Connie Sánchez

  1. Journal article › Research › Peer-reviewed
  2. Published

    A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment. / Chen, Fenghua; Danladi, Jibrin; Ardalan, Maryam; Elfving, Betina; Müller, Heidi K; Wegener, Gregers; Sanchez, Connie; Nyengaard, Jens R.

    In: International Journal of Neuropsychopharmacology, Vol. 21, No. 6, 2018, p. 603-615.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. Published

    A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex. / du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup; Sanchez, Connie; Wegener, Gregers; Elfving, Betina.

    In: European Journal of Pharmacology, Vol. 786, 25.05.2016, p. 29-35.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation. / Etiévant, A; Oosterhof, C; Bétry, C; Abrial, E; Novo-Perez, M; Rovera, R; Scarna, H; Devader, C; Mazella, J; Wegener, G; Sánchez, C; Dkhissi-Benyahya, O; Gronfier, C; Coizet, V; Beaulieu, J M; Blier, P; Lucas, G; Haddjeri, N.

    In: EBioMedicine, Vol. 2, No. 8, 08.2015, p. 896-906.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. / Hatherall, Lauren; Sanchez, Connie; Morilak, David A.

    In: International Journal of Neuropsychopharmacology, Vol. 20, No. 4, 01.04.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Df(h15q13)/+ Mouse Model Reveals Loss of Astrocytes and Synaptic-Related Changes of the Excitatory and Inhibitory Circuits in the Medial Prefrontal Cortex. / Al-Absi, Abdel-Rahman; Qvist, Per; Glerup, Simon; Sanchez, Connie; Nyengaard, Jens R.

    In: Cerebral Cortex, Vol. 31, No. 3, 03.2021, p. 1609-1621.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression. / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Elfving, Betina; Sanchez, Connie; Wegener, Gregers.

    In: Psychopharmacology, Vol. 233, No. 14, 07.2016, p. 2813-2825.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior. / Eskelund, Amanda; Li, Yan; Budac, David P.; Müller, Heidi K.; Gulinello, Maria; Sanchez, Connie; Wegener, Gregers.

    In: Journal of Neurochemistry, Vol. 142, No. 1, 01.07.2017, p. 118-131.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Evaluation of semi-automatic 3D reconstruction for studying geometry of dendritic spines. / Al-Absi, Abdel Rahman; Christensen, Heidi Søgaard; Sanchez, Connie; Nyengaard, Jens Randel.

    In: Journal of Chemical Neuroanatomy, Vol. 94, 01.12.2018, p. 119-124.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism. / Eskelund, Amanda; Budac, David P; Sanchez, Connie; Elfving, Betina; Wegener, Gregers.

    In: Neuroscience, Vol. 329, 19.05.2016, p. 337-348.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the Flinders Sensitive Line rat model of depression : Effect of ketamine. / du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup; Sanchez, Connie; Wegener, Gregers; Elfving, Betina.

    In: Synapse, Vol. 71, No. 1, 01.2017, p. 37–45.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits : Comparisons with Escitalopram. / Chakroborty, Shreaya; Geisbush, Thomas R.; Dale, Elena; Pehrson, Alan L.; Sanchez, Connie; West, Anthony R.

    In: Frontiers in Pharmacology, Vol. 8, 764, 26.10.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability. / Al-Absi, Abdel-Rahman; Qvist, Per; Okujeni, Samora; Khan, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Nyengaard, Jens R.

    In: Molecular Neurobiology, Vol. 57, No. 12, 12.2020, p. 4978–4988 .

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents. / Waller, Jessica A; Nygaard, Sara Holm; Li, Yan; du Jardin, Kristian Gaarn; Tamm, Joseph A; Abdourahman, Aicha; Elfving, Betina; Pehrson, Alan L; Sánchez, Connie; Wernersson, Rasmus.

    In: B M C Neuroscience, Vol. 18, No. 1, 04.08.2017, p. 56.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Opioid system modulation of cognitive affective bias implications for the treatment of mood disorders. / Varastehmoradi, Bardia; Wegener, Gregers; Sanchez, Connie; Smith, Karen L.

