Claus Oxvig

Porcine synapsin 1: SYN1 gene analysis and functional characterization of the promoter

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Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means of expressing a transgene specifically in neurons. The nucleotide sequence of the promoter displayed a high degree of conservation of elements responsible for neuron-specific expression. Expression analysis of SYN1 demonstrated presence of transcript during embryonic development. Analysis of GFP expression in transgenic zebrafish embryos suggests that the pig SYN1 promoter directs expression in neuronal cells. Thus, the SYN1 promoter is a good candidate for use in the generation of pig models of human neurodegenerative disorders
Original languageEnglish
JournalF E B S Open Bio
Volume3
Pages (from-to)411–420
Number of pages10
ISSN2211-5463
DOIs
Publication statusPublished - 2013

    Research areas

  • GFP, Neuron-specific promoter, Pig, Transgenic, Zebrafish

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