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Claus Oxvig

Pregnancy-associated plasma protein-A expression in human breast cancer

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  • Aaron S Mansfield, Division of Medical Oncology, Department of Laboratory Medicine, Rocherster, United States
  • Daniel W Visscher, Division of Medical Oncology, Department of Pathology, Rochester, United States
  • Steven N Hart, Division of Medical Oncology, Department of Health Sciences Research, Rochester, United States
  • Chen Wang, Division of Medical Oncology, Department of Health Sciences Research, Rochester, United States
  • Matthew P Goetz, Division of Medical Oncology, Department of Laboratory Medicine, Rocherster, United States
  • Claus Oxvig
  • Cheryl A Conover, Division of Medical Oncology, Department of Health Sciences Research, Rochester, United States

OBJECTIVE: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer. Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2+, HER2+, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry.

RESULTS: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (P=0.01). However, there were no differences between specimens positive or negative for HER2 (P=0.14) or positive and negative for estrogen receptor (P=0.31).

CONCLUSION: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.

Original languageEnglish
JournalGrowth Hormone & I G F Research
Volume24
Issue6
Pages (from-to)264-267
Number of pages4
ISSN1096-6374
DOIs
Publication statusPublished - 31 Oct 2014

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