    In: Behavioural Pharmacology, Vol. 31, No. 2&3, 04.2020, p. 122-135.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. / Smith, Karen L.; Cunningham, Jacobi I.; Eyerman, David J.; Dean, Reginald L.; Deaver, Daniel R.; Sanchez, Connie.

    In: Neuropharmacology, Vol. 146, No. March, 2019, p. 316-326.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Potential involvement of serotonergic signaling in ketamine's antidepressant actions : A critical review. / du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup; Elfving, Betina; Dale, Elena; Wegener, Gregers; Sanchez, Connie.

    In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol. 71, 03.11.2016, p. 27-38.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression. / du Jardin, Kristian G; Liebenberg, Nico; Cajina, Manuel; Müller, Heidi K; Elfving, Betina; Sanchez, Connie; Wegener, Gregers.

    In: Frontiers in Pharmacology, Vol. 8, 2017, p. 978.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression. / Sanchez, Connie; El Khoury, Aram; Hassan, Moustapha; Wegener, Gregers; Mathe, Aleksander A.

    In: Behavioural Brain Research, Vol. 351, 2018, p. 93-103.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats. / Riga, Maurizio S.; Sanchez, Connie; Celada, Pau; Artigas, Francesc.

    In: Neuropharmacology, Vol. 178, 108238, 11.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT 3 receptor expressing interneurons : An in vitro study in rat hippocampus slices. / Dale, Elena; Grunnet, Morten; Pehrson, Alan L.; Frederiksen, Kristen; Larsen, Peter H.; Nielsen, Jacob; Stensbøl, Tine B.; Ebert, Bjarke; Yin, Haolan; Lu, Dunguo; Liu, Huiquing; Jensen, Thomas N.; Yang, Charles R.; Sanchez, Connie.

    In: Brain Research, Vol. 1689, 15.06.2018, p. 1-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. / Chen, Fenghua; Danladi, Jibrin; Ardalan, Maryam; Nyengaard, Jens Randel; Sánchez, Connie; Wegener, Gregers.

    In: European Neuropsychopharmacology, Vol. 42, 01.2021, p. 45-56.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Vortioxetine Reduces Marble Burying but Only Transiently Enhances Social Interaction Preference in Adult Male BTBR T+Itpr3tf/J Mice. / Witt, Nasriya A.; Lee, Benita; Ghent, Kaylee; Zhang, Wynne Q.; Pehrson, Alan L.; Sánchez, Connie; Gould, Georgianna G.

    In: ACS Chemical Neuroscience, Vol. 10, No. 10, 10.2019, p. 4319-4327.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Vortioxetine differentially modulates MK-801-induced changes in visual signal detection task performance and locomotor activity. / Hillhouse, Todd M.; Merritt, Christina R.; Smith, Douglas A.; Cajina, Manuel; Sanchez, Connie; Porter, Joseph H.; Pehrson, Alan L.

    In: Frontiers in Pharmacology, Vol. 9, No. SEP, 1024, 13.09.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Vortioxetine improves context discrimination in mice through a neurogenesis independent mechanism. / Felice, Daniela; Guilloux, Jean Philippe; Pehrson, Alan; Li, Yan; Mendez-David, Indira; Gardier, Alain M.; Sanchez, Connie; David, Denis J.

    In: Frontiers in Pharmacology, Vol. 9, No. MAR, 204, 12.03.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. / Chen, Fenghua; du Jardin, Kristian Gaarn; Waller, Jessica A; Sanchez, Connie; Nyengaard, Jens R; Wegener, Gregers.

    In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 26, No. 2, 02.2016, p. 234-245.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Vortioxetine treatment reverses subchronic PCP treatment-induced cognitive impairments : A potential role for serotonin receptor-mediated regulation of GABA neurotransmission. / Pehrson, Alan L.; Pedersen, Christian S.; Tølbøl, Kirstine Sloth; Sanchez, Connie.

