Daniel Erik Otzen

Research output

Research output per year 1992 2008 2009 2010 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2024 2024

• 395 Journal article
• 11 Review
• 10 Book chapter
• 7 Conference abstract for conference
• 12 More
  • 5 Conference abstract in journal
  • 4 Poster
  • 2 Editorial
  • 1 Comment/debate/letter to the editor

Research output per year

Research output per year

Search results

• 2024

  Antibodies and α-synuclein: What to target against Parkinson's Disease?

  Otzen, D. E., Feb 2024, In: B B A - Proteins and Proteomics. 1872, 2, 140943.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Monospecific Antibody 100%
  • Synuclein 100%
  • Parkinson's Disease 100%
  • Clinical Trial 66%
  • Intrinsically Disordered Protein 33%

• A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion

  Santos, J., Cuellar, J., Pallarès, I., Byrd, E. J., Lends, A., Moro, F., Abdul-Shukkoor, M. B., Pujols, J., Velasco-Carneros, L., Sobott, F., Otzen, D. E., Calabrese, A. N., Muga, A., Pedersen, J. S., Loquet, A., Valpuesta, J. M., Radford, S. E. & Ventura, S., May 2024, In: Journal of the American Chemical Society. 146, 18, p. 12702-12711 10 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • N-Terminus 100%
  • Synuclein 100%
  • Modulin 37%
  • Conformation 12%
  • Amyloid 12%

• BBA: 2024 and beyond

  Otzen, D. & d'Angelo, J., Feb 2024, In: Biochimica et Biophysica Acta - General Subjects. 1868, 2, 130524.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review

• Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases

  Pirhaghi, M., Mamashli, F., Moosavi-Movahedi, F., Arghavani, P., Amiri, A., Davaeil, B., Mohammad-Zaheri, M., Mousavi-Jarrahi, Z., Sharma, D., Langel, Ü., Otzen, D. E. & Saboury, A. A., May 2024, In: Molecular Pharmaceutics. 21, 5, p. 2097-2117 21 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

  • Drug Delivery System 100%
  • Cell Penetrating Peptide 100%
  • Degenerative Disease 100%
  • Nanoparticle 50%
  • Parkinson's Disease 50%

• CsgA gatekeeper residues control nucleation but not stability of functional amyloid

  Olsen, W. P., Courtade, G., Peña-Díaz, S., Nagaraj, M., Sønderby, T. V., Mulder, F. A. A., Malle, M. G. & Otzen, D. E., Oct 2024, In: Protein Science. 33, 10, 18 p., e5178.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Residue Control 100%
  • CsgA 100%
  • Gatekeeper Residue 100%
  • Nucleation 100%
  • Amyloid Protein 100%

• Extracellular G-quadruplexes and Z-DNA protect biofilms from DNase I, and G-quadruplexes form a DNAzyme with peroxidase activity

  Minero, G. A. S., Møllebjerg, A., Thiesen, C., Johansen, M. I., Jørgensen, N. P., Birkedal, V., Otzen, D. E. & Meyer, R. L., Feb 2024, In: Nucleic Acids Research. 52, 4, p. 1575-1590 16 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Biofilm 100%
  • Nuclease 31%
  • DNA Structure 25%
  • Extracellular Matrix 12%
  • Immunolabeling 6%

• Functional Amyloids: The Biomaterials of Tomorrow?

  Peña-Díaz, S., Olsen, W. P., Wang, H. & Otzen, D. E., 2 May 2024, In: Advanced Materials. 36, 18, 2312823.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Biomaterial 100%
  • Nanoparticle 50%
  • Biofilms 50%
  • Hydrogel 50%

• Functional porous protein nanofibrils/polysaccharides aerogel beads for efficient dyes removal from water

  Dilamian, M., Montazer, M., Yousefi, H., Otzen, D. E. & Morshedi, D., Jun 2024, In: Materials Advances. 5, 18, p. 7199-7221 23 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Dye Removal 100%
  • Polysaccharide Aerogel 100%
  • Aerogel Beads 100%
  • Protein Nanofibrils 100%
  • Polysaccharide 100%

• Helping proteins come in from the cold: 5 burning questions about cold-active enzymes

  Nowak, J. S. & Otzen, D. E., 2024, In: BBA advances. 5, 100104.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

  Open Access

  • Big Data 100%
  • Bright Futures 100%
  • Enzyme 100%

• Hvordan opnår vi en bæredygtig plastikkultur?

