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Claus Oxvig

Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome

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  • Qui-Ping Qin, Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark. qiqin@utu.fi, Denmark
  • Michael Christiansen, Departments of Clinical Biochemistry and Immunology, Statens Seruminstitut, , Denmark
  • Claus Oxvig
  • Kim Pettersson, Department of Biotechnology, University of Turku, Finland
  • Lars Sottrup-Jensen
  • Claus Koch, Departments of Clinical Biochemistry and Immunology, Statens Seruminstitutd, Denmark
  • Bent Nørgaard-Pedersen, Departments of Clinical Biochemistry and Immunology, Statens Seruminstitut, Denmark
Four double-monoclonal time-resolved immunofluorometric assays (TrIFMAs) have been developed for the specific determination of pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/ proMBP) complex in first-trimester maternal serum samples. The assays have a functional sensitivity of
Original languageEnglish
JournalClinical Chemistry
Volume43
Issue12
Pages (from-to)2323-2332
Number of pages10
ISSN0009-9147
Publication statusPublished - Dec 1997

    Research areas

  • Antibodies, Monoclonal, Biological Markers, Blood Proteins, Chromatography, Gel, Down Syndrome, Eosinophil Major Basic Protein, Female, Fluoroimmunoassay, Humans, Pregnancy, Pregnancy Trimester, First, Pregnancy-Associated Plasma Protein-A, Prenatal Diagnosis, Proteoglycans, Reproducibility of Results, Sensitivity and Specificity

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