    In: Frontiers in Pharmacology, Vol. 9, No. MAR, 162, 06.03.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    X-ray structure based evaluation of analogs of citalopram : Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT. / Topiol, Sid; Bang-Andersen, Benny; Sanchez, Connie; Plenge, Per; Loland, Claus J.; Juhl, Karsten; Larsen, Krestian; Bregnedal, Peter; Bogeso, Klaus P.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 27, No. 3, 01.02.2017, p. 470-478.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Review › Research › Peer-reviewed
  30. Published

    Opioid receptor modulation of neural circuits in depression : What can be learned from preclinical data? / Puryear, Corey B.; Brooks, Julie; Tan, Laura; Smith, Karen; Li, Yan; Cunningham, Jacobi; Todtenkopf, Mark S.; Dean, Reginald L.; Sanchez, Connie.

    In: Neuroscience and Biobehavioral Reviews, Vol. 108, 01.2020, p. 658-678.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  31. Conference abstract in journal › Research › Peer-reviewed
  32. Published

    A serotonin-dependent mechanism is essential for the sustained antidepressant-like effect of ketamine in a rat model of depression. / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Sánchez, Connie; Wegener, Gregers.

    In: Acta Neuropsychiatrica, Vol. 26, No. S1, 2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  33. Published

    Differentiated antidepressant-like profiles of ketamine, fluoxetine and vortioxetine in Flinders Sensitive Line rats depleted of endogenous 5-HT. / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Elfving, Betina; Sánchez, Connie; Wegener, Gregers.

    In: Acta Neuropsychiatrica, Vol. 27, No. S1, 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  34. Published

    Endogenous 5-HT receptor stimulation is critical for the antidepressant-like effect of ketamine but not vortioxetine. / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Elfving, Betina; Sánchez, Connie; Wegener, Gregers.

    In: Acta Neuropsychiatrica, Vol. 28, No. S2, 2016, p. 19-20.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  35. Published

    P. 2. e. 001 Differentiated antidepressant-like profiles of ketamine, fluoxetine and vortioxetine in Flinders Sensitive Line (FSL) rats depleted of endogenous 5-HT. / Du Jardin, K. G.; Liebenberg, N.; Müller, Heidi Kaastrup; Elfving, B.; Wegener, G.; Sanchez, C.

    In: European Neuropsychopharmacology, Vol. 25, 09.2015, p. S431-S431.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  36. Published

    Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct serotonin receptor modulation. / du Jardin, Kristian Gaarn; Jensen, Jesper B.; Song, Dekun; Budac, David; Sánchez, Connie; Pehrson, Alan L.

    In: Acta Neuropsychiatrica, Vol. 25, No. S1, 2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearchpeer-review

  37. Book chapter › Research › Peer-reviewed
  38. Published

    Frontal cortex dysfunction as a target for remediation in opiate use disorder : Role in cognitive dysfunction and disordered reward systems. / Roberts, Dominic; Wolfarth, Andrew; Sanchez, Connie; Pehrson, Alan L.

    The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems. ed. / Shane O'Mara. Vol. 239 Elsevier, 2018. p. 179-227 (Progress in Brain Research, Vol. 239).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  39. Poster › Research › Peer-reviewed
  40. Published

    A serotonin-dependent mechanism is essential for the protracted antidepressant-like effect of ketamine in a rat model of depression. / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Elfving, Betina; Sánchez, Connie; Wegener, Gregers.

    2014. Poster session presented at Society for Neuroscience 2014, Washington DC, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  41. Published

    A single dose of vortioxetine or ketamine, but not fluoxetine, increases transcript levels of genes involved in neuroplasticity in the rat prefrontal cortex. / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Sánchez, Connie; Wegener, Gregers; Elfving, Betina.

    2013. Poster session presented at Neuroscience 2013 - SFN annual meeting, San Diego, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  42. Published

    P90. Differentiated antidepressantlike profiles of ketamine, fluoxetine and vortioxetine in Flinders Sensitive Line rats depleted of endogenous 5-HT—An approach to gain new mechanistic insights? / du Jardin, Kristian Gaarn; Liebenberg, Nico; Müller, Heidi Kaastrup; Wegener, Gregers; Sánchez, Connie; Elfving, Betina.

    2015. Poster session presented at 48th Annual Winter Conference on Brain Research, Big Sky, MO, United States.

    Research output: Contribution to conferencePosterResearchpeer-review