  Otzen, D. E., Møllebjerg, A., Hinge, M. & Pathak, G. S., 2024, In: Aktuel Naturvidenskab. 2024, 1, p. 15-18

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication

• Impact of hydrolysis method and lactase preparation on proteolysis and glycation in long-term stored lactose-hydrolysed UHT milk

  Knudsen, L. J., Nielsen, S.D.-H., Dekker, P., Otzen, D. E., Rauh, V. & Larsen, L. B., Jul 2024, In: International Dairy Journal. 154, 11 p., 105946.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research

  Open Access

  • Milk Protein 100%
  • Maillard Reaction 100%

• Insight into protein cross-linking and casein polymerization in pre- and post-hydrolyzed lactose-free UHT milk during long-term storage

  Knudsen, L. J., Rauh, V., Pedersen, J. N., Dekker, P., Otzen, D. E., Larsen, L. B. & Nielsen, S.D.-H., 10 Sept 2024, (E-pub ahead of print) In: Journal of Dairy Science.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Protein Cross-linking 100%
  • Dehydroalanine 28%
  • Lactase Enzyme 28%
  • Milk Type 14%
  • Large Particle 14%

• Mining and engineering activity in catalytic amyloids

  Peña-Díaz, S., Ferreira, P., Ramos, M. J. & Otzen, D. E., 2024, In: Methods in Enzymology. 697, p. 345-422 78 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Amyloid 100%
  • Surface Property 14%
  • Tau 14%
  • Active Site 14%
  • Enzyme 14%

• Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers

  Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K., Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S., Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J. & Nielsen, M. A. & 3 others, Sander, A. F., Romero-Ramos, M. & Otzen, D. E., Jun 2024, In: npj Parkinson's Disease . 10, 1, 139.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Monoclonal Antibody 100%
  • Oligomer 100%
  • Synuclein 100%
  • Fibril 20%
  • Postmortem Brain 20%

• Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

  Adam, L., Kumar, R., Arroyo-Garcia, L. E., Molenkamp, W. H., Nowak, J. S., Klute, H., Farzadfard, A., Alkenayeh, R., Nielsen, J., Biverstål, H., Otzen, D. E., Johansson, J. & Abelein, A., Aug 2024, In: Protein Science. 33, 8, 17 p., e5091.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Oligomer 100%
  • Synuclein 100%
  • Chaperone 100%
  • BRICHOS 100%
  • Nucleation 66%

• Structure-Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid-β Aggregation

  Žvirblis, M., Sakalauskas, A., Janvand, S. H. A., Dudutienė, V., Žiaunys, M., Sniečkutė, R., Otzen, D. E., Smirnovas, V. & Matulis, D., 7 Aug 2024, (E-pub ahead of print) In: Chemistry - A European Journal. p. e202402330

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Structure Activity Relationship 100%
  • Amyloid 100%
  • Amyloid Beta Protein 100%
  • Beta-Amyloid 100%
  • Structure-Activity Relationship 100%

• The impact of hUC MSC-derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity

  Aliakbari, F., Marzookian, K., Parsafar, S., Hourfar, H., Nayeri, Z., Fattahi, A., Raeiji, M., Boroujeni, N. N., Otzen, D. E. & Morshedi, D., 5 Apr 2024, In: Science Advances. 10, 14, p. eadl3406 eadl3406.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Stem Cell 100%
  • Nanoliposome 100%
  • Synuclein 100%
  • Oleuropein 50%
  • Membrane Lipid 25%

• Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

  Monti, M., Milanetti, E., Frans, M. T., Miotto, M., Di Rienzo, L., Baranov, M. V., Gosti, G., Somavarapu, A. K., Nagaraj, M., Golbek, T. W., Rossing, E., Moons, S. J., Boltje, T. J., van den Bogaart, G., Weidner, T., Otzen, D. E., Tartaglia, G. G., Ruocco, G. & Roeters, S. J., 18 Jan 2024, In: The journal of physical chemistry. B. 128, 2, p. 451-464 14 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • N-Terminus 100%
  • Sialic Acid 100%
  • Receptor Binding 100%
  • Spike 100%
  • Severe Acute Respiratory Syndrome 100%
• 2023

  4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation

  Andersen, C. B., Lausdahl, A. K., Nielsen, J., Clausen, M. P., Mulder, F. A. A., Otzen, D. E. & Arnspang, E. C., Aug 2023, In: Biochemistry. 62, 16, p. 2417-2425 9 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Confocal Microscopy 100%
  • Lipid Peroxidation 100%
  • Synuclein 100%
  • Intrinsically Disordered Protein 50%
  • Retromer 50%

• Alzheimer's Progenitor Amyloid-β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function

