Christian Bjerggaard Vægter

2023

Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer

Jensen, A. M. G., Kitago, Y., Fazeli, E., Vægter, C. B., Small, S. A., Petsko, G. A. & Andersen, O. M., Jan 2023, In: Proceedings of the National Academy of Sciences. 120, 4, 11 p., e2212180120.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain

Lautrup, S., Myrup Holst, C., Yde, A., Asmussen, S., Thinggaard, V., Larsen, K., Laursen, L. S., Richner, M., Vaegter, C. B., Prieto, G. A., Berchtold, N., Cotman, C. W. & Stevnsner, T., Sept 2023, In: Aging Cell. 22, 9, 20 p., e13905.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2022

Comparative transcriptional analysis of satellite glial cell injury response

Jager, S. E., Pallesen, L. T., Lin, L., Izzi, F., Pinheiro, A. M., Villa-Hernandez, S., Cesare, P., Vaegter, C. B. & Denk, F., May 2022, In: Wellcome Open Research. 7, 156.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Correction to: Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy

Ferreira, N., Richner, M., van der Laan, A., Jul Christiansen, I. B., Vægter, C. B., Nyengaard, J. R., Halliday, G. M., Weis, J., Giasson, B. I., Mackenzie, I. R., Jensen, P. H. & Jan, A., 2022, In: Brain Communications. 4, 2, p. fcac067 1 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

Recombinant adeno-associated virus mediated gene delivery in the extracranial nervous system of adult mice by direct nerve immersion

Richner, M., Gonçalves, N. P., Jensen, P. H., Nyengaard, J. R., Vægter, C. B. & Jan, A., Mar 2022, In: STAR Protocols. 3, 1, 15 p., 101181.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury

Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L., Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F., Glerup, S., Nykjær, A. & Vægter, C. B., May 2022, In: Frontiers in Cellular Neuroscience. 16, 15 p., 856734.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2021

Discrepancy in the Usage of GFAP as a Marker of Satellite Glial Cell Reactivity

Mohr, K. M., Pallesen, L. T., Richner, M. & Vaegter, C. B., Aug 2021, In: Biomedicines. 9, 8, 1022.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M., Mar 2021, In: Acta Neuropathologica Communications. 9, 1, 43.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy

Ferreira, N., Richner, M., van der Laan, A., Bergholdt Jul Christiansen, I., Vægter, C. B., Nyengaard, J. R., Halliday, G. M., Weiss, J., Giasson, B. I., Mackenzie, I. R., Jensen, P. H. & Jan, A., May 2021, In: Brain Communications. 3, 2, 17 p., fcab104.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses

Jan, A., Gonçalves, N. P., Vaegter, C. B., Jensen, P. H. & Ferreira, N., Aug 2021, In: International Journal of Molecular Sciences . 22, 15, 23 p., 8338.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Ferreira, N., Gonçalves, N. P., Jan, A., Jensen, N. M., van der Laan, A., Mohseni, S., Vægter, C. B. & Jensen, P. H., Feb 2021, In: Acta Neuropathologica Communications. 9, 1, 31.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Delaidelli, A., Richner, M., Jiang, L., van der Laan, A., Bergholdt Jul Christiansen, I., Ferreira, N., Nyengaard, J. R., Vægter, C. B., Jensen, P. H., Mackenzie, I. R., Sorensen, P. H. & Jan, A., Jun 2021, In: Acta Neuropathologica Communications. 9, 1, 16 p., 105.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

2020

A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T. & Bach, A. & 5 others, Strømgaard, K., Meehan, C. F., Vaegter, C. B., Gether, U. & Madsen, K. L., Apr 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., 11248.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Changes in the transcriptional fingerprint of satellite glial cells following peripheral nerve injury

Jager, S. E., Pallesen, L. T., Richner, M., Harley, P., Hore, Z., McMahon, S., Denk, F. & Vaegter, C. B., 2020, In: Glia. 68, 7, p. 1375-1395 21 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin

Gonçalves, N. P., Yan, Y., Ulrichsen, M., Venø, M. T., Poulsen, E. T., Enghild, J. J., Kjems, J. & Vægter, C. B., Oct 2020, In: Biomedicines. 8, 11, p. 1-24 24 p., 450.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Schwann cell p75 neurotrophin receptor modulates small fiber degeneration in diabetic neuropathy

Gonçalves, N. P., Jager, S. E., Richner, M., Murray, S. S., Mohseni, S., Jensen, T. S. & Vaegter, C. B., Dec 2020, In: Glia. 68, 12, p. 2725-2743 19 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

SorCS1 binds the insulin receptor to enhance insulin sensitivity

Kjolby, M., Pedersen, K. M., Breining, P., Wellner, N., Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P., Januliene, D., Manavalan, A., Rotman, M., Thotakura, G., Skeldal, S., Madsen, P., Thirup, S., Hermey, G., Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B. & Parlevliet, E. T. & 7 others, Rensen, P. C. N., Füchtbauer, E. M., Madsen, A. N., Holst, B., Andersen, O. M., Hansen, T. & Nykjaer, A., 1 Nov 2020, bioRxiv.

