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Claus Oxvig

Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein

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Eosinophil granule major basic protein (117 residues) is known to contain free sulfhydryl groups. Here we have located in the amino acid sequence the half-cystine residues present as cysteine, and identified those engaged in disulfide bridges. Of the 9 half-cystine residues, 5 are unpaired cysteines (Cys2, Cys23, Cys42, Cys64, and Cys96), while 4 form disulfides (Cys20-Cys115, and Cys92-Cys107).
Original languageEnglish
JournalFEBS Letters
Volume341
Issue2-3
Pages (from-to)213-217
Number of pages5
ISSN0014-5793
Publication statusPublished - 21 Mar 1994

    Research areas

  • Amino Acid Sequence, Blood Proteins, Chromatography, High Pressure Liquid, Cysteine, Cystine, Disulfides, Eosinophil Granule Proteins, Humans, Molecular Sequence Data, Peptide Mapping, Ribonucleases, Sulfhydryl Compounds

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