  Ali, S. A., Chung, K. H. K., Forgham, H., Olsen, W. P., Kakinen, A., Balaji, A., Otzen, D. E., Davis, T. P. & Javed, I., Oct 2023, In: Advanced Science. 10, 29, 16 p., e2301423.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Amyloid 100%
  • Biofilm 100%
  • Fibril 100%
  • Alzheimer's Disease 50%
  • Monomer 50%

• Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

  Somavarapu, A. K., Kleijwegt, G., Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E., Mar 2023, In: Chemical Science. 14, 11, p. 3030-3047 18 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Oligomer 100%
  • Membrane Damage 100%
  • Synuclein 100%
  • Drug Repositioning 100%
  • Molecular Library 100%

• Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

  Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T., Sept 2023, In: Nature Communications. 14, 1, 12 p., 5731.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Lipid 100%
  • Conformation 100%
  • Alpha-Synuclein 100%
  • Membrane Lipid 75%
  • Amyloid 50%

• FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC

  Rasmussen, H. Ø., Kumar, A., Shin, B., Stylianou, F., Sewell, L., Xu, Y., Otzen, D. E., Pedersen, J. S. & Matthews, S. J., Jan 2023, In: Journal of Molecular Biology. 435, 2, 18 p., 167878.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Pseudomonas 100%
  • Fibril 100%
  • Amyloid 100%
  • Biofilm 75%
  • Molecular Interaction 25%

• GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureusreveal surface-associated coagulase in biofilms

  Evans, D. C. S., Khamas, A. B., Marcussen, L., Rasmussen, K. S., Klitgaard, J. K., Kallipolitis, B. H., Nielsen, J., Otzen, D. E., Leake, M. C. & Meyer, R. L., Jul 2023, In: Microbial Cell. 10, 7, p. 145-156 12 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Staphylococcus aureus 100%
  • Coagulase 100%
  • Arginine 40%
  • Twin-Arginine Translocation Pathway 20%

• Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation

  Alijanvand, S. H., Ladefoged, L. K., Zubrienė, A., Sakalauskas, A., Christiansen, G., Dudutiene, V., Schiøtt, B., Matulis, D., Smirnovas, V. & Otzen, D. E., Feb 2023, In: International Journal of Biological Macromolecules. 227, p. 590-600 11 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Sulfonamide 100%
  • Amyloid 100%
  • Disease 50%
  • Carbonate Dehydratase 50%
  • Carbonic Anhydrase 50%

• Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

  Singh, Y., Trautwein, C., Romani, J., Salker, M. S., Neckel, P. H., Fraccaroli, I., Abeditashi, M., Woerner, N., Admard, J., Dhariwal, A., Dueholm, M. K. D., Schäfer, K. H., Lang, F., Otzen, D. E., Lashuel, H. A., Riess, O. & Casadei, N., Jul 2023, In: Molecular Neurodegeneration. 18, 1, 44.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Parkinson's Disease 100%
  • Gut 100%
  • Alpha Synuclein 100%
  • Metabolite 100%
  • Microbiome 100%

• Periostin C-Terminal Is Intrinsically Disordered and Interacts with 143 Proteins in an In Vitro Epidermal Model of Atopic Dermatitis

  Rusbjerg-Weberskov, C. E., Johansen, M. L., Nowak, J. S., Otzen, D., Pedersen, J. S., Enghild, J. J. & Nielsen, N. S., Sept 2023, In: Biochemistry. 62, 19, p. 2803-2815 13 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

• Proteins and biosurfactants: Structures, functions, and recent applications

  López Hernández, M., Pedersen, J. S. & Otzen, D. E., Dec 2023, In: Current Opinion in Colloid and Interface Science. 68, 101746.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

  Open Access

  • Surface Active Agent 100%
  • Self Assembly 50%
  • Critical Micelle Concentration 25%

• Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation

  Sønderby, T. V., Louros, N. N., Khodaparast, L., Khodaparast, L., Madsen, D. J., Olsen, W. P., Moonen, N., Nagaraj, M., Sereikaite, V., Strømgaard, K., Rousseau, F., Schymkowitz, J. & Otzen, D. E., 1 Jun 2023, In: Journal of Molecular Biology. 435, 11, p. 168039 168039.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Biofilm Formation 100%
  • Structure 100%
  • Primary Structure 100%
  • Biofilm 100%
  • Amyloid 100%

• Tau Fibrillation Induced by Heparin or a Lysophospholipid Show Different Initial Oligomer Formation

