changes in structures of milk proteins upon photo-oxidation
Dalsgaard, T. K., Otzen, D., Nielsen, J. H. & Larsen, L. B., 2007, In: J. Agr. Food Chem.. 55, p. 10968-10976Dendrimer effects on peptide and protein fibrillation
Heegaard, P. M. P., Boas, U. & Otzen, D., 2007, In: Macromolecular Bioscience. 7, p. 1047-1059Heparin binding induces a conformational change of pigment epithelium-derived factor (PEDF).
Valnickova, Z., Petersen, S. V., Nielsen, SB., Otzen, D. & Enghild, J. J., 2007, In: Journal of Biological Chemistry.Modulation of cutinase structure and stability by phospholipid detergents
Sehgal, P., Bang Nielsen, S., Pedersen, S., Wimmer, R. & Otzen, D., 2007, In: Biochim. Biophys. Acta.. 1774, p. 1544-1554Quartz crystal microbalance studies of multilayer glucagon fibrillation at the solid-liquid interface
Hovgaard, M. B., Dong, M., Otzen, D. E. & Besenbacher, F., 2007, In: Biophysical Journal. 93, 6, p. 2162-9 7 p.Quartz crystal microbalance studies of multilayer glucagons fibrillation at the solid-liquid interface
Hovgaard, M. B., Dong, M., Otzen, D. & Besenbacher, F., 2007, In: Biophysical Journal. 93, 6, p. 2162The Major Allergen from Birch Tree Pollen, Bet v 1, Binds and Permeabilizes Membranes.
Morgensen, JE., Ferreras, M., Wimmer, R., Petersen, S. V., Enghild, J. J. & Otzen, D., 2007, In: Biochemistry.Unfolding of ß-sheet proteins in SDS
Nielsen, M. M., Andersen, K. K., Westh, P. & Otzen, D., 2007, In: Biophysical Journal. 92, p. 3674-3685We find them here, we find them there: Functional bacterial amyloid
Otzen, D. & Nielsen, P. H., 2007, In: Cell. Mol. Life Sci..p25a Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy
Song, Y. J. C., Lundvig, D. M. S., Huang, Y., Gai, W. P., Blumbergs, P. C., Højrup, P., Otzen, D., Halliday, G. M. & Jensen, P. H., 2007, In: Am. J. Path.. 171, p. 1291-1303Interactions between anionic mixed micelles and α-cyclodextrin and their inclusion complexes: conductivity, NMR and fluorescence study
Sehgal, P., Sharma, M., Wimmer, R., Larsen, K. L. & Otzen, D., 2006, In: Colloid and Polymer Science. 284, 8, p. 916-926N- and C-Terminal Hydrophobic Patches Are Involved in Fibrillation of Glucagon
Pedersen, J. S., Dikov, D. & Otzen, D., 2006, In: Biochemistry. 45, 48, p. 14503-14512 10 p.Sulfates Dramatically Stabilize a Salt-Dependent Type of Glucagon Fibrils
Pedersen, J. S., Flink, J. M., Dikov, D. & Otzen, D., 2006, In: Biophysical Journal. 90, 11, p. 4181-4194Thermodynamics of unfolding of an integral membrane protein in mixed micelles
Sehgal, P. & Otzen, D., 2006, In: Protein Science. 15, p. 890-899Antagonism, non-native interactions and non-two-state folding in S6 revealed by double-mutant cycle analysis
Otzen, D., 1 Nov 2005, In: Protein Engineering, Design and Selection. 18, 11, p. 547-557 11 p.Synergistic behavior of sodiumdodecylsulfate and 1,2-diheptanoyl-sn- glycero-3-phosphocholine in an aqueous medium: Interfacial and bulk behavior
Sehgal, P., Doe, H., Sharma, M. & Otzen, D. E., 1 Aug 2005, In: Colloid and Polymer Science. 283, 11, p. 1219-1225 7 p.Interactions between folding factors and bacterial outer membrane proteins
Mogensen, J. E. & Otzen, D. E., 1 Jul 2005, In: Molecular Microbiology. 57, 2, p. 326-346 21 p.Conformational detours during folding of a collapsed state
