Aarhus University Seal / Aarhus Universitets segl

Claus Oxvig

40 years of IGF1: PAPP-A and cancer

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Standard

40 years of IGF1 : PAPP-A and cancer. / Conover, Cheryl A.; Oxvig, Claus.

In: Journal of Molecular Endocrinology, Vol. 61, No. 1, 01.07.2018, p. T1-T10.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Conover, CA & Oxvig, C 2018, '40 years of IGF1: PAPP-A and cancer', Journal of Molecular Endocrinology, vol. 61, no. 1, pp. T1-T10. https://doi.org/10.1530/JME-17-0236

APA

Conover, C. A., & Oxvig, C. (2018). 40 years of IGF1: PAPP-A and cancer. Journal of Molecular Endocrinology, 61(1), T1-T10. https://doi.org/10.1530/JME-17-0236

CBE

Conover CA, Oxvig C. 2018. 40 years of IGF1: PAPP-A and cancer. Journal of Molecular Endocrinology. 61(1):T1-T10. https://doi.org/10.1530/JME-17-0236

MLA

Conover, Cheryl A. and Claus Oxvig. "40 years of IGF1: PAPP-A and cancer". Journal of Molecular Endocrinology. 2018, 61(1). T1-T10. https://doi.org/10.1530/JME-17-0236

Vancouver

Conover CA, Oxvig C. 40 years of IGF1: PAPP-A and cancer. Journal of Molecular Endocrinology. 2018 Jul 1;61(1):T1-T10. https://doi.org/10.1530/JME-17-0236

Author

Conover, Cheryl A. ; Oxvig, Claus. / 40 years of IGF1 : PAPP-A and cancer. In: Journal of Molecular Endocrinology. 2018 ; Vol. 61, No. 1. pp. T1-T10.

Bibtex

@article{345ff0ca4fa14af8a6c3334173969e38,
title = "40 years of IGF1: PAPP-A and cancer",
abstract = "The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.",
keywords = "Breast cancer, Ewing sarcoma, Insulin-like growth factor, Lung cancer, Melanoma, Mesothelioma, Ovarian cancer, Pregnancy-associated plasma protein-A, Stanniocalcin",
author = "Conover, {Cheryl A.} and Claus Oxvig",
year = "2018",
month = jul,
day = "1",
doi = "10.1530/JME-17-0236",
language = "English",
volume = "61",
pages = "T1--T10",
journal = "Journal of Molecular Endocrinology",
issn = "0952-5041",
publisher = "BioScientifica Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - 40 years of IGF1

T2 - PAPP-A and cancer

AU - Conover, Cheryl A.

AU - Oxvig, Claus

PY - 2018/7/1

Y1 - 2018/7/1

N2 - The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

AB - The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

KW - Breast cancer

KW - Ewing sarcoma

KW - Insulin-like growth factor

KW - Lung cancer

KW - Melanoma

KW - Mesothelioma

KW - Ovarian cancer

KW - Pregnancy-associated plasma protein-A

KW - Stanniocalcin

UR - http://www.scopus.com/inward/record.url?scp=85051057969&partnerID=8YFLogxK

U2 - 10.1530/JME-17-0236

DO - 10.1530/JME-17-0236

M3 - Review

C2 - 29844094

AN - SCOPUS:85051057969

VL - 61

SP - T1-T10

JO - Journal of Molecular Endocrinology

JF - Journal of Molecular Endocrinology

SN - 0952-5041

IS - 1

ER -