  Rasmussen, H. Ø., Nielsen, J., de Poli, A., Otzen, D. E. & Pedersen, J. S., Sept 2023, In: Journal of Molecular Biology. 435, 17, 18 p., 168194.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Oligomer 100%
  • Heparin 100%
  • Liquefied Petroleum Gas 100%
  • Structure 33%
  • Micelle 33%

• The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity

  Pirhaghi, M., Najarzadeh, Z., Moosavi-Movahedi, F., Shafizadeh, M., Mamashli, F., Atarod, D., Ghasemi, A., Morshedi, D., Meratan, A. A., Otzen, D. E. & Saboury, A. A., Feb 2023, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1871, 2, 14 p., 140883.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Antibiotics 100%
  • Antithrombocytic Agent 100%
  • Ticlopidine 100%
  • Methicillin-Resistant Staphylococcus Aureus 40%
  • Pseudomonas aeruginosa 40%

• The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells

  Hourfar, H., Aliakbari, F., Aqdam, S. R., Nayeri, Z., Bardania, H., Otzen, D. E. & Morshedi, D., Feb 2023, In: International Journal of Biological Macromolecules. 229, p. 305-320 16 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Blood Brain Barrier 100%
  • Synuclein 100%
  • Blood-Brain Barrier 100%
  • Astrocyte 60%
  • Coculture 40%

• Transdisciplinary Pragmatic Melioration for the Plastic Life Cycle: Why the Social, Natural, and Technical Sciences Should Prioritize Reducing Harm

  Pathak, G. S., Hinge, M. & Otzen, D., Oct 2023, In: Science of the Total Environment. 895, 9 p., 165154.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

  Open Access

  • Life Cycle 100%
  • Transdisciplinary 100%
  • Lifecycle 100%
  • Processing Equipment 100%
  • Recycling 50%
• 2022

  Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells

  He, J., Steffen, J. H., Thulstrup, P. W., Pedersen, J. N., Sauerland, M. B., Otzen, D. E., Hawkins, C. L., Gourdon, P., Davies, M. J. & Hägglund, P., Dec 2022, In: Scientific Reports. 12, 1, 15 p., 22051.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Smooth Muscle Cell 100%
  • Fibronectin 100%
  • Coronary Artery 100%
  • Extracellular Matrix 100%
  • Cytokine 100%

• A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers

  Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaite, V., Gupta, A., Strømgaard, K., Andreasen, M., Sharma, D., Saboury, A. A. & Otzen, D. E., Dec 2022, In: Journal of Biological Chemistry. 298, 12, 102688.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Cytotoxicity 100%
  • Oligomer 100%
  • Synuclein 100%
  • Penetratin 100%
  • Parkinson's Disease 66%

• A Protein Corona Modulates Interactions of α-Synuclein with Nanoparticles and Alters the Rates of the Microscopic Steps of Amyloid Formation

  Mohammad-Beigi, H., Zanganeh, M., Scavenius, C., Eskandari, H., Farzadfard, A., Shojaosadati, S. A., Enghild, J. J., Otzen, D. E., Buell, A. K. & Sutherland, D. S., Jan 2022, In: ACS Nano. 16, 1, p. 1102-1118 17 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Surface Property 100%
  • Amyloid 100%
  • Synuclein 100%
  • Nanoparticle 100%
  • Protein Corona 100%

• A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL

  Kjærgaard, M., Rasmussen, L. S., Vinther, J. N., Andersen, K. R., Andersen, E. S., Lorentzen, E., Thirup, S. S., Otzen, D. & Brodersen, D. E., Dec 2022, In: The Biophysicist. 3, 2, p. 106–114 9 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

• Bidirectional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners

  Christensen, N. R., Pedersen, C. P., Sereikaite, V., Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T., Otzen, D., Teilum, K., Madsen, K. L. & Strømgaard, K., Feb 2022, In: iScience. 25, 2, 26 p., 103808.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Phase Separation 100%
  • Protein-Protein Interaction 100%
  • Postsynaptic Density 100%
  • AMPA Receptor 28%
  • C-Terminus 14%

• Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation

  Nagaraj, M., Najarzadeh, Z., Pansieri, J., Biverstål, H., Musteikyte, G., Smirnovas, V., Matthews, S., Emanuelsson, C., Johansson, J., Buxbaum, J. N., Morozova-Roche, L. & Otzen, D. E., Jan 2022, In: Chemical Science. 13, 2, p. 536-553 18 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Biofilm 100%
  • Nucleation 100%
  • Amyloid 100%
  • Chaperone 100%
  • Pseudomonas 33%