Otzen, D. E., 30 Jun 2005, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1750, 2, p. 146-153 8 p.Activation, Inhibition, and Destabilization of Thermomyces lanuginosus Lipase by Detergents
Mogensen, J. E., Sehgal, P. & Otzen, D., 2005, In: Biochemistry. 44, 5, p. 1719-1730Barriers to Folding of the Transmembrane Domain of the Escherichia coli Autotransporter Adhesin Involved in Diffuse Adherence
Mogensen, J. E., Tapadar, D., Schmidt, M. A. & Otzen, D., 2005, In: Biochemistry. 44, p. 4533-4545Misfolding of a bacterial autotransporter
Mogensen, J. E., Kleinschmidt, J. H., Schmidt, M. A. & Otzen, D., 2005, In: Protein Science. 14, p. 2814-2827Protein drug stability: a formulation challenge
Frøkjær, S. & Otzen, D., 2005, In: Nature Reviews. Drug Discovery. 4, p. 298-306Stabilization of the Ribosomal Protein S6 by Trehalose is Counterbalanced by the Formation of a Putative Off-pathway Species
Chen, L., Cabrita, G. J. M., Otzen, D. & Melo, E. P., 2005, In: Journal of Molecular Biology. 351, p. 402-416Using micellar mole fractions to assess membrane protein stability in mixed micelles
Sehgal, P., Mogensen, J. E. & Otzen, D., 2005, In: B B A - Biomembranes. 1761, p. 59-68 10 p.Correspondence between anomalous m- and ΔCp-values in protein folding
Otzen, D. E. & Oliveberg, M., 1 Dec 2004, In: Protein Science. 13, 12, p. 3253-3263 11 p.Investigating porcine pancreatic phospholipase A 2 action on vesicles and supported planar bilayers using a quartz crystal microbalance with dissipation
Justesen, P. H., Kristensen, T., Ebdrup, T. & Otzen, D., 15 Nov 2004, In: Journal of Colloid and Interface Science. 279, 2, p. 399-409 11 p.Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein
Otzen, D. E., Miron, S., Akke, M. & Oliveberg, M., 19 Oct 2004, In: Biochemistry. 43, 41, p. 12964-12978 15 p.Modulation of S6 fibrillation by unfolding rates and gatekeeper residues
Pedersen, J. S., Christensen, G. & Otzen, D. E., 6 Aug 2004, In: Journal of Molecular Biology. 341, 2, p. 575-588 14 p.Interaction between phospholipid vesicular structures with long chain zwitterionic surfactants
Sehgal, P., Doe, H., Sharma, M. & Otzen, D. E., 1 May 2004, In: Colloid and Polymer Science. 282, 7, p. 677-683 7 p.Transient formation of nano-crystalline structures during fibrillation of an Aβ-like peptide
Otzen, D. E. & Oliveberg, M., 1 May 2004, In: Protein Science. 13, 5, p. 1417-1421 5 p.Elimination of A Misfolded Folding Intermediate by A Single Point Mutation
Mogensen, J. E., Ipsen, H., Holm, J. & Otzen, D. E., 30 Mar 2004, In: Biochemistry. 43, 12, p. 3357-3367 11 p.Structural background of cyclodextrin-protein interactions
Aachmann, F. L., Otzen, D. E., Larsen, K. L. & Wimmer, R., 1 Dec 2003, In: Protein Engineering. 16, 12, p. 905-912 8 p.Trehalose favors a cutinase compact intermediate off-folding pathway
Melo, E. P., Chen, L. Y., Cabral, J. M. S., Fojan, P., Petersen, S. B. & Otzen, D. E., 24 Jun 2003, In: Biochemistry. 42, 24, p. 7611-7617 7 p.Adsorption of a small protein to a methyl-terminated hydrophobic surfaces: Effect of protein-folding thermodynamics and kinetics
Otzen, D. E., Oliveberg, M. & Höök, F., 15 May 2003, In: Colloids and Surfaces B: Biointerfaces. 29, 1, p. 67-73 7 p.Folding of DsbB in mixed micelles: a kinetic analysis of the stability of a bacterial membrane protein.