Research output: Working paper/Preprint › Working paper › Research

SORLA Expression in Synaptic Plexiform Layers of Mouse Retina

Monti, G., Jensen, M. L., Mehmedbasic, A., Jørgensen, M. M., Holm, I. E., Barkholt, P., Zole, E., Vægter, C. B., Vorum, H., Nyengaard, J. R. & Andersen, O. M., 2020, In: Molecular Neurobiology. 57, 7, p. 3106-3117 12 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2019

Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy

Richner, M., Ferreira, N., Dudele, A., Jensen, T. S., Vaegter, C. B. & Gonçalves, N. P., 1 Jan 2019, In: Frontiers in Neuroscience. 12, 9 p., 1038.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Open Access

Gene Transfer in Rodent Nervous Tissue Following Hindlimb Intramuscular Delivery of Recombinant Adeno-Associated Virus Serotypes AAV2/6, AAV2/8, and AAV2/9

Asad, J., Richner, M., Vægter, C. B., Nyengaard, J. R. & Jensen, P. H., Nov 2019, In: Neuroscience Insights. 14, November-December, p. 1-12

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression

Gonçalves, N. P., Mohseni, S., El Soury, M., Ulrichsen, M., Richner, M., Xiao, J., Wood, R. J., Andersen, O. M., Coulson, E. J., Raimondo, S., Murray, S. S. & Vægter, C. B., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 235.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Satellite glial cells in neuropathic pain: An RNAseq study

Jager, S. E., Denk, F., Richner, M., Pallesen, L. T., McMahon, S. B. & Vægter, C. B., Jul 2019.

Research output: Contribution to conference › Poster › Research

Schwann cell p75 neurotrophic receptor modulates phagolysosomal pathways underlying diabetes induced neurodegeneration

Goncalves, N. P., Mohseni, S., Richner, M., Murray, S. S., Staehelin-Jensen, T. & Vægter, C. B., 2019.

Research output: Contribution to conference › Poster › Research

Smertefysiologi 1: smerteanatomi og smertemekanismer

Vægter, C. B., Staehelin-Jensen, T., Arendt-Nielsen, L. & Finnerup, N. B., 2019, Smerter - baggrund, evidens og behandling. Werner, M. U., Finnerup, N. B. & Arendt-Nielsen, L. (eds.). 4 ed. København: FADL's Forlag, p. 36-51 16 p.

Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research

Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L.-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A., 19 Jun 2019, In: Science Advances. 5, 6, 13 p., eaav9946.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

The effect of Recombinant Botulinum Neurotoxin A on neuropathic pain in Spared Nerve Injury mouse model

Hammer, R. E., Richner, M., Vægter, C. B., Karlsson, P. & Nyengaard, J. R., 2019.

Research output: Contribution to conference › Poster › Research › peer-review

2018

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor

Blechingberg, J., Poulsen, A. S. A., Kjølby, M., Monti, G., Allen, M., Ivarsen, A. K., Lincoln, S. J., Thotakura, G., Vægter, C. B., Ertekin-Taner, N., Nykjær, A. & Andersen, O. M., Nov 2018, In: Neurobiology of Aging. 71, p. 266.e11-266.e24 14 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Isolation of Satellite Glial Cells for High-Quality RNA purification

Jager, S. B., Pallesen, L. T. & Vaegter, C. B., 1 Mar 2018, In: Journal of Neuroscience Methods. 297, p. 1-8 8 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Peripheral Glial Cells in the Development of Diabetic Neuropathy

Gonçalves, N. P., Vægter, C. B. & Pallesen, L. T., 2 May 2018, In: Frontiers in Neurology. 9, 9 p., 268.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Schwann cell p75 neurotrophic receptor and type 2 diabetic neuropathy

Goncalves, N. P., Richner, M., Murray, S. S., Staehelin-Jensen, T. & Vægter, C. B., 2018.

Research output: Contribution to conference › Poster › Research

Schwann cell p75 neurotrophic receptor controls phagosome and lysosome pathways important for diabetes-induced neurodegeneration

Goncalves, N. P., Nabben, D., Richner, M., Mohseni, S., Murray, S. S., Staehelin-Jensen, T. & Vægter, C. B., 2018.

Research output: Contribution to conference › Poster › Research

2017

Glucocorticoids - Efficient analgesics against postherpetic neuralgia?

Richner, M. & Vaegter, C. B., Jul 2017, In: Scandinavian Journal of Pain. 16, p. 61-63 3 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Hydraulic extrusion of the spinal cord and isolation of the dorsal root ganglia in rodents

Richner, M., Jager, S. B., Siupka, P. & Vægter, C. B., 22 Jan 2017, In: Journal of Visualized Experiments. 2017, 119, e55226.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Open Access

Schwann cell interactions with axons and microvessels in diabetic neuropathy

Gonçalves, N. P., Vægter, C. B., Andersen, H., Østergaard, L., Calcutt, N. A. & Jensen, T. S., 30 Mar 2017, In: Nature Reviews. Neurology. 13, 3, p. 135-147 13 p.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Sortilin in microglia reactivity

Svenningsen, A. L. S., Jager, S. B., Richner, M., Dieu, R., Pallesen, L. T. & Vægter, C. B., 27 Jan 2017.

Research output: Contribution to conference › Conference abstract for conference › Research

The Forgotten Cell Type in Neuropathic Pain

Jager, S. E., Denk, F., Richner, M., Goncalves, N. P., Pallesen, L. T., McMahon, S. B. & Vægter, C. B., 2017.

Research output: Contribution to conference › Poster › Research

2016

Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover

Larsen, J. V., Kristensen, A. M., Pallesen, L. T., Bauer, J., Vægter, C. B., Nielsen, M. S., Madsen, P. & Petersen, C. M., 2016, In: Molecular and Cellular Biology.

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Open Access

Christian Bjerggaard Vægter

Research output

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