Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
Final published version
In this chapter, we develop a model of μ- and δ-opioid receptor (OR) effects on cellular activity in the corticostriatal circuit after reviewing clinical data on cognitive and mood impairments in opioid substance use disorder (OUD), we use this model to derive information on the relevance of opioid actions in this circuit for cognition and reward. We find that the cognitive impairments and rewarding properties of acute μ-OR activation can reasonably explained by pharmacological actions in the corticostriatal circuit. However, long-term cognitive impairments and mood dysfunction observed in OUD are probably induced by opiate abuse-related degenerative mechanisms.
| Original language | English |
|---|---|
| Title of host publication | The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems |
| Editors | Shane O'Mara |
| Number of pages | 49 |
| Volume | 239 |
| Publisher | Elsevier |
| Publication year | 2018 |
| Pages | 179-227 |
| Chapter | 5 |
| ISBN (print) | 9780444641670 |
| DOIs | |
| Publication status | Published - 2018 |
| Series | Progress in Brain Research |
|---|---|
| Volume | 239 |
| ISSN | 0079-6123 |
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ID: 150102470