Otzen, D. E., 1 Jan 2003, In: Journal of Molecular Biology. 330, 4, p. 641-649 9 p.Protein unfolding in detergents: Effect of micelle structure, ionic strength, pH, and temperature
Otzen, D. E., 1 Oct 2002, In: Biophysical Journal. 83, 4, p. 2219-2230 12 p.Structural basis for cyclodextrins' suppression of human growth hormone aggregation
Otzen, D. E., Knudsen, B. R., Aachmann, F., Larsen, K. L. & Wimmer, R., 2 Jul 2002, In: Protein Science. 11, 7, p. 1779-1787 9 p.The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands
Mogensen, J. E., Wimmer, R., Larsen, J. N., Spangfort, M. D. & Otzen, D. E., 28 Jun 2002, In: Journal of Biological Chemistry. 277, 26, p. 23684-23692 9 p.Burst-phase expansion of native protein prior to global unfolding in SDS
Otzen, D. E. & Oliveberg, M., 1 Jan 2002, In: Journal of Molecular Biology. 315, 5, p. 1231-1240 10 p.Conformational plasticity in folding of the split β-α-β protein S6: Evidence for burst-phase disruption of the native state
Otzen, D. E. & Oliveberg, M., 1 Jan 2002, In: Journal of Molecular Biology. 317, 4, p. 613-627 15 p.Folding of circular permutants with decreased contact order: General trend balanced by protein stability
Lindberg, M. O., Tångrot, J., Otzen, D. E., Dolgikh, D. A., Finkelstein, A. V. & Oliveberg, M., 7 Dec 2001, In: Journal of Molecular Biology. 314, 4, p. 891-900 10 p.A simple way to measure protein refolding rates in water
Otzen, D. E. & Oliveberg, M., 26 Oct 2001, In: Journal of Molecular Biology. 313, 3, p. 479-483 5 p.Stability and Folding of Endoglucanase I (CEL7B) from Humicoia Insolens
Otzen, D. & Schülein, M., 1 Jan 2001, In: Biocatalysis and Biotransformation. 19, 42130, p. 469-487 19 p.Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: A structural clue to amyloid assembly
Otzen, D. E., Kristensen, O. & Oliveberg, M., 29 Aug 2000, In: Proceedings of the National Academy of Sciences. 97, 18, p. 9907-9912 6 p.Model process for separation based on unfolding and refolding of chymotrypsin inhibitor 2 in thermoseparating polymer two-phase systems
Umakoshi, H., Persson, J., Kroon, M., Johansson, H. O., Otzen, D. E., Kuboi, R. & Tjerneld, F., 23 Jun 2000, In: Journal of Chromatography B: Biomedical Sciences and Applications. 743, 1-2, p. 13-19 7 p.The spectral and thermodynamic properties of staphylococcal enterotoxin A, E, and variants suggest that structural modifications are important to control their function
Cavallin, A., Arozenius, H., Kristensson, K., Antonsson, P., Otzen, D. E., Björk, P. & Forsberg, G., 21 Jan 2000, In: Journal of Biological Chemistry. 275, 3, p. 1665-1672 8 p.Salt-induced detour through compact regions of the protein folding landscape
Otzen, D. E. & Oliveberg, M., 12 Oct 1999, In: Proceedings of the National Academy of Sciences. 96, 21, p. 11746-11751 6 p.Electrostatics in the active site of an α-amylase
Nielsen, J. E., Beier, L., Otzen, D., Borchert, T. V., Frantzen, H. B., Andersen, K. V. & Svendsen, A., 15 Sept 1999, In: European Journal of Biochemistry. 264, 3, p. 816-824 9 p.Structural changes in the transition state of protein folding: Alternative interpretations of curved chevron plots
Otzen, D. E., Kristensen, O., Proctor, M. & Oliveberg, M., 18 May 1999, In: Biochemistry. 38, 20, p. 6499-6511 13 p.Analysis of protein-protein interactions by mutagenesis: Direct versus indirect effects
Otzen, D. E. & Fersht, A. R., 2 Feb 1999, In: Protein Engineering. 12, 1, p. 41-45 5 p.A comparative study of the unfolding of the endoglucanase Ce145 from Humicola insolens in denaturant and surfactant
Otzen, D. E., Christiansen, L. & Schülein, M., 1 Jan 1999, In: Protein Science. 8, 9, p. 1878-1887 10 p.Properties of PEG-modified microbial proteases. Activity and stability studies
Fatum, T. M., Olsen, A. A., Fuglsang, C. C. & Otzen, D., 1 Dec 1998, In: Progress in Biotechnology. 15, C, p. 147-150 4 p.Folding of circular and permuted chymotrypsin inhibitor 2: Retention of the folding nucleus