• Characterization of exogenous αSN response genes and their relation to Parkinson's disease using network analyses

  Nayeri, Z., Aliakbari, F., Afzali, F., Parsafar, S., Gharib, E., Otzen, D. E. & Morshedi, D., 2022, In: Frontiers in Pharmacology. 13, 14 p., 966760.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Tumor Necrosis Factor 100%
  • Parkinson's Disease 100%
  • DUSP1 50%
  • Small Molecule 50%
  • Gene Expression 50%

• EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers

  Grønnemose, A. L., Østerlund, E. C., Otzen, D. E. & Jørgensen, T. J. D., Dec 2022, In: Journal of Molecular Biology. 434, 23, 167855.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  File

  • N-Terminus 100%
  • Synuclein 100%
  • Epigallocatechin Gallate 100%
  • Alpha Oxidation 22%
  • Hydrogen/Deuterium Exchange Mass Spectrometry 22%
  25 Downloads (Pure)

• Folding steps in the fibrillation of functional amyloid: denaturant sensitivity reveals common features in nucleation and elongation

  Sønderby, T. V., Rasmussen, H. Ø., Frank, S. A., Skov Pedersen, J. & Otzen, D. E., Jan 2022, In: Journal of Molecular Biology. 434, 2, 18 p., 167337.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  File

  • Nucleation 100%
  • Amyloid 100%
  • Intrinsically Disordered Protein 33%
  • Protein Folding 16%
  • Surface Area 16%
  61 Downloads (Pure)

• Functional amyloid in a lipid-like environment: a merry dance of many steps

  Otzen, D. E., Dec 2022, In: Essays in Biochemistry. 66, 7, p. 1035-1046 12 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  • Lipid 100%
  • Amyloid 100%
  • Surface Active Agent 100%
  • Surfactant 75%
  • Micelle 75%

• Functional Bacterial Amyloids: Understanding Fibrillation, Regulating Biofilm Fibril Formation and Organizing Surface Assemblies

  Sønderby, T. V., Najarzadeh, Z. & Otzen, D. E., Jul 2022, In: Molecules. 27, 13, 23 p., 4080.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

  Open Access

  • Biofilm 100%
  • Fibril 100%
  • Surface Property 100%
  • Amyloid 100%
  • Pseudomonas 66%

• Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition

  Farzadfard, A., König, A., Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F. & Otzen, D. E., May 2022, In: The Journal of Biological Chemistry. 298, 5, 14 p., 101848.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Alpha-Synuclein 100%
  • Synuclein 100%
  • Glycation 100%
  • Fibrillation Kinetics 100%
  • Ribose 30%

• How do surfactants unfold and refold proteins?

  Otzen, D. E., Pedersen, J. N., Rasmussen, H. Ø. & Pedersen, J. S., Oct 2022, In: Advances in Colloid and Interface Science. 308, 13 p., 102754.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

  Open Access

  • Surfactant 100%
  • Micelle 100%
  • X Ray 25%
  • Denaturation 25%
  • Protein 12%

• Induction, inhibition, and incorporation: Different roles for anionic and zwitterionic lysolipids in the fibrillation of the functional amyloid FapC

  Rasmussen, H. Ø., Otzen, D. E. & Pedersen, J. S., Feb 2022, In: The Journal of Biological Chemistry. 298, 2, 50 p., 101569.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • % Inhibition 100%
  • Liquefied Petroleum Gas 100%
  • Lipid 100%
  • Amyloid 100%
  • Critical Micelle Concentration 75%

• Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation.

  Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Pedersen, J. S., Nielsen, J. & Otzen, D. E., Jan 2022, In: BBA advances. 2, 100055.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Amyloid 100%
  • Membrane Vesicle 100%
  • Pseudomonas 100%
  • Biofilms 100%
  • Nucleation 100%

• Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein

  Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J.-Y. & Jensen, P. H., Mar 2022, In: Scientific Reports. 12, 3737.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Oligomerization 100%
  • Low Drug Dose 100%
  • Synuclein 100%
  • Dimethyl Sulfoxide 100%
  • Protein Catabolism 7%

• Molecular-level insights into the surface-induced assembly of Functional Bacterial Amyloid

  Sønderby, T. V., Zou, Y., Wang, P., Wang, C. & Otzen, D. E., Sept 2022, In: Biophysical Journal. 121, 18, p. 3422-3434 13 p.

  Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

  Open Access

  • Nanocrystalline Material 100%
  • Molecular Orientation 100%
  • Hybrid Material 100%
  • Molecular Structure 100%
  • Lamellar Structure 100%