Otzen, D. E. & Fersht, A. R., 2 Jun 1998, In: Biochemistry. 37, 22, p. 8139-8146 8 p.Enzymatic characterisation of novamyl®, a thermostable α-amylase
Christophersen, C., Otzen, D. E., Norman, B. E., Christensen, S. & Schäfer, T., 1 Jan 1998, In: Starch/Staerke. 50, 1, p. 39-45 7 p.Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis
Neira, J. L., Itzhaki, L. S., Otzen, D. E., Davis, B. & Fersht, A. R., 4 Jul 1997, In: Journal of Molecular Biology. 270, 1, p. 99-110 12 p.Rate of isomerisation of peptidyl-proline bonds as a probe for interactions in the physiological denatured state of chymotrypsin inhibitor 2
Tan, Y. J., Oliveberg, M., Otzen, D. E. & Fersht, A. R., 20 Jun 1997, In: Journal of Molecular Biology. 269, 4, p. 611-622 12 p.Structure of the transition state for folding of a protein derived from experiment and simulation
Daggett, V., Li, A., Itzhaki, L. S., Otzen, D. E. & Fersht, A. R., 29 Mar 1996, In: Journal of Molecular Biology. 257, 2, p. 430-440 11 p.Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway
De Prat Gay, G., Ruiz-Sanz, J., Neira, J. L., Corrales, F. J., Otzen, D. E., Ladurner, A. G. & Fersht, A. R., 15 Dec 1995, In: Journal of Molecular Biology. 254, 5, p. 968-979 12 p.The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: Evidence for a nucleation-condensation mechanism for protein folding
Itzhaki, L. S., Otzen, D. E. & Fersht, A. R., 24 Nov 1995, In: Journal of Molecular Biology. 254, 2, p. 260-288 29 p.Side-Chain Determinants of β-Sheet Stability
Otzen, D. E. & Fersht, A. R., 1 May 1995, In: Biochemistry. 34, 17, p. 5718-5724 7 p.Movement of the Position of the Transition State in Protein Folding
Matouschek, A., Otzen, D. E., Itzhaki, L. S., Jackson, S. E. & Fersht, A. R., 1 Jan 1995, In: Biochemistry. 34, 41, p. 13656-13662 7 p.Nature and Consequences of GroEL-Protein Interactions
Itzhaki, L. S., Otzen, D. E. & Fersht, A. R., 1 Jan 1995, In: Biochemistry. 34, 44, p. 14581-14587 7 p.Protein Fragments as Models for Events in Protein Folding Pathways: Protein Engineering Analysis of the Association of Two Complementary Fragments of the Barley Chymotrypsin Inhibitor 2 (CI-2)
Ruiz-Sanz, J., de Prat Gay, G., Otzen, D. E. & Fersht, A. R., 1 Jan 1995, In: Biochemistry. 34, 5, p. 1695-1701 7 p.Structural Factors Contributing to the Hydrophobic Effect: The Partly Exposed Hydrophobic Minicore in Chymotrypsin Inhibitor
Otzen, D. E., Rheinnecker, M. & Fersht, A. R., 1 Jan 1995, In: Biochemistry. 34, 40, p. 13051-13058 8 p.Single versus parallel pathways of protein folding and fractional formation of structure in the transition state
Fersht, A. R., Itzhaki, L. S., Elmasry, N. F., Matthews, J. M. & Otzen, D. E., 25 Oct 1994, In: Proceedings of the National Academy of Sciences. 91, 22, p. 10426-10429 4 p.Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding
Otzen, D. E., Itzhaki, L. S., Elmasry, N. F., Jackson, S. E. & Fersht, A. R., 25 Oct 1994, In: Proceedings of the National Academy of Sciences. 91, 22, p. 10422-10425 4 p.Dual hydrolytic role for Pb(II) ions
Otzen, D. E., Barciszewski, J. & Clark, B. F. C., 1 Jan 1994, In: Biochimie. 76, 1, p. 15-21 7 p.Altered lead(II)-cleavage pattern of free Phe-tRNA(Phe) and Phe-tRNA(Phe) in ternary complex with EF-Tu:GTP
Otzen, D. E., Barciszewski, J. & Clark, B. F. C., 1 Jan 1993, In: Biochemistry and Molecular Biology International. 31, 1, p. 95-103 9 p.Reduction in the amount of 8-hydroxy-2´-deoxyguanosine in the DNA of SV40-transformed human fibroblasts as compared with normal cells in culture.
Barciszewski, J., Rattan, S., Siboska, G., Otzen, D. & Clark, B. F. C., 1993, In: F E B S Letters. 318, p. 186-188Specific incorporation of kinetin into eukaryotic and prokaryotic transfer ribonucleic acid molecules
Barciszewski, J., Otzen, D., Rattan, S. I. S. & Clark, B. F. C., 1 Dec 1992, In: Biochemistry international. 28, 5, p. 805-811 7 p.Specific incorportation of kinetin into eukaryotic and prokaryotic transfer ribonucleic acid molecules.
Barciszewski, J., Rattan, S., Otzen, D. & Clark, B. F. C., 1992, In: Biochemistry international. 28, p. 805-811